FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140473103> ?p ?o ?g. }

• W2140473103 endingPage "209" @default.
• W2140473103 startingPage "203" @default.
• W2140473103 abstract "ABSTRACT: An important property of melatonin is that it is a free-radical scavenger or antioxidant. Since free radicals can induce oxidative modification of low-density lipoprotein (LDL), a process believed to be involved in atherogenesis, we were prompted to evaluate the capacity of melatonin to prevent oxidative modification of LDL. To induce oxidation, human LDL (0.4 mg protein/ml) was incubated at 37°C with either 10 μM cupric chloride or 10 mM 2,2′-azo-bis-(2-amidinopropane) dihydrochloride (AAPH) for 3 hr or 24 hr, respectively. Several assays were then performed to unequivocally determine the extent of LDL oxidation. Compared to native LDL, oxidized LDL had increased agarose gel electrophoretic mobility and weaker immunoreactivity with a murine monoclonal antibody to human apolipoprotein B-100. Measurement of thiobarbituric acid-reactive substances (TBARS) revealed that native LDL contained 1.8 ± 0.6 nmoles TBARS/mg protein, whereas copper-oxidized LDL contained 53 ± 4 nmoles TBARS/mg protein. However, when present during incubation, melatonin (0.125–4 mM) inhibited in a concentration-dependent manner the increase in electrophoretic mobility, decrease in immunoreactivity of LDL, and increase in formation of TBARS caused by either copper or AAPH. In a fourth assay, phospholipid analysis of LDL was performed. Native LDL contained 420 ± 9 nmoles phosphatidylcholine (PC)/mg LDL protein and 30 ± 20 nmoles lysophosphatidylcholine (LysPC)/mg LDL protein. LDL incubated with copper had a decreased PC content (276 ± 48 nmoles PC/mg LDL protein) and increased LysPC content (76 ± 22 nmoles LysPC/mg LDL protein). But when present during the incubation of LDL with copper, melatonin attenuated in a concentration-dependent manner the degradation of PC to LysPC. Therefore, we conclude that melatonin can inhibit oxidative modification of LDL in vitro." @default.
• W2140473103 created "2016-06-24" @default.
• W2140473103 creator A5012020242 @default.
• W2140473103 creator A5039823970 @default.
• W2140473103 date "1997-05-01" @default.
• W2140473103 modified "2023-10-03" @default.
• W2140473103 title "Melatonin inhibits oxidative modification of human low-density lipoprotein" @default.
• W2140473103 cites W1988172735 @default.
• W2140473103 cites W1994191432 @default.
• W2140473103 cites W1996726425 @default.
• W2140473103 cites W1997745709 @default.
• W2140473103 cites W2000595788 @default.
• W2140473103 cites W2004021648 @default.
• W2140473103 cites W2010802569 @default.
• W2140473103 cites W2017354690 @default.
• W2140473103 cites W2030566167 @default.
• W2140473103 cites W2031423487 @default.
• W2140473103 cites W2040692157 @default.
• W2140473103 cites W2045096999 @default.
• W2140473103 cites W2056374467 @default.
• W2140473103 cites W2058232887 @default.
• W2140473103 cites W2063678928 @default.
• W2140473103 cites W2064610673 @default.
• W2140473103 cites W2073289405 @default.
• W2140473103 cites W2083259778 @default.
• W2140473103 cites W2087576911 @default.
• W2140473103 cites W2094747686 @default.
• W2140473103 cites W2160593470 @default.
• W2140473103 cites W2170583921 @default.
• W2140473103 cites W2189419402 @default.
• W2140473103 cites W967962159 @default.
• W2140473103 doi "https://doi.org/10.1111/j.1600-079x.1997.tb00323.x" @default.
• W2140473103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9247205" @default.
• W2140473103 hasPublicationYear "1997" @default.
• W2140473103 type Work @default.
• W2140473103 sameAs 2140473103 @default.
• W2140473103 citedByCount "40" @default.
• W2140473103 countsByYear W21404731032012 @default.
• W2140473103 countsByYear W21404731032014 @default.
• W2140473103 countsByYear W21404731032015 @default.
• W2140473103 countsByYear W21404731032016 @default.
• W2140473103 countsByYear W21404731032018 @default.
• W2140473103 countsByYear W21404731032020 @default.
• W2140473103 crossrefType "journal-article" @default.
• W2140473103 hasAuthorship W2140473103A5012020242 @default.
• W2140473103 hasAuthorship W2140473103A5039823970 @default.
• W2140473103 hasConcept C126322002 @default.
• W2140473103 hasConcept C134018914 @default.
• W2140473103 hasConcept C185592680 @default.
• W2140473103 hasConcept C2776330855 @default.
• W2140473103 hasConcept C2777352226 @default.
• W2140473103 hasConcept C2777504301 @default.
• W2140473103 hasConcept C2778004101 @default.
• W2140473103 hasConcept C2778163477 @default.
• W2140473103 hasConcept C2778182776 @default.
• W2140473103 hasConcept C2778596009 @default.
• W2140473103 hasConcept C2778918659 @default.
• W2140473103 hasConcept C2779620165 @default.
• W2140473103 hasConcept C2780072125 @default.
• W2140473103 hasConcept C2780829032 @default.
• W2140473103 hasConcept C41625074 @default.
• W2140473103 hasConcept C55493867 @default.
• W2140473103 hasConcept C57600042 @default.
• W2140473103 hasConcept C62746215 @default.
• W2140473103 hasConcept C71924100 @default.
• W2140473103 hasConcept C86803240 @default.
• W2140473103 hasConceptScore W2140473103C126322002 @default.
• W2140473103 hasConceptScore W2140473103C134018914 @default.
• W2140473103 hasConceptScore W2140473103C185592680 @default.
• W2140473103 hasConceptScore W2140473103C2776330855 @default.
• W2140473103 hasConceptScore W2140473103C2777352226 @default.
• W2140473103 hasConceptScore W2140473103C2777504301 @default.
• W2140473103 hasConceptScore W2140473103C2778004101 @default.
• W2140473103 hasConceptScore W2140473103C2778163477 @default.
• W2140473103 hasConceptScore W2140473103C2778182776 @default.
• W2140473103 hasConceptScore W2140473103C2778596009 @default.
• W2140473103 hasConceptScore W2140473103C2778918659 @default.
• W2140473103 hasConceptScore W2140473103C2779620165 @default.
• W2140473103 hasConceptScore W2140473103C2780072125 @default.
• W2140473103 hasConceptScore W2140473103C2780829032 @default.
• W2140473103 hasConceptScore W2140473103C41625074 @default.
• W2140473103 hasConceptScore W2140473103C55493867 @default.
• W2140473103 hasConceptScore W2140473103C57600042 @default.
• W2140473103 hasConceptScore W2140473103C62746215 @default.
• W2140473103 hasConceptScore W2140473103C71924100 @default.
• W2140473103 hasConceptScore W2140473103C86803240 @default.
• W2140473103 hasIssue "4" @default.
• W2140473103 hasLocation W21404731031 @default.
• W2140473103 hasLocation W21404731032 @default.
• W2140473103 hasOpenAccess W2140473103 @default.
• W2140473103 hasPrimaryLocation W21404731031 @default.
• W2140473103 hasRelatedWork W1915982035 @default.
• W2140473103 hasRelatedWork W1970013882 @default.
• W2140473103 hasRelatedWork W1996561303 @default.
• W2140473103 hasRelatedWork W2012500071 @default.
• W2140473103 hasRelatedWork W2027838892 @default.
• W2140473103 hasRelatedWork W2086575683 @default.
• W2140473103 hasRelatedWork W2196968485 @default.

• next