FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140546604> ?p ?o ?g. }

• W2140546604 endingPage "1054" @default.
• W2140546604 startingPage "1037" @default.
• W2140546604 abstract "A role for cellular inhibitors of apoptosis (IAPs [cIAPs]) in preventing CD95 death has been suspected but not previously explained mechanistically. In this study, we find that the loss of cIAPs leads to a dramatic sensitization to CD95 ligand (CD95L) killing. Surprisingly, this form of cell death can only be blocked by a combination of RIP1 (receptor-interacting protein 1) kinase and caspase inhibitors. Consistently, we detect a large increase in RIP1 levels in the CD95 death-inducing signaling complex (DISC) and in a secondary cytoplasmic complex (complex II) in the presence of IAP antagonists and loss of RIP1-protected cells from CD95L/IAP antagonist-induced death. Cells resistant to CD95L/IAP antagonist treatment could be sensitized by short hairpin RNA-mediated knockdown of cellular FLICE-inhibitory protein (cFLIP). However, only cFLIP(L) and not cFLIP(S) interfered with RIP1 recruitment to the DISC and complex II and protected cells from death. These results demonstrate a fundamental role for RIP1 in CD95 signaling and provide support for a physiological role of caspase-independent death receptor-mediated cell death." @default.
• W2140546604 created "2016-06-24" @default.
• W2140546604 creator A5009074177 @default.
• W2140546604 creator A5019861375 @default.
• W2140546604 creator A5022734188 @default.
• W2140546604 creator A5024429826 @default.
• W2140546604 creator A5042832623 @default.
• W2140546604 creator A5050345393 @default.
• W2140546604 creator A5065391684 @default.
• W2140546604 creator A5079297250 @default.
• W2140546604 creator A5087888938 @default.
• W2140546604 date "2009-12-28" @default.
• W2140546604 modified "2023-10-10" @default.
• W2140546604 title "Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment" @default.
• W2140546604 cites W1523845694 @default.
• W2140546604 cites W1964898521 @default.
• W2140546604 cites W1966106271 @default.
• W2140546604 cites W1967894078 @default.
• W2140546604 cites W1976881265 @default.
• W2140546604 cites W1978525280 @default.
• W2140546604 cites W1979032223 @default.
• W2140546604 cites W1981739287 @default.
• W2140546604 cites W1984937904 @default.
• W2140546604 cites W1992480661 @default.
• W2140546604 cites W1993327789 @default.
• W2140546604 cites W1995177733 @default.
• W2140546604 cites W1996840415 @default.
• W2140546604 cites W1996933769 @default.
• W2140546604 cites W1997321796 @default.
• W2140546604 cites W1997789120 @default.
• W2140546604 cites W1998198750 @default.
• W2140546604 cites W1998422493 @default.
• W2140546604 cites W1998423564 @default.
• W2140546604 cites W200158592 @default.
• W2140546604 cites W2004206170 @default.
• W2140546604 cites W2004233777 @default.
• W2140546604 cites W2004266769 @default.
• W2140546604 cites W2005572311 @default.
• W2140546604 cites W2007731525 @default.
• W2140546604 cites W2012422873 @default.
• W2140546604 cites W2012985988 @default.
• W2140546604 cites W2016883314 @default.
• W2140546604 cites W2024590240 @default.
• W2140546604 cites W2026575658 @default.
• W2140546604 cites W2027021865 @default.
• W2140546604 cites W2028359994 @default.
• W2140546604 cites W2030379432 @default.
• W2140546604 cites W2032872623 @default.
• W2140546604 cites W2033830672 @default.
• W2140546604 cites W2034071655 @default.
• W2140546604 cites W2034269086 @default.
• W2140546604 cites W2034993166 @default.
• W2140546604 cites W2049894488 @default.
• W2140546604 cites W2052605153 @default.
• W2140546604 cites W2052930354 @default.
• W2140546604 cites W2054717287 @default.
• W2140546604 cites W2056641170 @default.
• W2140546604 cites W2056983875 @default.
• W2140546604 cites W2059444339 @default.
• W2140546604 cites W2060204808 @default.
• W2140546604 cites W2060945380 @default.
• W2140546604 cites W2063751527 @default.
• W2140546604 cites W2064299413 @default.
• W2140546604 cites W2069800916 @default.
• W2140546604 cites W2073807266 @default.
• W2140546604 cites W2075520655 @default.
• W2140546604 cites W2081933521 @default.
• W2140546604 cites W2084047756 @default.
• W2140546604 cites W2093475144 @default.
• W2140546604 cites W2095405582 @default.
• W2140546604 cites W2104294370 @default.
• W2140546604 cites W2104553354 @default.
• W2140546604 cites W2110081517 @default.
• W2140546604 cites W2110796758 @default.
• W2140546604 cites W2114727688 @default.
• W2140546604 cites W2116609506 @default.
• W2140546604 cites W2119498734 @default.
• W2140546604 cites W2124202816 @default.
• W2140546604 cites W2124489451 @default.
• W2140546604 cites W2127451431 @default.
• W2140546604 cites W2132014297 @default.
• W2140546604 cites W2136466348 @default.
• W2140546604 cites W2138887185 @default.
• W2140546604 cites W2140433977 @default.
• W2140546604 cites W2142124752 @default.
• W2140546604 cites W2143464311 @default.
• W2140546604 cites W2143937869 @default.
• W2140546604 cites W2148894303 @default.
• W2140546604 cites W2148942767 @default.
• W2140546604 cites W2149144186 @default.
• W2140546604 cites W2149998180 @default.
• W2140546604 cites W2152445095 @default.
• W2140546604 cites W2157201983 @default.
• W2140546604 cites W2158662692 @default.
• W2140546604 cites W2160875934 @default.
• W2140546604 cites W2161830466 @default.
• W2140546604 cites W2165566753 @default.
• W2140546604 doi "https://doi.org/10.1083/jcb.200904158" @default.

• next