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• W2140921649 startingPage "3849" @default.
• W2140921649 abstract "Lumican is a keratan sulfate proteoglycan originally identified in cornea, but present in a variety of connective tissues where it presumably regulates collagen fibril formation and organization. The present study was designed to describe the chemical nature of lumican core protein in the aging human sclera.Western blot analyses, immunohistochemistry, and immunoaffinity chromatography were used to detect and purify the lumican core protein from tissue extracts from human donors 6 to 89 years of age. Treatment of lumican with chondroitinase ABC, keratanase-I and -II, and/or endo-beta-galactosidase was used to determine the degree of glycosylation of the lumican core protein.Lumican was present in the human sclera as a 70- to 80-kDa core protein with short unsulfated lactosaminoglycan side chains. In addition, on Western blots, a larger >200-kDa species was apparent that was immunologically related to lumican. This high-molecular-weight material increased in scleral extracts with increasing age. The complex was most abundant in unreduced samples, and approximately two thirds of the 70- to 80-kDa lumican core protein was released from the complex on reduction of the scleral extract. Further characterization of the >200-kDa lumican-immunopurified complex indicated that aggrecan (the cartilage proteoglycan) was covalently associated with lumican.Reducible and nonreducible lumican-aggrecan interactions occur in the scleral extracellular matrix and result in the formation of high-molecular-weight complexes that increase with age. These results represent the first report demonstrating lumican-aggrecan interactions and suggest they may play a role in age-related scleral extracellular matrix changes." @default.
• W2140921649 created "2016-06-24" @default.
• W2140921649 creator A5010522475 @default.
• W2140921649 creator A5081170355 @default.
• W2140921649 date "2004-11-01" @default.
• W2140921649 modified "2023-10-12" @default.
• W2140921649 title "Interaction of Lumican with Aggrecan in the Aging Human Sclera" @default.
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• W2140921649 doi "https://doi.org/10.1167/iovs.04-0496" @default.
• W2140921649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15505028" @default.
• W2140921649 hasPublicationYear "2004" @default.
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