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- W2140866104 endingPage "385" @default.
- W2140866104 startingPage "369" @default.
- W2140866104 abstract "Dyslipoproteinaemia is a cardinal feature of the metabolic syndrome that accelerates atherosclerosis. It is characterized by high plasma concentrations of triglyceride-rich and apolipoprotein (apo) B-containing lipoproteins, with depressed high-density lipoprotein (HDL) and increased small dense low-density lipoprotein (LDL) particle concentrations. Dysregulation of lipoprotein metabolism in the metabolic syndrome may be due to a combination of overproduction of very-low density lipoprotein (VLDL) apoB, decreased catabolism of apoB-containing particles, and increased catabolism of HDL apoA-I particles. These abnormalities are due to a global metabolic effect of insulin resistance and visceral obesity. Lifestyle modifications (dietary restriction and increased exercise) and pharmacological treatments favourably alter lipoprotein transport by decreasing the hepatic secretion of VLDL-apoB and the catabolism of HDL apoA-I, as well as by increasing the clearance of LDL-apoB. The safety and tolerability of combination drug therapy based on statins is important and merits further investigation. There are several pipeline therapies for correcting triglyceride-rich lipoprotein and HDL metabolism. However, their clinical efficacy, safety and cost-effectiveness remain to be demonstrated." @default.
- W2140866104 created "2016-06-24" @default.
- W2140866104 creator A5008118241 @default.
- W2140866104 creator A5055281543 @default.
- W2140866104 creator A5079564889 @default.
- W2140866104 date "2014-06-01" @default.
- W2140866104 modified "2023-10-03" @default.
- W2140866104 title "The metabolic and pharmacologic bases for treating atherogenic dyslipidaemia" @default.
- W2140866104 cites W1275357281 @default.
- W2140866104 cites W1519335354 @default.
- W2140866104 cites W1560062315 @default.
- W2140866104 cites W156853490 @default.
- W2140866104 cites W1900263313 @default.
- W2140866104 cites W1917345819 @default.
- W2140866104 cites W1918701009 @default.
- W2140866104 cites W1924220480 @default.
- W2140866104 cites W1957007052 @default.
- W2140866104 cites W1962202502 @default.
- W2140866104 cites W1975636428 @default.
- W2140866104 cites W1975936284 @default.
- W2140866104 cites W1979536022 @default.
- W2140866104 cites W1980328975 @default.
- W2140866104 cites W1981056002 @default.
- W2140866104 cites W1982444046 @default.
- W2140866104 cites W1987997851 @default.
- W2140866104 cites W1990092121 @default.
- W2140866104 cites W1990106157 @default.
- W2140866104 cites W1999320125 @default.
- W2140866104 cites W2000440477 @default.
- W2140866104 cites W2005504521 @default.
- W2140866104 cites W2005812619 @default.
- W2140866104 cites W2007542782 @default.
- W2140866104 cites W2007746673 @default.
- W2140866104 cites W2009013500 @default.
- W2140866104 cites W2011523747 @default.
- W2140866104 cites W2011760617 @default.
- W2140866104 cites W2012968933 @default.
- W2140866104 cites W2013008998 @default.
- W2140866104 cites W2015925877 @default.
- W2140866104 cites W2017291851 @default.
- W2140866104 cites W2019576699 @default.
- W2140866104 cites W2020143616 @default.
- W2140866104 cites W2020258883 @default.
- W2140866104 cites W2020456860 @default.
- W2140866104 cites W2021879218 @default.
- W2140866104 cites W2027083746 @default.
- W2140866104 cites W2027316231 @default.
- W2140866104 cites W2027797444 @default.
- W2140866104 cites W2030551858 @default.
- W2140866104 cites W2034588349 @default.
- W2140866104 cites W2035730649 @default.
- W2140866104 cites W2035816889 @default.
- W2140866104 cites W2035938675 @default.
- W2140866104 cites W2036747551 @default.
- W2140866104 cites W2037379679 @default.
- W2140866104 cites W2040770080 @default.
- W2140866104 cites W2044842369 @default.
- W2140866104 cites W2045383161 @default.
- W2140866104 cites W2048663697 @default.
- W2140866104 cites W2048903551 @default.
- W2140866104 cites W2054851194 @default.
- W2140866104 cites W2060521284 @default.
- W2140866104 cites W2066568926 @default.
- W2140866104 cites W2071048602 @default.
- W2140866104 cites W2073081893 @default.
- W2140866104 cites W2079968419 @default.
- W2140866104 cites W2081927605 @default.
- W2140866104 cites W2082249494 @default.
- W2140866104 cites W2082272511 @default.
- W2140866104 cites W2086485180 @default.
- W2140866104 cites W2089286420 @default.
- W2140866104 cites W2093260782 @default.
- W2140866104 cites W2093598997 @default.
- W2140866104 cites W2095280703 @default.
- W2140866104 cites W2097716578 @default.
- W2140866104 cites W2097732159 @default.
- W2140866104 cites W2101573428 @default.
- W2140866104 cites W2102941237 @default.
- W2140866104 cites W2102979586 @default.
- W2140866104 cites W2103708195 @default.
- W2140866104 cites W2104086616 @default.
- W2140866104 cites W2107004670 @default.
- W2140866104 cites W2108794637 @default.
- W2140866104 cites W2109129473 @default.
- W2140866104 cites W2112582775 @default.
- W2140866104 cites W2115932847 @default.
- W2140866104 cites W2116876956 @default.
- W2140866104 cites W2118132337 @default.
- W2140866104 cites W2118184073 @default.
- W2140866104 cites W2120220517 @default.
- W2140866104 cites W2120289695 @default.
- W2140866104 cites W2121209370 @default.
- W2140866104 cites W2124481954 @default.
- W2140866104 cites W2125628785 @default.
- W2140866104 cites W2126823382 @default.
- W2140866104 cites W2127432033 @default.
- W2140866104 cites W2128458878 @default.
- W2140866104 cites W2130813021 @default.