Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140407525> ?p ?o ?g. }
- W2140407525 endingPage "173" @default.
- W2140407525 startingPage "165" @default.
- W2140407525 abstract "Background: Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk. Objective: Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings. Methods: Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls. Results: CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58–0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent. Conclusions: CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk." @default.
- W2140407525 created "2016-06-24" @default.
- W2140407525 creator A5013313171 @default.
- W2140407525 creator A5015275115 @default.
- W2140407525 creator A5050988193 @default.
- W2140407525 creator A5053300118 @default.
- W2140407525 creator A5055221957 @default.
- W2140407525 creator A5059607429 @default.
- W2140407525 creator A5070458733 @default.
- W2140407525 creator A5071141746 @default.
- W2140407525 creator A5084604658 @default.
- W2140407525 date "2013-09-02" @default.
- W2140407525 modified "2023-10-14" @default.
- W2140407525 title "Cytomegalovirus seropositivity is negatively associated with multiple sclerosis" @default.
- W2140407525 cites W1759136321 @default.
- W2140407525 cites W1774347236 @default.
- W2140407525 cites W1965679983 @default.
- W2140407525 cites W1968555340 @default.
- W2140407525 cites W1970849805 @default.
- W2140407525 cites W1980263659 @default.
- W2140407525 cites W1984168657 @default.
- W2140407525 cites W1993741037 @default.
- W2140407525 cites W1995352677 @default.
- W2140407525 cites W2019009797 @default.
- W2140407525 cites W2019329212 @default.
- W2140407525 cites W2028184978 @default.
- W2140407525 cites W2078229430 @default.
- W2140407525 cites W2083296472 @default.
- W2140407525 cites W2087053079 @default.
- W2140407525 cites W2091726860 @default.
- W2140407525 cites W2095200251 @default.
- W2140407525 cites W2095267977 @default.
- W2140407525 cites W2115880208 @default.
- W2140407525 cites W2120659687 @default.
- W2140407525 cites W2124413251 @default.
- W2140407525 cites W2126746487 @default.
- W2140407525 cites W2130116938 @default.
- W2140407525 cites W2134290014 @default.
- W2140407525 cites W2141693247 @default.
- W2140407525 cites W2145992817 @default.
- W2140407525 cites W2161245845 @default.
- W2140407525 cites W2163521262 @default.
- W2140407525 cites W2163782912 @default.
- W2140407525 cites W2172294899 @default.
- W2140407525 cites W2521975063 @default.
- W2140407525 cites W2916040650 @default.
- W2140407525 cites W4376595335 @default.
- W2140407525 cites W3144236256 @default.
- W2140407525 doi "https://doi.org/10.1177/1352458513494489" @default.
- W2140407525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23999606" @default.
- W2140407525 hasPublicationYear "2013" @default.
- W2140407525 type Work @default.
- W2140407525 sameAs 2140407525 @default.
- W2140407525 citedByCount "87" @default.
- W2140407525 countsByYear W21404075252014 @default.
- W2140407525 countsByYear W21404075252015 @default.
- W2140407525 countsByYear W21404075252016 @default.
- W2140407525 countsByYear W21404075252017 @default.
- W2140407525 countsByYear W21404075252018 @default.
- W2140407525 countsByYear W21404075252019 @default.
- W2140407525 countsByYear W21404075252020 @default.
- W2140407525 countsByYear W21404075252021 @default.
- W2140407525 countsByYear W21404075252022 @default.
- W2140407525 countsByYear W21404075252023 @default.
- W2140407525 crossrefType "journal-article" @default.
- W2140407525 hasAuthorship W2140407525A5013313171 @default.
- W2140407525 hasAuthorship W2140407525A5015275115 @default.
- W2140407525 hasAuthorship W2140407525A5050988193 @default.
- W2140407525 hasAuthorship W2140407525A5053300118 @default.
- W2140407525 hasAuthorship W2140407525A5055221957 @default.
- W2140407525 hasAuthorship W2140407525A5059607429 @default.
- W2140407525 hasAuthorship W2140407525A5070458733 @default.
- W2140407525 hasAuthorship W2140407525A5071141746 @default.
- W2140407525 hasAuthorship W2140407525A5084604658 @default.
- W2140407525 hasConcept C104317684 @default.
- W2140407525 hasConcept C107130276 @default.
- W2140407525 hasConcept C126322002 @default.
- W2140407525 hasConcept C135763542 @default.
- W2140407525 hasConcept C146304588 @default.
- W2140407525 hasConcept C147483822 @default.
- W2140407525 hasConcept C159654299 @default.
- W2140407525 hasConcept C188280979 @default.
- W2140407525 hasConcept C203014093 @default.
- W2140407525 hasConcept C205545832 @default.
- W2140407525 hasConcept C2522874641 @default.
- W2140407525 hasConcept C2776409557 @default.
- W2140407525 hasConcept C2777732132 @default.
- W2140407525 hasConcept C2780640218 @default.
- W2140407525 hasConcept C2780727368 @default.
- W2140407525 hasConcept C2908647359 @default.
- W2140407525 hasConcept C31467283 @default.
- W2140407525 hasConcept C32611913 @default.
- W2140407525 hasConcept C55493867 @default.
- W2140407525 hasConcept C71924100 @default.
- W2140407525 hasConcept C86803240 @default.
- W2140407525 hasConcept C99454951 @default.
- W2140407525 hasConceptScore W2140407525C104317684 @default.
- W2140407525 hasConceptScore W2140407525C107130276 @default.