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- W2140502008 abstract "In this mini review we summarize recent studies from our laboratory that show the involvement of superoxide and the lipid peroxidation product 4-hydroxynonenal in the regulation of mitochondrial uncoupling. Superoxide produced during mitochondrial respiration is a major cause of the cellular oxidative damage that may underlie degenerative diseases and ageing. Superoxide production is very sensitive to the magnitude of the mitochondrial protonmotive force, so can be strongly decreased by mild uncoupling. Superoxide is able to give rise to other reactive oxygen species, which elicit deleterious effects primarily by oxidizing intracellular components, including lipids, DNA and proteins. Superoxide-induced lipid peroxidation leads to the production of reactive aldehydes, including 4-hydroxynonenal. These aldehydic lipid peroxidation products are in turn able to modify proteins such as mitochondrial uncoupling proteins and the adenine nucleotide translocase, converting them into active proton transporters. This activation induces mild uncoupling and so diminishes mitochondrial superoxide production, hence protecting against disease and oxidative damage at the expense of energy production." @default.
- W2140502008 created "2016-06-24" @default.
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- W2140502008 creator A5022521509 @default.
- W2140502008 creator A5081249612 @default.
- W2140502008 creator A5091834634 @default.
- W2140502008 date "2005-01-01" @default.
- W2140502008 modified "2023-10-16" @default.
- W2140502008 title "Hydroxynonenal and uncoupling proteins: A model for protection against oxidative damage" @default.
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- W2140502008 doi "https://doi.org/10.1002/biof.5520240114" @default.
- W2140502008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16403971" @default.
- W2140502008 hasPublicationYear "2005" @default.
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