Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140422012> ?p ?o ?g. }
- W2140422012 endingPage "a011353" @default.
- W2140422012 startingPage "a011353" @default.
- W2140422012 abstract "Upon entering a presynaptic terminal, an action potential opens Ca(2+) channels, and transiently increases the local Ca(2+) concentration at the presynaptic active zone. Ca(2+) then triggers neurotransmitter release within a few hundred microseconds by activating synaptotagmins Ca(2+). Synaptotagmins bind Ca(2+) via two C2-domains, and transduce the Ca(2+) signal into a nanomechanical activation of the membrane fusion machinery; this activation is mediated by the Ca(2+)-dependent interaction of the synaptotagmin C2-domains with phospholipids and SNARE proteins. In triggering exocytosis, synaptotagmins do not act alone, but require an obligatory cofactor called complexin, a small protein that binds to SNARE complexes and simultaneously activates and clamps the SNARE complexes, thereby positioning the SNARE complexes for subsequent synaptotagmin action. The conserved function of synaptotagmins and complexins operates generally in most, if not all, Ca(2+)-regulated forms of exocytosis throughout the body in addition to synaptic vesicle exocytosis, including in the degranulation of mast cells, acrosome exocytosis in sperm cells, hormone secretion from endocrine cells, and neuropeptide release." @default.
- W2140422012 created "2016-06-24" @default.
- W2140422012 creator A5061921730 @default.
- W2140422012 date "2011-11-08" @default.
- W2140422012 modified "2023-10-14" @default.
- W2140422012 title "Calcium Control of Neurotransmitter Release" @default.
- W2140422012 cites W1534752637 @default.
- W2140422012 cites W1591133722 @default.
- W2140422012 cites W1644847400 @default.
- W2140422012 cites W1907518241 @default.
- W2140422012 cites W1963883410 @default.
- W2140422012 cites W1966803885 @default.
- W2140422012 cites W1967817609 @default.
- W2140422012 cites W1969421890 @default.
- W2140422012 cites W1970930136 @default.
- W2140422012 cites W1976283234 @default.
- W2140422012 cites W1976479871 @default.
- W2140422012 cites W1980682773 @default.
- W2140422012 cites W1992163176 @default.
- W2140422012 cites W1998265268 @default.
- W2140422012 cites W1999702498 @default.
- W2140422012 cites W2000817025 @default.
- W2140422012 cites W2003674836 @default.
- W2140422012 cites W2008146383 @default.
- W2140422012 cites W2008456025 @default.
- W2140422012 cites W2009024468 @default.
- W2140422012 cites W2009639277 @default.
- W2140422012 cites W2016698582 @default.
- W2140422012 cites W2018757497 @default.
- W2140422012 cites W2019766891 @default.
- W2140422012 cites W2027399226 @default.
- W2140422012 cites W2031779883 @default.
- W2140422012 cites W2032840486 @default.
- W2140422012 cites W2037168572 @default.
- W2140422012 cites W2041423137 @default.
- W2140422012 cites W2041513765 @default.
- W2140422012 cites W2042055643 @default.
- W2140422012 cites W2044347304 @default.
- W2140422012 cites W2044679183 @default.
- W2140422012 cites W2050427247 @default.
- W2140422012 cites W2053635222 @default.
- W2140422012 cites W2054800842 @default.
- W2140422012 cites W2056293200 @default.
- W2140422012 cites W2058022492 @default.
- W2140422012 cites W2058035029 @default.
- W2140422012 cites W2065359945 @default.
- W2140422012 cites W2071678827 @default.
- W2140422012 cites W2073850595 @default.
- W2140422012 cites W2075174600 @default.
- W2140422012 cites W2076311985 @default.
- W2140422012 cites W2078686355 @default.
- W2140422012 cites W2079061153 @default.
- W2140422012 cites W2084030140 @default.
- W2140422012 cites W2085537082 @default.
- W2140422012 cites W2086036400 @default.
- W2140422012 cites W2094337062 @default.
- W2140422012 cites W2102492718 @default.
- W2140422012 cites W2103194330 @default.
- W2140422012 cites W2106758010 @default.
- W2140422012 cites W2110533122 @default.
- W2140422012 cites W2111301445 @default.
- W2140422012 cites W2121235255 @default.
- W2140422012 cites W2123355036 @default.
- W2140422012 cites W2126548245 @default.
- W2140422012 cites W2136422440 @default.
- W2140422012 cites W2139420483 @default.
- W2140422012 cites W2140739793 @default.
- W2140422012 cites W2140927249 @default.
- W2140422012 cites W2143830427 @default.
- W2140422012 cites W2150487147 @default.
- W2140422012 cites W2150670276 @default.
- W2140422012 cites W2154100802 @default.
- W2140422012 cites W2165302477 @default.
- W2140422012 cites W2168315683 @default.
- W2140422012 cites W2171279562 @default.
- W2140422012 cites W2693779834 @default.
- W2140422012 doi "https://doi.org/10.1101/cshperspect.a011353" @default.
- W2140422012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3249630" @default.
- W2140422012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22068972" @default.
- W2140422012 hasPublicationYear "2011" @default.
- W2140422012 type Work @default.
- W2140422012 sameAs 2140422012 @default.
- W2140422012 citedByCount "335" @default.
- W2140422012 countsByYear W21404220122012 @default.
- W2140422012 countsByYear W21404220122013 @default.
- W2140422012 countsByYear W21404220122014 @default.
- W2140422012 countsByYear W21404220122015 @default.
- W2140422012 countsByYear W21404220122016 @default.
- W2140422012 countsByYear W21404220122017 @default.
- W2140422012 countsByYear W21404220122018 @default.
- W2140422012 countsByYear W21404220122019 @default.
- W2140422012 countsByYear W21404220122020 @default.
- W2140422012 countsByYear W21404220122021 @default.
- W2140422012 countsByYear W21404220122022 @default.
- W2140422012 countsByYear W21404220122023 @default.
- W2140422012 crossrefType "journal-article" @default.
- W2140422012 hasAuthorship W2140422012A5061921730 @default.
- W2140422012 hasBestOaLocation W21404220121 @default.