FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140682015> ?p ?o ?g. }

• W2140682015 endingPage "17" @default.
• W2140682015 startingPage "7" @default.
• W2140682015 abstract "Xenopus nuclear factor 7 (xnf7) is a maternally expressed protein that belongs to the B-box zinc finger gene family consisting of transcription factors, protooncogenes, and ribonucleoproteins. Its function is regulated by retention in the cytoplasm from oocyte maturation until the mid blastula transition (MBT) when it reenters the nucleus. We defined a 22-amino acid cytoplasmic retention domain (CRD) in xnf7 that functioned cooperatively with two phosphorylation sites within the xnf7 molecule to retain the protein in the cytoplasm until the MBT. Deletion of this region or mutations in the phosphorylation sites resulted in the early entry of xnf7 into the nucleus. A mutation changing one of the phosphorylation sites to a glutamic acid resulted in the prolonged retention of the xnf7 protein in the cytoplasm until stages 9-10, well past the MBT. Additionally, a mutant form of xnf7 possessing a second nuclear localization signal at the COOH terminus was retained in the cytoplasm. This suggests that retention of xnf7 was not due to the masking of its NLS as is the case with NFkB and dorsal but was due to a novel anchoring mechanism in which the CRD interacts with an anchor protein. The CRD sequence is also found in another B-box zinc finger protein that is also retained in the cytoplasm until the MBT in the newt. Therefore, we believe that this may be an important mechanism whereby the function of a number of nuclear proteins is regulated during development." @default.
• W2140682015 created "2016-06-24" @default.
• W2140682015 creator A5010229862 @default.
• W2140682015 creator A5019573704 @default.
• W2140682015 creator A5022083915 @default.
• W2140682015 creator A5050786864 @default.
• W2140682015 creator A5077950057 @default.
• W2140682015 date "1994-01-01" @default.
• W2140682015 modified "2023-09-26" @default.
• W2140682015 title "Cytoplasmic retention of Xenopus nuclear factor 7 before the mid blastula transition uses a unique anchoring mechanism involving a retention domain and several phosphorylation sites" @default.
• W2140682015 cites W1213045642 @default.
• W2140682015 cites W1546157935 @default.
• W2140682015 cites W1738521646 @default.
• W2140682015 cites W1829009584 @default.
• W2140682015 cites W1885493605 @default.
• W2140682015 cites W1917787745 @default.
• W2140682015 cites W1975073041 @default.
• W2140682015 cites W1980542111 @default.
• W2140682015 cites W1980614922 @default.
• W2140682015 cites W1981345152 @default.
• W2140682015 cites W1988876993 @default.
• W2140682015 cites W1997646834 @default.
• W2140682015 cites W2005484362 @default.
• W2140682015 cites W2014619010 @default.
• W2140682015 cites W2019894624 @default.
• W2140682015 cites W2037928479 @default.
• W2140682015 cites W2057120350 @default.
• W2140682015 cites W2059851697 @default.
• W2140682015 cites W2062155998 @default.
• W2140682015 cites W2065819477 @default.
• W2140682015 cites W2068767169 @default.
• W2140682015 cites W2069383167 @default.
• W2140682015 cites W2075469212 @default.
• W2140682015 cites W2076505402 @default.
• W2140682015 cites W2077222969 @default.
• W2140682015 cites W2083758347 @default.
• W2140682015 cites W2107332774 @default.
• W2140682015 cites W2126463247 @default.
• W2140682015 cites W2128584338 @default.
• W2140682015 cites W2134399858 @default.
• W2140682015 cites W2135679740 @default.
• W2140682015 cites W2139412961 @default.
• W2140682015 cites W2149093922 @default.
• W2140682015 cites W2152532505 @default.
• W2140682015 cites W2159922116 @default.
• W2140682015 cites W2343337294 @default.
• W2140682015 cites W2421037982 @default.
• W2140682015 cites W94282811 @default.
• W2140682015 doi "https://doi.org/10.1083/jcb.124.1.7" @default.
• W2140682015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119902" @default.
• W2140682015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8294507" @default.
• W2140682015 hasPublicationYear "1994" @default.
• W2140682015 type Work @default.
• W2140682015 sameAs 2140682015 @default.
• W2140682015 citedByCount "62" @default.
• W2140682015 countsByYear W21406820152021 @default.
• W2140682015 crossrefType "journal-article" @default.
• W2140682015 hasAuthorship W2140682015A5010229862 @default.
• W2140682015 hasAuthorship W2140682015A5019573704 @default.
• W2140682015 hasAuthorship W2140682015A5022083915 @default.
• W2140682015 hasAuthorship W2140682015A5050786864 @default.
• W2140682015 hasAuthorship W2140682015A5077950057 @default.
• W2140682015 hasBestOaLocation W21406820151 @default.
• W2140682015 hasConcept C104317684 @default.
• W2140682015 hasConcept C11960822 @default.
• W2140682015 hasConcept C126725582 @default.
• W2140682015 hasConcept C129536746 @default.
• W2140682015 hasConcept C153911025 @default.
• W2140682015 hasConcept C190062978 @default.
• W2140682015 hasConcept C196843134 @default.
• W2140682015 hasConcept C24284526 @default.
• W2140682015 hasConcept C2779535977 @default.
• W2140682015 hasConcept C2780114586 @default.
• W2140682015 hasConcept C29512474 @default.
• W2140682015 hasConcept C49805395 @default.
• W2140682015 hasConcept C5432534 @default.
• W2140682015 hasConcept C54757728 @default.
• W2140682015 hasConcept C55493867 @default.
• W2140682015 hasConcept C59157529 @default.
• W2140682015 hasConcept C6047887 @default.
• W2140682015 hasConcept C67705224 @default.
• W2140682015 hasConcept C68556195 @default.
• W2140682015 hasConcept C75934600 @default.
• W2140682015 hasConcept C86339819 @default.
• W2140682015 hasConcept C86803240 @default.
• W2140682015 hasConcept C87073359 @default.
• W2140682015 hasConcept C95444343 @default.
• W2140682015 hasConceptScore W2140682015C104317684 @default.
• W2140682015 hasConceptScore W2140682015C11960822 @default.
• W2140682015 hasConceptScore W2140682015C126725582 @default.
• W2140682015 hasConceptScore W2140682015C129536746 @default.
• W2140682015 hasConceptScore W2140682015C153911025 @default.
• W2140682015 hasConceptScore W2140682015C190062978 @default.
• W2140682015 hasConceptScore W2140682015C196843134 @default.
• W2140682015 hasConceptScore W2140682015C24284526 @default.
• W2140682015 hasConceptScore W2140682015C2779535977 @default.
• W2140682015 hasConceptScore W2140682015C2780114586 @default.
• W2140682015 hasConceptScore W2140682015C29512474 @default.

• next