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- W2140642124 endingPage "2794" @default.
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- W2140642124 abstract "The translation products of the human coronavirus (HCV) 229E open reading frames 1a and 1b, the polyproteins 1a and 1ab, are processed by virus- encoded proteinases. One of the key enzymes in this process is a chymotrypsin-like enzyme, the 3C- like proteinase. In this study we have identified an ORF 1b-encoded, 41 kDa processing product in HCV 229E-infected cells by using a monoclonal antibody with defined specificity. We show that this polypeptide is released from polyprotein 1ab by 3C-like proteinase-mediated cleavage of the peptide bonds Gln-6110/Gly-6111 and Gln-6458/Ser- 6459. Also, we have investigated the subcellular localization of the 41 kDa processing product. Immunofluorescence microscopy revealed a punctate, perinuclear distribution of the 41 kDa polypeptide in infected cells and an identical subcellular localization was observed for three additional pp1ab-derived polypeptides. In contrast, the virus nucleocapsid protein showed a homogeneous cytoplasmic localization." @default.
- W2140642124 created "2016-06-24" @default.
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- W2140642124 date "1997-11-01" @default.
- W2140642124 modified "2023-09-25" @default.
- W2140642124 title "Identification and subcellular localization of a 41 kDa, polyprotein 1ab processing product in human coronavirus 229E-infected cells." @default.
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- W2140642124 doi "https://doi.org/10.1099/0022-1317-78-11-2789" @default.
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