FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140652537> ?p ?o ?g. }

• W2140652537 endingPage "e67937" @default.
• W2140652537 startingPage "e67937" @default.
• W2140652537 abstract "Antilipopolysaccharide factors (ALFs) have been described as highly cationic polypeptides with a broad spectrum of potent antimicrobial activities. In addition, ALFs have been shown to recognize LPS, a major component of the Gram-negative bacteria cell wall, through conserved amino acid residues exposed in the four-stranded β-sheet of their three dimensional structure. In penaeid shrimp, ALFs form a diverse family of antimicrobial peptides composed by three main variants, classified as ALF Groups A to C. Here, we identified a novel group of ALFs in shrimp (Group D ALFs), which corresponds to anionic polypeptides in which many residues of the LPS binding site are lacking. Both Group B (cationic) and Group D (anionic) shrimp ALFs were produced in a heterologous expression system. Group D ALFs were found to have impaired LPS-binding activities and only limited antimicrobial activity compared to Group B ALFs. Interestingly, all four ALF groups were shown to be simultaneously expressed in an individual shrimp and to follow different patterns of gene expression in response to a microbial infection. Group B was by far the more expressed of the ALF genes. From our results, nucleotide sequence variations in shrimp ALFs result in functional divergence, with significant differences in LPS-binding and antimicrobial activities. To our knowledge, this is the first functional characterization of the sequence diversity found in the ALF family." @default.
• W2140652537 created "2016-06-24" @default.
• W2140652537 creator A5004488113 @default.
• W2140652537 creator A5007000398 @default.
• W2140652537 creator A5007597635 @default.
• W2140652537 creator A5018810681 @default.
• W2140652537 creator A5021153520 @default.
• W2140652537 creator A5035909431 @default.
• W2140652537 creator A5041219151 @default.
• W2140652537 creator A5051121656 @default.
• W2140652537 creator A5063689405 @default.
• W2140652537 creator A5067185392 @default.
• W2140652537 creator A5090341151 @default.
• W2140652537 date "2013-07-04" @default.
• W2140652537 modified "2023-10-08" @default.
• W2140652537 title "Functional Divergence in Shrimp Anti-Lipopolysaccharide Factors (ALFs): From Recognition of Cell Wall Components to Antimicrobial Activity" @default.
• W2140652537 cites W132324833 @default.
• W2140652537 cites W1479972543 @default.
• W2140652537 cites W184908838 @default.
• W2140652537 cites W1941810436 @default.
• W2140652537 cites W1964323868 @default.
• W2140652537 cites W1975407634 @default.
• W2140652537 cites W1978799668 @default.
• W2140652537 cites W2006016775 @default.
• W2140652537 cites W2015941374 @default.
• W2140652537 cites W2020799333 @default.
• W2140652537 cites W2022896980 @default.
• W2140652537 cites W2023317697 @default.
• W2140652537 cites W2028031867 @default.
• W2140652537 cites W2028554632 @default.
• W2140652537 cites W2035763040 @default.
• W2140652537 cites W2037145080 @default.
• W2140652537 cites W2053185826 @default.
• W2140652537 cites W2059513578 @default.
• W2140652537 cites W2062205282 @default.
• W2140652537 cites W2064688284 @default.
• W2140652537 cites W2066295351 @default.
• W2140652537 cites W2067957919 @default.
• W2140652537 cites W2077238158 @default.
• W2140652537 cites W2081737708 @default.
• W2140652537 cites W2087289146 @default.
• W2140652537 cites W2089253419 @default.
• W2140652537 cites W2103344958 @default.
• W2140652537 cites W2105439602 @default.
• W2140652537 cites W2107277218 @default.
• W2140652537 cites W2109257698 @default.
• W2140652537 cites W2120245299 @default.
• W2140652537 cites W2125121305 @default.
• W2140652537 cites W2125965145 @default.
• W2140652537 cites W2127034940 @default.
• W2140652537 cites W2128414688 @default.
• W2140652537 cites W2134384430 @default.
• W2140652537 cites W2139089169 @default.
• W2140652537 cites W2160780417 @default.
• W2140652537 cites W2168175505 @default.
• W2140652537 cites W2169278903 @default.
• W2140652537 cites W25506647 @default.
• W2140652537 cites W4238077010 @default.
• W2140652537 cites W4313309903 @default.
• W2140652537 doi "https://doi.org/10.1371/journal.pone.0067937" @default.
• W2140652537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3701609" @default.
• W2140652537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23861837" @default.
• W2140652537 hasPublicationYear "2013" @default.
• W2140652537 type Work @default.
• W2140652537 sameAs 2140652537 @default.
• W2140652537 citedByCount "70" @default.
• W2140652537 countsByYear W21406525372014 @default.
• W2140652537 countsByYear W21406525372015 @default.
• W2140652537 countsByYear W21406525372016 @default.
• W2140652537 countsByYear W21406525372017 @default.
• W2140652537 countsByYear W21406525372018 @default.
• W2140652537 countsByYear W21406525372019 @default.
• W2140652537 countsByYear W21406525372020 @default.
• W2140652537 countsByYear W21406525372021 @default.
• W2140652537 countsByYear W21406525372022 @default.
• W2140652537 countsByYear W21406525372023 @default.
• W2140652537 crossrefType "journal-article" @default.
• W2140652537 hasAuthorship W2140652537A5004488113 @default.
• W2140652537 hasAuthorship W2140652537A5007000398 @default.
• W2140652537 hasAuthorship W2140652537A5007597635 @default.
• W2140652537 hasAuthorship W2140652537A5018810681 @default.
• W2140652537 hasAuthorship W2140652537A5021153520 @default.
• W2140652537 hasAuthorship W2140652537A5035909431 @default.
• W2140652537 hasAuthorship W2140652537A5041219151 @default.
• W2140652537 hasAuthorship W2140652537A5051121656 @default.
• W2140652537 hasAuthorship W2140652537A5063689405 @default.
• W2140652537 hasAuthorship W2140652537A5067185392 @default.
• W2140652537 hasAuthorship W2140652537A5090341151 @default.
• W2140652537 hasBestOaLocation W21406525371 @default.
• W2140652537 hasConcept C104317684 @default.
• W2140652537 hasConcept C167625842 @default.
• W2140652537 hasConcept C18903297 @default.
• W2140652537 hasConcept C2776841996 @default.
• W2140652537 hasConcept C4937899 @default.
• W2140652537 hasConcept C540938839 @default.
• W2140652537 hasConcept C55493867 @default.
• W2140652537 hasConcept C86803240 @default.
• W2140652537 hasConcept C89423630 @default.

• next