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• W2140465281 startingPage "1303" @default.
• W2140465281 abstract "Introns of four X-linked genes (Hprt, Plp, Glra2, and Amg) were sequenced to provide an estimate of nucleotide diversity at nuclear genes within the house mouse and to test the neutral prediction that the ratio of intraspecific polymorphism to interspecific divergence is the same for different loci. Hprt and Plp lie in a region of the X chromosome that experiences relatively low recombination rates, while Glra2 and Amg lie near the telomere of the X chromosome, a region that experiences higher recombination rates. A total of 6022 bases were sequenced in each of 10 Mus domesticus and one M. caroli. Average nucleotide diversity (π) for introns within M. domesticus was quite low (π = 0.078%). However, there was substantial variation in the level of heterozygosity among loci. The two telomeric loci, Glra2 and Amg, had higher ratios of polymorphism to divergence than the two loci experiencing lower recombination rates. These results are consistent with the hypothesis that heterozygosity is reduced in regions with lower rates of recombination, although sampling of additional genes is needed to establish whether there is a general correlation between heterozygosity and recombination rate as in Drosophila melanogaster." @default.
• W2140465281 created "2016-06-24" @default.
• W2140465281 creator A5072575293 @default.
• W2140465281 date "1997-11-01" @default.
• W2140465281 modified "2023-10-05" @default.
• W2140465281 title "Patterns of DNA Variability at <i>X</i>-Linked Loci in <i>Mus domesticus</i>" @default.
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• W2140465281 doi "https://doi.org/10.1093/genetics/147.3.1303" @default.
• W2140465281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1208253" @default.
• W2140465281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9383072" @default.
• W2140465281 hasPublicationYear "1997" @default.
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