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- W2140660145 abstract "There is an urgent need to coat the surfaces of medical devices, including implants, with antimicrobial agents to reduce the risk of infection. A peptide array technology was modified to permit the screening of short peptides for antimicrobial activity while tethered to a surface. Cellulose-amino-hydroxypropyl ether (CAPE) linker chemistry was used to synthesize, on a cellulose support, peptides that remained covalently bound during biological assays. Among 122 tested sequences, the best surface-tethered 9-, 12-, and 13-mer peptides were found to be highly antimicrobial against bacteria and fungi, as confirmed using alternative surface materials and coupling strategies as well as coupling through the C and N termini of the peptides. Structure-activity modeling of the structural features determining the activity of tethered peptides indicated that the extent and positioning of positive charges and hydrophobic residues were influential in determining activity." @default.
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- W2140660145 date "2009-01-01" @default.
- W2140660145 modified "2023-10-08" @default.
- W2140660145 title "Screening and Characterization of Surface-Tethered Cationic Peptides for Antimicrobial Activity" @default.
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- W2140660145 doi "https://doi.org/10.1016/j.chembiol.2008.11.006" @default.
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