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• W2140597941 startingPage "1329" @default.
• W2140597941 abstract "Individual susceptibility to cancer from environmental agents may be influenced by polymorphic metabolic genes such as CYP1A1. The CYP1A1 gene contains four major polymorphisms identified to date. A modern nomenclature system, used with other genes, is presented to clarify the identity of these polymorphisms. The various CYP1A1 alleles exhibit population frequencies that depend on ethnicity. The association of these alleles with cancer at several sites has also been found to depend on racial or ethnic origin of the study population. Statistical considerations, such as the need for large studies when the power to detect a rare polymorphism is low, and ethnic differences in genetic linkage disequilibrium are among possible reasons for ethnic-specific effects on cancer susceptibility related to metabolic gene polymorphisms. New efforts to determine population frequencies of such polymorphisms are essential for future research in this area." @default.
• W2140597941 created "2016-06-24" @default.
• W2140597941 creator A5032422466 @default.
• W2140597941 date "1998-08-01" @default.
• W2140597941 modified "2023-10-03" @default.
• W2140597941 title "The role of ethnicity in cancer susceptibility gene polymorphisms: the example of CYP1A1" @default.
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• W2140597941 doi "https://doi.org/10.1093/carcin/19.8.1329" @default.
• W2140597941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9744524" @default.
• W2140597941 hasPublicationYear "1998" @default.
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