FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140647566> ?p ?o ?g. }

• W2140647566 endingPage "2267" @default.
• W2140647566 startingPage "2260" @default.
• W2140647566 abstract "Abstract Despite significant advances in the detection and treatment of hepatocellular carcinoma, the prognosis of patients with hepatocellular carcinoma remains very poor, in part due to the high incidence of recurrence. This study was aimed at identifying a prognostic indicator of recurrence in patients with hepatocellular carcinoma. We retrospectively analyzed CpG island hypermethylation of the p14, p15, p16, GSTP1, integrin α4, SYK, and CDH1 genes in fresh-frozen tissues from 265 patients with hepatocellular carcinoma using the methylation-specific PCR. The expression levels of p16 and p53 were evaluated by immunohistochemistry. CpG island hypermethylation was detected in 6% for p14, 21% for p15, 67% for p16, 75% for GSTP1, 23% for integrin α4, 12% for SYK, and 57% for CDH1. Recurrence was observed in 102 (38%) of the 265 patients. There was no association between the risk for recurrence and hypermethylation of any gene studied. However, p16 methylation was associated with a poor survival after surgery for recurrent stage I to II hepatocellular carcinomas (hazard ratio, 4.05; 95% confidence interval, 1.15-14.20; P = 0.03). In addition, the hazard of failure after recurrence was about 3.80 (95% confidence interval, 1.03-14.20; P = 0.04) times higher in patients with p16 methylation than in those without. Negative expression of p16 at a protein level was also associated with poor survival in recurrent stage I to II hepatocellular carcinomas, but p53 expression did not have a synergistic effect on the poor prognosis. In conclusion, the present study suggests that p16 methylation may be associated with a poor prognosis in recurrent early-stage hepatocellular carcinomas. (Cancer Epidemiol Biomarkers Prev 2008;17(9):2260–7)" @default.
• W2140647566 created "2016-06-24" @default.
• W2140647566 creator A5001709379 @default.
• W2140647566 creator A5007024407 @default.
• W2140647566 creator A5016089394 @default.
• W2140647566 creator A5043552754 @default.
• W2140647566 creator A5055492953 @default.
• W2140647566 creator A5059421226 @default.
• W2140647566 creator A5088818732 @default.
• W2140647566 creator A5090619385 @default.
• W2140647566 date "2008-09-01" @default.
• W2140647566 modified "2023-09-26" @default.
• W2140647566 title "Promoter Hypermethylation of the <i>p16</i> Gene Is Associated with Poor Prognosis in Recurrent Early-Stage Hepatocellular Carcinoma" @default.
• W2140647566 cites W1964681228 @default.
• W2140647566 cites W1990508187 @default.
• W2140647566 cites W1994079658 @default.
• W2140647566 cites W1994465394 @default.
• W2140647566 cites W2000940387 @default.
• W2140647566 cites W2013228065 @default.
• W2140647566 cites W2017240003 @default.
• W2140647566 cites W2017846274 @default.
• W2140647566 cites W2020830322 @default.
• W2140647566 cites W2023770133 @default.
• W2140647566 cites W2039463309 @default.
• W2140647566 cites W2044917486 @default.
• W2140647566 cites W2055985776 @default.
• W2140647566 cites W2059530905 @default.
• W2140647566 cites W2066550173 @default.
• W2140647566 cites W2070572466 @default.
• W2140647566 cites W2074004139 @default.
• W2140647566 cites W2088190839 @default.
• W2140647566 cites W2098570030 @default.
• W2140647566 cites W2103637700 @default.
• W2140647566 cites W2114194330 @default.
• W2140647566 cites W2128103809 @default.
• W2140647566 cites W2130570765 @default.
• W2140647566 cites W2135169407 @default.
• W2140647566 cites W2151909352 @default.
• W2140647566 cites W2164247688 @default.
• W2140647566 cites W2165449818 @default.
• W2140647566 cites W2171284757 @default.
• W2140647566 cites W4239180165 @default.
• W2140647566 cites W4302561293 @default.
• W2140647566 doi "https://doi.org/10.1158/1055-9965.epi-08-0236" @default.
• W2140647566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18723830" @default.
• W2140647566 hasPublicationYear "2008" @default.
• W2140647566 type Work @default.
• W2140647566 sameAs 2140647566 @default.
• W2140647566 citedByCount "28" @default.
• W2140647566 countsByYear W21406475662012 @default.
• W2140647566 countsByYear W21406475662013 @default.
• W2140647566 countsByYear W21406475662014 @default.
• W2140647566 countsByYear W21406475662015 @default.
• W2140647566 countsByYear W21406475662016 @default.
• W2140647566 countsByYear W21406475662017 @default.
• W2140647566 countsByYear W21406475662018 @default.
• W2140647566 countsByYear W21406475662019 @default.
• W2140647566 countsByYear W21406475662020 @default.
• W2140647566 countsByYear W21406475662021 @default.
• W2140647566 crossrefType "journal-article" @default.
• W2140647566 hasAuthorship W2140647566A5001709379 @default.
• W2140647566 hasAuthorship W2140647566A5007024407 @default.
• W2140647566 hasAuthorship W2140647566A5016089394 @default.
• W2140647566 hasAuthorship W2140647566A5043552754 @default.
• W2140647566 hasAuthorship W2140647566A5055492953 @default.
• W2140647566 hasAuthorship W2140647566A5059421226 @default.
• W2140647566 hasAuthorship W2140647566A5088818732 @default.
• W2140647566 hasAuthorship W2140647566A5090619385 @default.
• W2140647566 hasBestOaLocation W21406475661 @default.
• W2140647566 hasConcept C104317684 @default.
• W2140647566 hasConcept C126322002 @default.
• W2140647566 hasConcept C135763542 @default.
• W2140647566 hasConcept C140173407 @default.
• W2140647566 hasConcept C143998085 @default.
• W2140647566 hasConcept C146357865 @default.
• W2140647566 hasConcept C150194340 @default.
• W2140647566 hasConcept C151730666 @default.
• W2140647566 hasConcept C190727270 @default.
• W2140647566 hasConcept C207103383 @default.
• W2140647566 hasConcept C2777546739 @default.
• W2140647566 hasConcept C2778019345 @default.
• W2140647566 hasConcept C2780122483 @default.
• W2140647566 hasConcept C33288867 @default.
• W2140647566 hasConcept C44249647 @default.
• W2140647566 hasConcept C502942594 @default.
• W2140647566 hasConcept C50382708 @default.
• W2140647566 hasConcept C55493867 @default.
• W2140647566 hasConcept C71924100 @default.
• W2140647566 hasConcept C86803240 @default.
• W2140647566 hasConcept C90924648 @default.
• W2140647566 hasConceptScore W2140647566C104317684 @default.
• W2140647566 hasConceptScore W2140647566C126322002 @default.
• W2140647566 hasConceptScore W2140647566C135763542 @default.
• W2140647566 hasConceptScore W2140647566C140173407 @default.
• W2140647566 hasConceptScore W2140647566C143998085 @default.
• W2140647566 hasConceptScore W2140647566C146357865 @default.
• W2140647566 hasConceptScore W2140647566C150194340 @default.
• W2140647566 hasConceptScore W2140647566C151730666 @default.

• next