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- W2140918145 abstract "BACKGROUND: Platelet (PLT) collection and storage affect the functional capacity of PLTs in PLT concentrates (PCs). Therefore, PLTs' functional quality should be studied before transfusion. STUDY DESIGN AND METHODS: PCs (n = 15) were collected by a standard apheresis procedure (Trima, Gambro BCT) and were stored for 7 days. Samples were taken to assess PLT adhesion and aggregate formation by a cone and plate analyzer (Impact‐R, DiaMed) on Days 1, 3, 5, and 7 after harvesting. This device allows testing PLT function under high‐shear stress close to physiologic conditions. Concomitantly, P‐selectin expression and the residual responsiveness to TRAP‐6 were determined by flow cytometry. RESULTS: PLT adhesion, as measured by surface coverage, decreased during the entire observation period; likewise, the size of aggregates was significantly lower on Days 5 and 7 compared to Day 1 (p < 0.02). P‐selectin expression increased from Day 5 to Day 7 (p < 0.04), whereas TRAP‐6–inducible expression remained stable until Day 5 of storage and decreased significantly on Day 7 (p = 0.04). CONCLUSIONS: Our results show that high‐shear–induced PLT adhesion and aggregation on the polystyrene surface deteriorate upon storage, suggesting decreased PLT function in vivo. Thus, the Impact‐R may be a useful tool to assess the functional capacity of PLTs under various PLT harvesting and storage procedures." @default.
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- W2140918145 date "2007-09-25" @default.
- W2140918145 modified "2023-10-15" @default.
- W2140918145 title "Platelet function under high‐shear conditions from platelet concentrates" @default.
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- W2140918145 doi "https://doi.org/10.1111/j.1537-2995.2007.01490.x" @default.
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