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• W2140701635 abstract "<h3>BACKGROUND AND PURPOSE:</h3> DWI using a standard b-value of 1000s/mm² has emerged as the most sensitive sequence for the diagnosis of CJD. The purpose of this study was to investigate whether DWI at a high b-value (<i>b</i> = 3000 s/mm²) and ADC measurements in the basal nuclei improve the diagnosis of vCJD and sCJD compared with visual assessment of DWI at a standard b-value (<i>b</i> = 1000 s/mm²). <h3>MATERIALS AND METHODS:</h3> Eight patients with vCJD, 9 patients with sCJD, and 5 healthy volunteers underwent DWI at <i>b</i> = 1000 s/mm², and 5 vCJD patients, 4 sCJD patients, and 1 growth hormone-related CJD patient underwent DWI at <i>b</i> = 3000 s/mm². Two consultant neuroradiologists performed a visual comparison of the <i>b</i> = 1000 and <i>b</i> = 3000 images. Mean MR SI and ADC values were determined for C, P, and DM thalamus ROIs bilaterally at each b-value. SI ratios for each ROI relative to white matter were calculated. <h3>RESULTS:</h3> In 9 out of 10 patients, the higher b-value images were more sensitive to SI change, particularly in cortex and thalamus, with higher SI ratios at <i>b</i> = 3000 in the DM thalamus. For sCJD at <i>b</i> = 1000, we found significantly lower ADC values in the C and P compared with controls (mean C ADC = 587.3 ± 84.7 mm²/s in sCJD patients versus 722.7 ± 16.6 mm²/s in controls; <i>P</i> = .007), and at <i>b</i> = 3000, the differences were more pronounced. In comparison, in vCJD at <i>b</i> = 1000, ADC values were elevated in the Pu (mean Pu ADC = 837.6 ± 33.0 mm/s² in vCJD patients versus 748.0 ± 17.3 mm/s² in controls; <i>P</i> < .001) but failed to reach significance at <i>b</i> = 3000. <h3>CONCLUSIONS:</h3> Our results demonstrate that <i>b</i> = 3000 DWI, being more sensitive to slowly diffusing tissue water, is more sensitive to pathology in sCJD than is conventional DWI. High-b-value DWI increases confidence in the radiologic diagnosis of human prion disease." @default.
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• W2140701635 date "2009-12-10" @default.
• W2140701635 modified "2023-10-17" @default.
• W2140701635 title "High-b-Value Diffusion MR Imaging and Basal Nuclei Apparent Diffusion Coefficient Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease" @default.
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• W2140701635 doi "https://doi.org/10.3174/ajnr.a1860" @default.
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