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• W2140757007 abstract "Metazoan cell movement has been studied extensively in vitro, but cell migration in living animals is much less well understood. In this report, we have studied the Caenorhabditis elegans Q neuroblast lineage during larval development, developing live animal imaging methods for following neuroblast migration with single cell resolution. We find that each of the Q descendants migrates at different speeds and for distinct distances. By quantitative green fluorescent protein imaging, we find that Q descendants that migrate faster and longer than their sisters up-regulate protein levels of MIG-2, a Rho family guanosine triphosphatase, and/or down-regulate INA-1, an integrin alpha subunit, during migration. We also show that Q neuroblasts bearing mutations in either MIG-2 or INA-1 migrate at reduced speeds. The migration defect of the mig-2 mutants, but not ina-1, appears to result from a lack of persistent polarization in the direction of cell migration. Thus, MIG-2 and INA-1 function distinctly to control Q neuroblast migration in living C. elegans." @default.
• W2140757007 created "2016-06-24" @default.
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• W2140757007 date "2009-04-06" @default.
• W2140757007 modified "2023-10-03" @default.
• W2140757007 title "Molecular signatures of cell migration in <i>C. elegans</i> Q neuroblasts" @default.
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• W2140757007 doi "https://doi.org/10.1083/jcb.200812077" @default.
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