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- W2140931030 endingPage "a017335" @default.
- W2140931030 startingPage "a017335" @default.
- W2140931030 abstract "Pathological neovascularization is a key component of the neovascular form (also known as the wet form) of age-related macular degeneration (AMD) and proliferative diabetic retinopathy. Several preclinical studies have shown that antiangiogenesis strategies are effective for treating neovascular AMD in animal models. Vascular endothelial growth factor (VEGF) is one of the main inducers of ocular neovascularization, and several clinical trials have shown the benefits of neutralizing VEGF in patients with neovascular AMD or diabetic macular edema. In this review, we summarize several preclinical and early-stage clinical trials with intraocular gene therapies, which have the potential to reduce or eliminate the repeated intravitreal injections that are currently required for the treatment of neovascular AMD." @default.
- W2140931030 created "2016-06-24" @default.
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- W2140931030 date "2014-12-18" @default.
- W2140931030 modified "2023-10-14" @default.
- W2140931030 title "Gene Therapies for Neovascular Age-Related Macular Degeneration" @default.
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- W2140931030 doi "https://doi.org/10.1101/cshperspect.a017335" @default.
- W2140931030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4484959" @default.
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