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- W2140473007 abstract "Two forms of radiolabeled creatinine were used in this study, [carbonyl-14C]- and [amidino-14C]creatinine, the latter being synthesized in this laboratory. These labeled compounds were given intravenously to rabbits. Specimens of plasma, urine, feces, and selected tissues were collected. These were liquid-chromatographed and the separated components compared for radioactivity and identity. This first use of amidino-labeled creatinine revealed the metabolic conversion of small amounts of creatinine to an unidentified non-basic compound and guanidinobutyrate in normal rabbits and to guanidinopropionic acid and arginine in a rabbit that had a low creatinine clearance. A mechanism is suggested for this metabolic process. The proposed pathway may be a major route of elimination of creatinine in renal failure." @default.
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- W2140473007 date "1983-07-01" @default.
- W2140473007 modified "2023-09-23" @default.
- W2140473007 title "Metabolism of creatinine in vivo." @default.
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