FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140914384> ?p ?o ?g. }

• W2140914384 endingPage "1336" @default.
• W2140914384 startingPage "1328" @default.
• W2140914384 abstract "Background and Purpose— To determine whether the receptor for advanced glycation end-products (RAGE) plays a role in early brain injury from intracerebral hemorrhage (ICH), RAGE expression and activation after injury were examined in a rat model of ICH with or without administration of a RAGE-specific antagonist (FPS-ZM1). Methods— Autologous arterial blood was injected into the basal ganglia of rats to induce ICH. The motor function of the rats was examined, and water content was detected after euthanization. Blood–brain barrier permeability was determined by Evans blue staining and colloidal gold nanoparticle tracers. Nerve fiber injury in white matter was determined by diffusion tensor imaging analysis, and the expression of target genes was analyzed by Western blotting and quantitative reverse transcription polymerase chain reaction. FPS-ZM1 was administered by intraperitoneal injection. Results— Expression of RAGE and its ligand high-mobility group protein B1 were increased at 12 hours after ICH, along with blood–brain barrier permeability and perihematomal nerve fiber injury. RAGE and nuclear factor-κB p65 upregulation were also observed when FeCl 2 was infused into the basal ganglia at 24 hours. FPS-ZM1 administration resulted in significant improvements of blood–brain barrier damage, brain edema, motor dysfunction, and nerve fiber injury, and the expression of RAGE, nuclear factor-κB p65, proinflammatory mediators interleukin 1β, interleukin-6, interleukin-8R, cyclooxygenase-2, inducible nitric oxide synthase, and matrix metallopeptidase-9 was attenuated. Moreover, decreases in claudin-5 and occludin expression were partially recovered. FPS-ZM1 also reversed FeCl 2 -induced RAGE and nuclear factor-κB p65 upregulation. Conclusions— RAGE signaling is involved in blood–brain barrier and white matter fiber damage after ICH, the initiation of which is associated with iron. RAGE antagonists represent a novel therapeutic intervention to prevent early brain injury after ICH." @default.
• W2140914384 created "2016-06-24" @default.
• W2140914384 creator A5002260928 @default.
• W2140914384 creator A5004014354 @default.
• W2140914384 creator A5015056816 @default.
• W2140914384 creator A5016467704 @default.
• W2140914384 creator A5021687717 @default.
• W2140914384 creator A5030713034 @default.
• W2140914384 creator A5056053058 @default.
• W2140914384 creator A5084532204 @default.
• W2140914384 date "2015-05-01" @default.
• W2140914384 modified "2023-10-14" @default.
• W2140914384 title "Receptor for Advanced Glycation End-Product Antagonist Reduces Blood–Brain Barrier Damage After Intracerebral Hemorrhage" @default.
• W2140914384 cites W1525214971 @default.
• W2140914384 cites W163988335 @default.
• W2140914384 cites W1965180960 @default.
• W2140914384 cites W1970941053 @default.
• W2140914384 cites W1987417857 @default.
• W2140914384 cites W1992073888 @default.
• W2140914384 cites W2001244796 @default.
• W2140914384 cites W2012763966 @default.
• W2140914384 cites W2021597551 @default.
• W2140914384 cites W2030529426 @default.
• W2140914384 cites W2032613630 @default.
• W2140914384 cites W2034278153 @default.
• W2140914384 cites W2056801657 @default.
• W2140914384 cites W2061415222 @default.
• W2140914384 cites W2062564042 @default.
• W2140914384 cites W2075151875 @default.
• W2140914384 cites W2076533159 @default.
• W2140914384 cites W2079815081 @default.
• W2140914384 cites W2093281069 @default.
• W2140914384 cites W2099171820 @default.
• W2140914384 cites W2099412148 @default.
• W2140914384 cites W2127385733 @default.
• W2140914384 cites W2129855939 @default.
• W2140914384 cites W2131774453 @default.
• W2140914384 cites W2138953837 @default.
• W2140914384 cites W2142123254 @default.
• W2140914384 cites W2142511211 @default.
• W2140914384 cites W2144402067 @default.
• W2140914384 cites W2145132952 @default.
• W2140914384 cites W2147259348 @default.
• W2140914384 cites W2150105859 @default.
• W2140914384 cites W2162189519 @default.
• W2140914384 cites W2168379311 @default.
• W2140914384 cites W4256094090 @default.
• W2140914384 cites W2007963813 @default.
• W2140914384 doi "https://doi.org/10.1161/strokeaha.114.008336" @default.
• W2140914384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25782468" @default.
• W2140914384 hasPublicationYear "2015" @default.
• W2140914384 type Work @default.
• W2140914384 sameAs 2140914384 @default.
• W2140914384 citedByCount "53" @default.
• W2140914384 countsByYear W21409143842016 @default.
• W2140914384 countsByYear W21409143842017 @default.
• W2140914384 countsByYear W21409143842018 @default.
• W2140914384 countsByYear W21409143842019 @default.
• W2140914384 countsByYear W21409143842020 @default.
• W2140914384 countsByYear W21409143842021 @default.
• W2140914384 countsByYear W21409143842022 @default.
• W2140914384 crossrefType "journal-article" @default.
• W2140914384 hasAuthorship W2140914384A5002260928 @default.
• W2140914384 hasAuthorship W2140914384A5004014354 @default.
• W2140914384 hasAuthorship W2140914384A5015056816 @default.
• W2140914384 hasAuthorship W2140914384A5016467704 @default.
• W2140914384 hasAuthorship W2140914384A5021687717 @default.
• W2140914384 hasAuthorship W2140914384A5030713034 @default.
• W2140914384 hasAuthorship W2140914384A5056053058 @default.
• W2140914384 hasAuthorship W2140914384A5084532204 @default.
• W2140914384 hasBestOaLocation W21409143841 @default.
• W2140914384 hasConcept C126322002 @default.
• W2140914384 hasConcept C134018914 @default.
• W2140914384 hasConcept C164027704 @default.
• W2140914384 hasConcept C169760540 @default.
• W2140914384 hasConcept C170493617 @default.
• W2140914384 hasConcept C177779419 @default.
• W2140914384 hasConcept C185592680 @default.
• W2140914384 hasConcept C25498285 @default.
• W2140914384 hasConcept C2775962179 @default.
• W2140914384 hasConcept C2776914184 @default.
• W2140914384 hasConcept C2777094939 @default.
• W2140914384 hasConcept C2777622882 @default.
• W2140914384 hasConcept C2777649898 @default.
• W2140914384 hasConcept C2777736543 @default.
• W2140914384 hasConcept C2778402981 @default.
• W2140914384 hasConcept C2778857457 @default.
• W2140914384 hasConcept C2780545709 @default.
• W2140914384 hasConcept C42219234 @default.
• W2140914384 hasConcept C519581460 @default.
• W2140914384 hasConcept C529278444 @default.
• W2140914384 hasConcept C55493867 @default.
• W2140914384 hasConcept C71924100 @default.
• W2140914384 hasConcept C86803240 @default.
• W2140914384 hasConcept C98274493 @default.
• W2140914384 hasConceptScore W2140914384C126322002 @default.
• W2140914384 hasConceptScore W2140914384C134018914 @default.
• W2140914384 hasConceptScore W2140914384C164027704 @default.

• next