FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140707911> ?p ?o ?g. }

• W2140707911 endingPage "327" @default.
• W2140707911 startingPage "317" @default.
• W2140707911 abstract "Argania spinosa is an evergreen tree endemic of southwestern Morocco. Many preparations have been used in traditional Moroccan medicine for centuries to treat several illnesses including diabetes. However, scientific evidence supporting these actions is lacking. Therefore, we prepared various extracts of the argan fruit, namely keel, cake and argan oil extracts, which we tested in the HTC hepatoma cell line for their potential to affect cellular insulin responses. Cell viability was measured by Trypan Blue exclusion and the response to insulin evaluated by the activation of the extracellular regulated kinase (ERK1/2), ERK kinase (MEK1/2) and protein kinase B (PKB/Akt) signaling components. None of the extracts demonstrated significant cytotoxic activity. Certain extracts demonstrated a bi-phasic effect on ERK1/2 activation; low doses of the extract slightly increased ERK1/2 activation in response to insulin, whereas higher doses completely abolished the response. In contrast, none of the extracts had any significant effect on MEK whereas only a cake saponin subfraction enhanced insulin-induced PKB/Akt activation. The specific action of argan oil extracts on ERK1/2 activation made us consider an anti-proliferative action. We have thus tested other transformed cell lines (HT-1080 and MSV-MDCK-INV cells) and found similar results. Inhibition of ERK1/2 activation was also associated with decreased DNA synthesis as evidenced by [(3)H]thymidine incorporation experiments. These results suggest that the products of Argania spinosa may provide a new therapeutic avenue against proliferative diseases." @default.
• W2140707911 created "2016-06-24" @default.
• W2140707911 creator A5042751978 @default.
• W2140707911 creator A5054999608 @default.
• W2140707911 creator A5065792608 @default.
• W2140707911 creator A5072862793 @default.
• W2140707911 creator A5090832112 @default.
• W2140707911 date "2006-01-01" @default.
• W2140707911 modified "2023-10-13" @default.
• W2140707911 title "Insulin-sensitizing and Anti-proliferative Effects of Argania spinosa Seed Extracts" @default.
• W2140707911 cites W1593600655 @default.
• W2140707911 cites W1600940594 @default.
• W2140707911 cites W1830337001 @default.
• W2140707911 cites W1865284955 @default.
• W2140707911 cites W1961530921 @default.
• W2140707911 cites W1965489505 @default.
• W2140707911 cites W1973515751 @default.
• W2140707911 cites W1979823716 @default.
• W2140707911 cites W1980414939 @default.
• W2140707911 cites W2000645252 @default.
• W2140707911 cites W2016280713 @default.
• W2140707911 cites W2019013424 @default.
• W2140707911 cites W2020267609 @default.
• W2140707911 cites W2023007685 @default.
• W2140707911 cites W2031263442 @default.
• W2140707911 cites W2034292922 @default.
• W2140707911 cites W2037216049 @default.
• W2140707911 cites W2041742651 @default.
• W2140707911 cites W2042173874 @default.
• W2140707911 cites W2044805610 @default.
• W2140707911 cites W2057154935 @default.
• W2140707911 cites W2058037374 @default.
• W2140707911 cites W2058699484 @default.
• W2140707911 cites W2069423681 @default.
• W2140707911 cites W2074077423 @default.
• W2140707911 cites W2074521053 @default.
• W2140707911 cites W2092037324 @default.
• W2140707911 cites W2097613678 @default.
• W2140707911 cites W2117698956 @default.
• W2140707911 cites W2123241293 @default.
• W2140707911 cites W2125919094 @default.
• W2140707911 cites W2129786920 @default.
• W2140707911 cites W2132499680 @default.
• W2140707911 cites W2137313800 @default.
• W2140707911 cites W2142477983 @default.
• W2140707911 cites W2145954850 @default.
• W2140707911 cites W2157698061 @default.
• W2140707911 cites W2165740104 @default.
• W2140707911 cites W2165845163 @default.
• W2140707911 cites W2288597425 @default.
• W2140707911 cites W2394880292 @default.
• W2140707911 cites W2416325109 @default.
• W2140707911 cites W2466319456 @default.
• W2140707911 cites W69550992 @default.
• W2140707911 cites W2137017932 @default.
• W2140707911 doi "https://doi.org/10.1093/ecam/nel015" @default.
• W2140707911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1513146" @default.
• W2140707911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16951716" @default.
• W2140707911 hasPublicationYear "2006" @default.
• W2140707911 type Work @default.
• W2140707911 sameAs 2140707911 @default.
• W2140707911 citedByCount "62" @default.
• W2140707911 countsByYear W21407079112012 @default.
• W2140707911 countsByYear W21407079112013 @default.
• W2140707911 countsByYear W21407079112014 @default.
• W2140707911 countsByYear W21407079112015 @default.
• W2140707911 countsByYear W21407079112016 @default.
• W2140707911 countsByYear W21407079112017 @default.
• W2140707911 countsByYear W21407079112018 @default.
• W2140707911 countsByYear W21407079112019 @default.
• W2140707911 countsByYear W21407079112020 @default.
• W2140707911 countsByYear W21407079112021 @default.
• W2140707911 countsByYear W21407079112022 @default.
• W2140707911 crossrefType "journal-article" @default.
• W2140707911 hasAuthorship W2140707911A5042751978 @default.
• W2140707911 hasAuthorship W2140707911A5054999608 @default.
• W2140707911 hasAuthorship W2140707911A5065792608 @default.
• W2140707911 hasAuthorship W2140707911A5072862793 @default.
• W2140707911 hasAuthorship W2140707911A5090832112 @default.
• W2140707911 hasBestOaLocation W21407079111 @default.
• W2140707911 hasConcept C134018914 @default.
• W2140707911 hasConcept C184235292 @default.
• W2140707911 hasConcept C185592680 @default.
• W2140707911 hasConcept C190283241 @default.
• W2140707911 hasConcept C2779306644 @default.
• W2140707911 hasConcept C2780070996 @default.
• W2140707911 hasConcept C53227056 @default.
• W2140707911 hasConcept C55493867 @default.
• W2140707911 hasConcept C556039675 @default.
• W2140707911 hasConcept C57074206 @default.
• W2140707911 hasConcept C62112901 @default.
• W2140707911 hasConcept C71924100 @default.
• W2140707911 hasConcept C75217442 @default.
• W2140707911 hasConcept C86803240 @default.
• W2140707911 hasConcept C98274493 @default.
• W2140707911 hasConceptScore W2140707911C134018914 @default.
• W2140707911 hasConceptScore W2140707911C184235292 @default.
• W2140707911 hasConceptScore W2140707911C185592680 @default.

• next