FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140679306> ?p ?o ?g. }

• W2140679306 endingPage "240" @default.
• W2140679306 startingPage "229" @default.
• W2140679306 abstract "Communication between various ovarian cell types is a prerequisite for folliculogenesis and ovulation. In antral follicles granulosa cells divide into two distinct populations of mural and cumulus granulosa cells (CGC), enveloping the antrum and surrounding the oocyte, respectively. Both cell types, with the mural compartment in excess, contribute to the floating granulosa cell (FGC) population in the follicular fluid. The aim of this study was to compare the transcriptomes of FGC and CGC in stimulated antral follicles obtained from 19 women undergoing IVF–ICSI procedure. FGC were obtained from follicular fluid during the follicle puncture procedure and CGC were acquired after oocyte denudation for micromanipulation. Gene expression analysis was conducted using the genome-wide Affymetrix transcriptome array. The expression profile of the two granulosa cell populations varied significantly. Out of 28 869 analysed transcripts 4480 were differentially expressed (q-value < 10−4) and 489 showed ≥2-fold difference in the expression level with 222 genes up-regulated in FGC and 267 in CGC. The transcriptome of FGC showed higher expression of genes involved in immune response, hematological system function and organismal injury, although CGC had genes involved in protein degradation and nervous system function up-regulated. Cell-to-cell signalling and interaction pathways were noted in both cell populations. Furthermore, numerous novel transcripts that have not been previously described in follicular physiology were identified. In conclusion, our results provide a solid basis for future studies in follicular biology that will help to identify molecular markers for oocyte and embryo viability in IVF." @default.
• W2140679306 created "2016-06-24" @default.
• W2140679306 creator A5001474940 @default.
• W2140679306 creator A5004932695 @default.
• W2140679306 creator A5023917031 @default.
• W2140679306 creator A5031145843 @default.
• W2140679306 creator A5031853157 @default.
• W2140679306 creator A5037656140 @default.
• W2140679306 creator A5046765788 @default.
• W2140679306 creator A5046840633 @default.
• W2140679306 creator A5057837314 @default.
• W2140679306 creator A5061962903 @default.
• W2140679306 creator A5073972430 @default.
• W2140679306 date "2009-11-20" @default.
• W2140679306 modified "2023-10-03" @default.
• W2140679306 title "The differential transcriptome and ontology profiles of floating and cumulus granulosa cells in stimulated human antral follicles" @default.
• W2140679306 cites W1499718428 @default.
• W2140679306 cites W1964564069 @default.
• W2140679306 cites W1964727206 @default.
• W2140679306 cites W1971365457 @default.
• W2140679306 cites W1975593847 @default.
• W2140679306 cites W1977845454 @default.
• W2140679306 cites W1980556848 @default.
• W2140679306 cites W1981794598 @default.
• W2140679306 cites W1983076004 @default.
• W2140679306 cites W1984924854 @default.
• W2140679306 cites W1987966094 @default.
• W2140679306 cites W1989190177 @default.
• W2140679306 cites W1989434784 @default.
• W2140679306 cites W1990388343 @default.
• W2140679306 cites W1995234849 @default.
• W2140679306 cites W1996549310 @default.
• W2140679306 cites W2000771158 @default.
• W2140679306 cites W2003074850 @default.
• W2140679306 cites W2003103474 @default.
• W2140679306 cites W2003652092 @default.
• W2140679306 cites W2017550401 @default.
• W2140679306 cites W2036377185 @default.
• W2140679306 cites W2036457263 @default.
• W2140679306 cites W2039395012 @default.
• W2140679306 cites W2041655797 @default.
• W2140679306 cites W2043333187 @default.
• W2140679306 cites W2044729985 @default.
• W2140679306 cites W2045580370 @default.
• W2140679306 cites W2048466881 @default.
• W2140679306 cites W2049378885 @default.
• W2140679306 cites W2053398596 @default.
• W2140679306 cites W2054058424 @default.
• W2140679306 cites W2055816275 @default.
• W2140679306 cites W2057811806 @default.
• W2140679306 cites W2062731799 @default.
• W2140679306 cites W2063978487 @default.
• W2140679306 cites W2066664707 @default.
• W2140679306 cites W2072478183 @default.
• W2140679306 cites W2076565229 @default.
• W2140679306 cites W2087263617 @default.
• W2140679306 cites W2087361351 @default.
• W2140679306 cites W2091264269 @default.
• W2140679306 cites W2095949552 @default.
• W2140679306 cites W2104210113 @default.
• W2140679306 cites W2105500778 @default.
• W2140679306 cites W2107007984 @default.
• W2140679306 cites W2107569607 @default.
• W2140679306 cites W2110795667 @default.
• W2140679306 cites W2112271241 @default.
• W2140679306 cites W2116678605 @default.
• W2140679306 cites W2116936982 @default.
• W2140679306 cites W2118085697 @default.
• W2140679306 cites W2123939099 @default.
• W2140679306 cites W2126003141 @default.
• W2140679306 cites W2126364346 @default.
• W2140679306 cites W2129206583 @default.
• W2140679306 cites W2130382653 @default.
• W2140679306 cites W2136625051 @default.
• W2140679306 cites W2137533014 @default.
• W2140679306 cites W2138830670 @default.
• W2140679306 cites W2149342062 @default.
• W2140679306 cites W2149895420 @default.
• W2140679306 cites W2152461738 @default.
• W2140679306 cites W2160251030 @default.
• W2140679306 cites W2161581656 @default.
• W2140679306 cites W2164483834 @default.
• W2140679306 cites W2168432302 @default.
• W2140679306 cites W2170414517 @default.
• W2140679306 cites W2170726898 @default.
• W2140679306 cites W2171630591 @default.
• W2140679306 cites W2172045047 @default.
• W2140679306 cites W2271900218 @default.
• W2140679306 cites W2417251745 @default.
• W2140679306 cites W49774080 @default.
• W2140679306 doi "https://doi.org/10.1093/molehr/gap103" @default.
• W2140679306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19933312" @default.
• W2140679306 hasPublicationYear "2009" @default.
• W2140679306 type Work @default.
• W2140679306 sameAs 2140679306 @default.
• W2140679306 citedByCount "52" @default.
• W2140679306 countsByYear W21406793062012 @default.
• W2140679306 countsByYear W21406793062013 @default.

• next