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- W2140703352 abstract "This chapter discusses the pathway responsible for formate oxidation in the monkey and presents a comparison between the disposition of formate in the monkey with that of the rat. This information was used to increase and decrease the rate of accumulation of formate in the monkey, and to increase or decrease the sensitivity of the monkey to methanol poisoning. A folate-dependent pathway is the major route of formate metabolism in the monkey. Folate administration to the monkey increases formate oxidation; 4-Methyl pyrazole treatment, after the production of metabolic acidosis and formic acidemia in the monkey, reverses the acidotic state and formic acidemia. Although the folate-deficient monkey is the most sensitive animal toward methanol poisoning, formaldehyde did not appear in the blood, body fluids, or tissues in a study described in the chapter. Formaldehyde does not accumulate in the presence of high methanol and high formate, and reversal of formate accumulation leads to reversal of the features of the methanol poisoning syndrome. Formate, rather than formaldehyde, is the major determinant of methanol poisoning in monkeys and probably in man." @default.
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- W2140703352 date "1977-01-01" @default.
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- W2140703352 title "METHANOL POISONING: ROLE OF FORMATE METABOLISM IN THE MONKEY" @default.
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- W2140703352 doi "https://doi.org/10.1016/b978-0-12-691402-3.50045-7" @default.
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