Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140768597> ?p ?o ?g. }
- W2140768597 endingPage "6040" @default.
- W2140768597 startingPage "6031" @default.
- W2140768597 abstract "Human T-cell leukemia virus type 1 (HTLV-1) has been shown to be the etiologic agent of adult T-cell leukemia (ATL), but the in vivo mechanism by which the virus causes the malignant transformation is largely unknown. In order to investigate the mechanisms of HTLV-1 leukemogenesis, we developed a rat model system in which ATL-like disease was reproducibly observed, following inoculation of various rat HTLV-1-immortalized cell lines. When previously established cell lines, F344-S1 and TARS-1, but not TART-1 or W7TM-1, were inoculated, systemic multiple tumor development was observed in adult nude (nu/nu) rats. FPM1 cells, newly established from a heterozygous (nu/+) rat syngeneic to nu/nu rats, caused transient tumors only at the injection site in adult nu/nu rats, but could progressively grow in newborn nu/nu rats and metastasize in lymph nodes. The derivative cell line (FPM1-V1AX) serially passed through newborn nu/nu rats acquired the potency to grow in adult nu/nu rats. These results indicated that only some with additional changes but not all of the in vitro HTLV-1-immortalized cell lines possessed in vivo tumorigenicity. Using the syngeneic system, we further showed the inhibition of tumor development by transferring splenic T cells from immunized rats, suggesting the involvement of T cells in the regression of tumors. This novel and reproducible nude rat model of human ATL would be useful for investigation of leukemogenesis and antitumor immune responses in HTLV-1 infection." @default.
- W2140768597 created "2016-06-24" @default.
- W2140768597 creator A5004497420 @default.
- W2140768597 creator A5005692384 @default.
- W2140768597 creator A5012836986 @default.
- W2140768597 creator A5015341901 @default.
- W2140768597 creator A5028587082 @default.
- W2140768597 creator A5033931782 @default.
- W2140768597 creator A5056509584 @default.
- W2140768597 creator A5074256930 @default.
- W2140768597 creator A5083607348 @default.
- W2140768597 creator A5091192339 @default.
- W2140768597 date "1999-07-01" @default.
- W2140768597 modified "2023-10-14" @default.
- W2140768597 title "Induction of Adult T-Cell Leukemia-Like Lymphoproliferative Disease and Its Inhibition by Adoptive Immunotherapy in T-Cell-Deficient Nude Rats Inoculated with Syngeneic Human T-Cell Leukemia Virus Type 1-Immortalized Cells" @default.
- W2140768597 cites W1492314296 @default.
- W2140768597 cites W1500263965 @default.
- W2140768597 cites W1524930058 @default.
- W2140768597 cites W1525064523 @default.
- W2140768597 cites W1542367364 @default.
- W2140768597 cites W1594681973 @default.
- W2140768597 cites W171106569 @default.
- W2140768597 cites W1747902446 @default.
- W2140768597 cites W1756114872 @default.
- W2140768597 cites W1979504266 @default.
- W2140768597 cites W1985363326 @default.
- W2140768597 cites W1985893078 @default.
- W2140768597 cites W1989810857 @default.
- W2140768597 cites W1990523305 @default.
- W2140768597 cites W1991941671 @default.
- W2140768597 cites W1997575391 @default.
- W2140768597 cites W2023030366 @default.
- W2140768597 cites W2024949533 @default.
- W2140768597 cites W2030766663 @default.
- W2140768597 cites W2030899646 @default.
- W2140768597 cites W2032913920 @default.
- W2140768597 cites W2033432871 @default.
- W2140768597 cites W2044557464 @default.
- W2140768597 cites W2048022927 @default.
- W2140768597 cites W2054778208 @default.
- W2140768597 cites W2058350611 @default.
- W2140768597 cites W205885975 @default.
- W2140768597 cites W2060437233 @default.
- W2140768597 cites W2066591972 @default.
- W2140768597 cites W2069667541 @default.
- W2140768597 cites W2077509257 @default.
- W2140768597 cites W2084714153 @default.
- W2140768597 cites W2086143621 @default.
- W2140768597 cites W2086270812 @default.
- W2140768597 cites W2088453809 @default.
- W2140768597 cites W2093138378 @default.
- W2140768597 cites W2096036760 @default.
- W2140768597 cites W2099491680 @default.
- W2140768597 cites W2104419866 @default.
- W2140768597 cites W2123679031 @default.
- W2140768597 cites W2131493441 @default.
- W2140768597 cites W2149130930 @default.
- W2140768597 cites W2161052550 @default.
- W2140768597 cites W2166061476 @default.
- W2140768597 cites W2294430528 @default.
- W2140768597 cites W2336865896 @default.
- W2140768597 cites W2400812996 @default.
- W2140768597 cites W2465743609 @default.
- W2140768597 cites W4250178961 @default.
- W2140768597 cites W88146136 @default.
- W2140768597 doi "https://doi.org/10.1128/jvi.73.7.6031-6040.1999" @default.
- W2140768597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/112664" @default.
- W2140768597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10364355" @default.
- W2140768597 hasPublicationYear "1999" @default.
- W2140768597 type Work @default.
- W2140768597 sameAs 2140768597 @default.
- W2140768597 citedByCount "37" @default.
- W2140768597 countsByYear W21407685972012 @default.
- W2140768597 countsByYear W21407685972013 @default.
- W2140768597 countsByYear W21407685972017 @default.
- W2140768597 countsByYear W21407685972020 @default.
- W2140768597 crossrefType "journal-article" @default.
- W2140768597 hasAuthorship W2140768597A5004497420 @default.
- W2140768597 hasAuthorship W2140768597A5005692384 @default.
- W2140768597 hasAuthorship W2140768597A5012836986 @default.
- W2140768597 hasAuthorship W2140768597A5015341901 @default.
- W2140768597 hasAuthorship W2140768597A5028587082 @default.
- W2140768597 hasAuthorship W2140768597A5033931782 @default.
- W2140768597 hasAuthorship W2140768597A5056509584 @default.
- W2140768597 hasAuthorship W2140768597A5074256930 @default.
- W2140768597 hasAuthorship W2140768597A5083607348 @default.
- W2140768597 hasAuthorship W2140768597A5091192339 @default.
- W2140768597 hasBestOaLocation W21407685971 @default.
- W2140768597 hasConcept C1491633281 @default.
- W2140768597 hasConcept C150903083 @default.
- W2140768597 hasConcept C159047783 @default.
- W2140768597 hasConcept C203014093 @default.
- W2140768597 hasConcept C207001950 @default.
- W2140768597 hasConcept C2776090121 @default.
- W2140768597 hasConcept C2776913467 @default.
- W2140768597 hasConcept C2778461978 @default.
- W2140768597 hasConcept C502942594 @default.
- W2140768597 hasConcept C54355233 @default.