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- W2140728344 abstract "Summary We evaluated urinary neopterin in seven HIV positive children, aged 4 months to 4 years, 11 months, under Zidovudine (AZT) treatment, 300 mg/mq/12 hourly per os. The results were compared with HIV antigenaemia (HIV Ag) and CD4/CD8 ratios. Neopterin (μmol/mol creatinine) was determined by HPLC; HIV Ag assessed by enzyme-immunoassay and T-cell subsets by flow-citometry. Blood and urine samples were obtained before and at 3 and 6 months after starting therapy. There was no significant trend in CD4/CD8 ratios during AZT treatment. Neopterin and HIV Ag showed a statistically significant decrease (median values 3239, 1679, 2062 μmol/mol creatinine; 2.7, 1.3, 1.2 sample optic density/cut off optic density respectively; p < 0.05 by Friedman's test) and were also significantly correlated (p = 0.01 by Spearman's ranks correlation test). We conclude that urinary neopterin is useful in monitoring AZT therapy in HIV positive children." @default.
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- W2140728344 date "1990-09-01" @default.
- W2140728344 modified "2023-09-25" @default.
- W2140728344 title "Urinary Neopterin, Antigenaemia and CD4/CD8 Ratio in HIV Positive Children under AZT Therapy" @default.
- W2140728344 doi "https://doi.org/10.1515/pteridines.1990.2.3.157" @default.
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