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- W2140767959 abstract "Background: Nitric oxide (NO) is known to have beneficial effects in ischemia-reperfusion (I/R) injury through maintaining endothelial integrity, inhibiting leukocyte adhesion and platelet aggregation, and inducing vasodilation. The effect of FK409 (FK), a spontaneous NO donor, was investigated in a canine lung transplantation model. Methods Ten pairs of weight-matched dogs were used. Five pairs were assigned to the FK group, to which FK (5 μg/kg/min) was administered intravenously from 30 minutes prior to ischemia until the induction of ischemia in the donor, and from 15 minutes prior to reperfusion until 45 minutes after reperfusion in the recipient. The others were assigned to the control group. After 8-hour preservation in 4° C Euro-Collins solution, orthotopic single-lung transplantation was performed. During a 5-minute clamping test of the right pulmonary artery, left pulmonary arterial pressure (L-PAP), left pulmonary vascular resistance (L-PVR), arterial oxygen pressure (PaO2), and alveolar-arterial oxygen pressure difference (A-aDO2) were measured. The lung specimens were harvested for histologic study, and polymorphonuclear neutrophils (PMNs) were counted. Pulmonary perfusion and ventilation scintigraphy (Tc-99m-MAA and Xe-133) were performed. Results PAP, L-PVR, PaO2, and A-aDO2 revealed significantly (p < 0.05) better function in the FK group than in the control group. Histologically, edema was more mild, and PMN infiltration was significantly (p < 0.05) lower in the FK group than in the control group. Xe-133 and Tc-99m–MAA were widely distributed throughout the graft lung in the FK group. The 2-day survival rate was 100% in the FK group, which was significantly (p < 0.05) better than the rate (40%) in the control group. Conclusions FK appears to generate a protective effect on I/R injury in lung transplantation." @default.
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- W2140767959 date "2000-03-01" @default.
- W2140767959 modified "2023-10-14" @default.
- W2140767959 title "The effect of FK409—a nitric oxide donor—on canine lung transplantation" @default.
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- W2140767959 cites W1969097320 @default.
- W2140767959 cites W1970513735 @default.
- W2140767959 cites W1972035627 @default.
- W2140767959 cites W1973227515 @default.
- W2140767959 cites W1976724002 @default.
- W2140767959 cites W1977826339 @default.
- W2140767959 cites W1979868072 @default.
- W2140767959 cites W1984531009 @default.
- W2140767959 cites W1989167273 @default.
- W2140767959 cites W1992063818 @default.
- W2140767959 cites W1993566814 @default.
- W2140767959 cites W1998874156 @default.
- W2140767959 cites W2007737411 @default.
- W2140767959 cites W2016406628 @default.
- W2140767959 cites W2016782729 @default.
- W2140767959 cites W2019615010 @default.
- W2140767959 cites W2028627259 @default.
- W2140767959 cites W2029047343 @default.
- W2140767959 cites W2029491963 @default.
- W2140767959 cites W2030491466 @default.
- W2140767959 cites W2035615276 @default.
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- W2140767959 cites W2058497094 @default.
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- W2140767959 cites W2065533511 @default.
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- W2140767959 cites W2072580543 @default.
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- W2140767959 doi "https://doi.org/10.1016/s1053-2498(99)00140-0" @default.
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