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- W2140818339 abstract "Abstract Demethylthio‐, S ‐demethyl‐, and S ‐ethyl derivatives of the α‐mannosidase inhibitor, mannostasin A, were synthesized and evaluated for their inhibition of Jack bean α‐mannosidase with the prime objective of elucidating the role of the methylthio group. All methylthio derivatives had significantly lowered inhibitory potentials. However, one mannostatin A analogue with a methoxyl instead of the methylthio group exhibited about twofold enhancement of the activity. The structure and inhibitory activity relationships of mannostatin A and related compounds are discussed in light of our results. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)" @default.
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- W2140818339 date "2005-09-13" @default.
- W2140818339 modified "2023-09-24" @default.
- W2140818339 title "Chemical Modification of the α-Mannosidase Inhibitor Mannostain A: Synthesis of a Potent Inhibitor 1L-(1,2,3,5/4)-5-Amino-4-O-methyl-1,2,3,4-cyclopentanetetrol" @default.
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- W2140818339 doi "https://doi.org/10.1002/ejoc.200500118" @default.
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