FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140936706> ?p ?o ?g. }

• W2140936706 endingPage "e9875" @default.
• W2140936706 startingPage "e9875" @default.
• W2140936706 abstract "Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone modification. We therefore investigated the effects of H. pylori infection on histone modifications in a global and promoter-specific manner in gastric epithelial cells. Infection of gastric epithelial cells by wild-type H. pylori induced time- and dose-dependent dephosphorylation of histone H3 at serine 10 (H3 Ser10) and decreased acetylation of H3 lysine 23, but had no effects on seven other specific modifications. Different cag pathogenicity island (PAI)-containing-clinical isolates showed similar abilities to induce H3 Ser10 dephosphorylation. Mutation of cagA, vacA, nonphosphorylateable CagA mutant cagAEPISA, or disruption of the flagella showed no effects, while deletion of the entire cagPAI restored the H3 Ser10 phosphorylation to control levels. Analysis of 27 cagPAI mutants indicated that the genes that caused H3 Ser10 dephosphorylation were similar to those that were previously found to induce interleukin-8, irrespective of CagA translocation. This effect was independent of ERK or p38 pathways and type I interferon signaling. Additionally, c-Jun and hsp70 gene expression was associated with this histone modification. These results demonstrate that H. pylori alters histone modification and host response via a cagA-, vacA-independent, but cagPAI-dependent mechanisms, which contribute to its persistent infection and pathogenesis." @default.
• W2140936706 created "2016-06-24" @default.
• W2140936706 creator A5011390932 @default.
• W2140936706 creator A5033108318 @default.
• W2140936706 creator A5046776637 @default.
• W2140936706 creator A5048263933 @default.
• W2140936706 creator A5052328316 @default.
• W2140936706 creator A5055515370 @default.
• W2140936706 creator A5061468745 @default.
• W2140936706 creator A5068619753 @default.
• W2140936706 creator A5071483073 @default.
• W2140936706 creator A5077658794 @default.
• W2140936706 creator A5078961974 @default.
• W2140936706 date "2010-04-01" @default.
• W2140936706 modified "2023-10-16" @default.
• W2140936706 title "Helicobacter pylori-Induced Histone Modification, Associated Gene Expression in Gastric Epithelial Cells, and Its Implication in Pathogenesis" @default.
• W2140936706 cites W1535937129 @default.
• W2140936706 cites W1538891740 @default.
• W2140936706 cites W1593624745 @default.
• W2140936706 cites W1967364632 @default.
• W2140936706 cites W1967784629 @default.
• W2140936706 cites W1974654946 @default.
• W2140936706 cites W1979188601 @default.
• W2140936706 cites W1984517423 @default.
• W2140936706 cites W1986737786 @default.
• W2140936706 cites W1986853519 @default.
• W2140936706 cites W1991444764 @default.
• W2140936706 cites W1993824855 @default.
• W2140936706 cites W1994065276 @default.
• W2140936706 cites W1994975655 @default.
• W2140936706 cites W1999587546 @default.
• W2140936706 cites W2002125536 @default.
• W2140936706 cites W2012731165 @default.
• W2140936706 cites W2015172635 @default.
• W2140936706 cites W2021448147 @default.
• W2140936706 cites W2027151256 @default.
• W2140936706 cites W2028792773 @default.
• W2140936706 cites W2033051264 @default.
• W2140936706 cites W2033059707 @default.
• W2140936706 cites W2040397331 @default.
• W2140936706 cites W2040853949 @default.
• W2140936706 cites W2057857185 @default.
• W2140936706 cites W2062779633 @default.
• W2140936706 cites W2070908216 @default.
• W2140936706 cites W2086343603 @default.
• W2140936706 cites W2087254050 @default.
• W2140936706 cites W2087327203 @default.
• W2140936706 cites W2090681869 @default.
• W2140936706 cites W2093478751 @default.
• W2140936706 cites W2094679140 @default.
• W2140936706 cites W2101171322 @default.
• W2140936706 cites W2105084426 @default.
• W2140936706 cites W2116030323 @default.
• W2140936706 cites W2119614619 @default.
• W2140936706 cites W2129490323 @default.
• W2140936706 cites W2131695415 @default.
• W2140936706 cites W2134310257 @default.
• W2140936706 cites W2142474397 @default.
• W2140936706 cites W2143658931 @default.
• W2140936706 cites W2153336466 @default.
• W2140936706 cites W2154940764 @default.
• W2140936706 cites W2155578687 @default.
• W2140936706 cites W2166424822 @default.
• W2140936706 cites W2169852844 @default.
• W2140936706 doi "https://doi.org/10.1371/journal.pone.0009875" @default.
• W2140936706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2848570" @default.
• W2140936706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20368982" @default.
• W2140936706 hasPublicationYear "2010" @default.
• W2140936706 type Work @default.
• W2140936706 sameAs 2140936706 @default.
• W2140936706 citedByCount "84" @default.
• W2140936706 countsByYear W21409367062012 @default.
• W2140936706 countsByYear W21409367062013 @default.
• W2140936706 countsByYear W21409367062014 @default.
• W2140936706 countsByYear W21409367062015 @default.
• W2140936706 countsByYear W21409367062016 @default.
• W2140936706 countsByYear W21409367062017 @default.
• W2140936706 countsByYear W21409367062018 @default.
• W2140936706 countsByYear W21409367062019 @default.
• W2140936706 countsByYear W21409367062020 @default.
• W2140936706 countsByYear W21409367062021 @default.
• W2140936706 countsByYear W21409367062022 @default.
• W2140936706 countsByYear W21409367062023 @default.
• W2140936706 crossrefType "journal-article" @default.
• W2140936706 hasAuthorship W2140936706A5011390932 @default.
• W2140936706 hasAuthorship W2140936706A5033108318 @default.
• W2140936706 hasAuthorship W2140936706A5046776637 @default.
• W2140936706 hasAuthorship W2140936706A5048263933 @default.
• W2140936706 hasAuthorship W2140936706A5052328316 @default.
• W2140936706 hasAuthorship W2140936706A5055515370 @default.
• W2140936706 hasAuthorship W2140936706A5061468745 @default.
• W2140936706 hasAuthorship W2140936706A5068619753 @default.
• W2140936706 hasAuthorship W2140936706A5071483073 @default.
• W2140936706 hasAuthorship W2140936706A5077658794 @default.
• W2140936706 hasAuthorship W2140936706A5078961974 @default.
• W2140936706 hasBestOaLocation W21409367061 @default.
• W2140936706 hasConcept C104317684 @default.
• W2140936706 hasConcept C119157956 @default.

• next