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• W2140741653 abstract "During the pilot phase of the NIH Molecular Library Screening Network, the Penn Center for Molecular Discovery focused on a series of projects aimed at high throughput screening and the development of probes of a variety of protease targets. This review provides our medicinal chemistry experience with two such targets--cathepsin B and cathepsin L. We describe our approach for hit validation, characterization and triage that led to a critical understanding of the nature of hits from the cathepsin B project. In addition, we detail our experience at hit identification and optimization that led to the development of a novel thiocarbazate probe of cathepsin L." @default.
• W2140741653 created "2016-06-24" @default.
• W2140741653 creator A5066527875 @default.
• W2140741653 creator A5088980863 @default.
• W2140741653 date "2009-09-01" @default.
• W2140741653 modified "2023-10-18" @default.
• W2140741653 title "The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L" @default.
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• W2140741653 doi "https://doi.org/10.2174/156802609789753653" @default.
• W2140741653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909000" @default.
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