FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140448575> ?p ?o ?g. }

• W2140448575 abstract "We explored the heterogeneity of philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL) in a study of the effect of early features on prognosis in children. Here we report the long-term results of the FRALLE 93 study conducted in the era before the use of tyrosine kinase inhibitors. Between 1993 and 1999, 36 children with Ph1-ALL were enrolled into the FRALLE 93 protocol. After conventional four-drug induction, children were stratified by availability of an HLA-matched sibling. Complete remission (CR) was observed in 26 children (72%), of which 13 underwent allogeneic bone marrow transplantation (BMT). Thirty-one children were good responders to prednisone, defined on day 8, and 21 were good responders to chemotherapy, defined by day-21 bone marrow (M1). Overall five-year disease-free survival (DFS) was 42 ± 9.7%. Based on multivariate analysis, two groups showed marked differences in five-year outcome: children with age<10, leukocyte count <100,000/mm3 and day-21 M1 marrow had a more favorable prognosis (14 pts: 100% CR, event free survival [EFS]: 57%, overall survival [OS]: 79%), than the high-risk group (22 patients: 55% CR, EFS: 18%, OS: 27%) (p < 0.005). We also observed a non statistically significant difference (p = 0.14) in outcome between these groups for transplanted patients (5-year DFS: 83 ± 14% and 33 ± 15%, respectively). Age, leukocyte count and early response to treatment defined by the D21 bone marrow response provide an accurate model for outcome prediction. The combination of available tools such as minimal residual disease assessment with determination of these simple factors could be useful for refining indications for BMT in the current era of tyrosine-kinase inhibitor-based therapy." @default.
• W2140448575 created "2016-06-24" @default.
• W2140448575 creator A5010201728 @default.
• W2140448575 creator A5012805294 @default.
• W2140448575 creator A5018536511 @default.
• W2140448575 creator A5023552802 @default.
• W2140448575 creator A5032184750 @default.
• W2140448575 creator A5032410204 @default.
• W2140448575 creator A5032886139 @default.
• W2140448575 creator A5037694078 @default.
• W2140448575 creator A5040756049 @default.
• W2140448575 creator A5050203564 @default.
• W2140448575 creator A5052673276 @default.
• W2140448575 creator A5054047613 @default.
• W2140448575 creator A5062989284 @default.
• W2140448575 creator A5067679686 @default.
• W2140448575 creator A5073306699 @default.
• W2140448575 creator A5077369264 @default.
• W2140448575 date "2009-01-13" @default.
• W2140448575 modified "2023-10-18" @default.
• W2140448575 title "Impact of age, leukocyte count and day 21-bone marrow response to chemotherapy on the long-term outcome of children with philadelphia chromosome-positive acute lymphoblastic leukemia in the pre-imatinib era: results of the FRALLE 93 study" @default.
• W2140448575 cites W1984877560 @default.
• W2140448575 cites W1987891242 @default.
• W2140448575 cites W1998870431 @default.
• W2140448575 cites W2000116184 @default.
• W2140448575 cites W2002433192 @default.
• W2140448575 cites W2016763091 @default.
• W2140448575 cites W2028104399 @default.
• W2140448575 cites W2080007107 @default.
• W2140448575 cites W2092925278 @default.
• W2140448575 cites W2099616647 @default.
• W2140448575 cites W2114358266 @default.
• W2140448575 cites W2125178103 @default.
• W2140448575 cites W2130160254 @default.
• W2140448575 cites W2138591172 @default.
• W2140448575 cites W2140946267 @default.
• W2140448575 cites W2147996630 @default.
• W2140448575 cites W2148854558 @default.
• W2140448575 cites W2156191281 @default.
• W2140448575 cites W2163878076 @default.
• W2140448575 cites W59733412 @default.
• W2140448575 cites W80054229 @default.
• W2140448575 doi "https://doi.org/10.1186/1471-2407-9-14" @default.
• W2140448575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2629767" @default.
• W2140448575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19144139" @default.
• W2140448575 hasPublicationYear "2009" @default.
• W2140448575 type Work @default.
• W2140448575 sameAs 2140448575 @default.
• W2140448575 citedByCount "12" @default.
• W2140448575 countsByYear W21404485752013 @default.
• W2140448575 countsByYear W21404485752016 @default.
• W2140448575 countsByYear W21404485752018 @default.
• W2140448575 countsByYear W21404485752019 @default.
• W2140448575 countsByYear W21404485752021 @default.
• W2140448575 countsByYear W21404485752023 @default.
• W2140448575 crossrefType "journal-article" @default.
• W2140448575 hasAuthorship W2140448575A5010201728 @default.
• W2140448575 hasAuthorship W2140448575A5012805294 @default.
• W2140448575 hasAuthorship W2140448575A5018536511 @default.
• W2140448575 hasAuthorship W2140448575A5023552802 @default.
• W2140448575 hasAuthorship W2140448575A5032184750 @default.
• W2140448575 hasAuthorship W2140448575A5032410204 @default.
• W2140448575 hasAuthorship W2140448575A5032886139 @default.
• W2140448575 hasAuthorship W2140448575A5037694078 @default.
• W2140448575 hasAuthorship W2140448575A5040756049 @default.
• W2140448575 hasAuthorship W2140448575A5050203564 @default.
• W2140448575 hasAuthorship W2140448575A5052673276 @default.
• W2140448575 hasAuthorship W2140448575A5054047613 @default.
• W2140448575 hasAuthorship W2140448575A5062989284 @default.
• W2140448575 hasAuthorship W2140448575A5067679686 @default.
• W2140448575 hasAuthorship W2140448575A5073306699 @default.
• W2140448575 hasAuthorship W2140448575A5077369264 @default.
• W2140448575 hasBestOaLocation W21404485751 @default.
• W2140448575 hasConcept C126322002 @default.
• W2140448575 hasConcept C138496976 @default.
• W2140448575 hasConcept C143998085 @default.
• W2140448575 hasConcept C15744967 @default.
• W2140448575 hasConcept C207103383 @default.
• W2140448575 hasConcept C2776194465 @default.
• W2140448575 hasConcept C2776694085 @default.
• W2140448575 hasConcept C2776755627 @default.
• W2140448575 hasConcept C2777583451 @default.
• W2140448575 hasConcept C2778461978 @default.
• W2140448575 hasConcept C2778729363 @default.
• W2140448575 hasConcept C2779823535 @default.
• W2140448575 hasConcept C2780007613 @default.
• W2140448575 hasConcept C2781107101 @default.
• W2140448575 hasConcept C2909962599 @default.
• W2140448575 hasConcept C44249647 @default.
• W2140448575 hasConcept C71924100 @default.
• W2140448575 hasConcept C90924648 @default.
• W2140448575 hasConceptScore W2140448575C126322002 @default.
• W2140448575 hasConceptScore W2140448575C138496976 @default.
• W2140448575 hasConceptScore W2140448575C143998085 @default.
• W2140448575 hasConceptScore W2140448575C15744967 @default.
• W2140448575 hasConceptScore W2140448575C207103383 @default.
• W2140448575 hasConceptScore W2140448575C2776194465 @default.
• W2140448575 hasConceptScore W2140448575C2776694085 @default.
• W2140448575 hasConceptScore W2140448575C2776755627 @default.
• W2140448575 hasConceptScore W2140448575C2777583451 @default.

• next