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- W2140636977 abstract "Limited frequencies of T cells express IL-2 in primary antigenic responses, despite activation marker expression and proliferation by most clonal members. To define the basis for restricted IL-2 expression, a videomicroscopic system and IL-2 reporter transgenic model were used to characterize dendritic cell (DC)–T cell interactions. T cells destined to produce IL-2 required prolonged interactions with DCs, whereas most T cells established only transient interactions with DCs and were activated, but did not express IL-2. Extended conjugation of T cells with DCs was not always sufficient to initiate IL-2 expression. Thus, there is intrinsic variability in clonal T cell populations that restricts IL-2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 gene transcription." @default.
- W2140636977 created "2016-06-24" @default.
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- W2140636977 date "2003-06-30" @default.
- W2140636977 modified "2023-10-17" @default.
- W2140636977 title "Restricted Clonal Expression of IL-2 By Naive T Cells Reflects Differential Dynamic Interactions with Dendritic Cells" @default.
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- W2140636977 doi "https://doi.org/10.1084/jem.20022230" @default.
- W2140636977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2196090" @default.
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