Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140950633> ?p ?o ?g. }
- W2140950633 endingPage "773" @default.
- W2140950633 startingPage "770" @default.
- W2140950633 abstract "The number of nephrons in humans varies considerably under normal circumstances, and retarded intrauterine growth has been reported to be associated with a significant reduction in nephron number. Low nephron number may be an independent risk factor for the development of hypertension. We therefore decided to evaluate the relationship between body weight at birth and the number and size of nephron units.We examined coronal sections of the kidneys of 35 neonates who died within two weeks of birth because of hyaline membrane, infectious complications, brain hemorrhage, or perinatal hypoxia and had no urinary congenital malformations. Nine of them (5 males and 4 females) were between 36 and 37 weeks of gestation, and the rest had 38 or more weeks of gestation. Eighteen neonates weighed less than 2500 g at birth [low birth weight (LBW); 9 females and 9 males], and 17 had weights above this value [normal birth weight (NBW); 8 females and 9 males]. In each section, glomeruli present in four sequential subcapsular microscopic fields, corresponding to 0.6 mm2, were counted; in addition, the area of each of 65 consecutive glomeruli was determined by a computerized measurement system. Glomerular volume was calculated from the glomerular area. Linear regression analysis was used to test the relationship between glomerular number and size and the weight at birth.The number of glomeruli per 0.6 mm2 of renal cortex was 92.9 +/- 4.85 in the LBW and 105.8 +/- 3.91 in NBW (P < 0.0001). Glomerular volume (micro(3) x 10(-3)) was 529.1 +/- 187.63 in the LBW group and 158.0 +/- 49.89 in the NBW group (P < 0.0001). The glomeruli occupied 8.59 +/- 1.38% of the kidney area under examination in the LBW group and 14.3 +/- 2.75% in the NBW group (P < 0.0001). There were significant direct correlations between the weight at birth and the number of glomeruli (r = 0.870, P < 0.0001) and area occupied by glomeruli (r = 0.935, P < 0.0001). There were inverse correlations between the number of glomeruli and the volume of the glomeruli (r = -0.816, P < 0.0001) and the weight at birth and glomerular volume (r = -0.848, P < 0.0001). These findings were independent of sex and race (black vs. white). Essential arterial hypertension existed in 38.9% of the mothers of children with LBW and in 5.9% of the mothers of children with NBW (P < 0.05). Smoking habits existed in 50% of the mothers of LBW children and in 11.8% of the mothers of NBW children (P < 0.05).There are strong correlations between glomerular number (direct) and size (inverse) with LBW in this cohort. Endowment with decreased nephron numbers may be a risk factor for hypertension and the rate of progression of renal disease." @default.
- W2140950633 created "2016-06-24" @default.
- W2140950633 creator A5015501065 @default.
- W2140950633 creator A5018780890 @default.
- W2140950633 creator A5048103589 @default.
- W2140950633 creator A5052077152 @default.
- W2140950633 creator A5088878161 @default.
- W2140950633 date "2000-08-01" @default.
- W2140950633 modified "2023-10-10" @default.
- W2140950633 title "Relationship between weight at birth and the number and size of renal glomeruli in humans: A histomorphometric study" @default.
- W2140950633 cites W1518743262 @default.
- W2140950633 cites W1937567252 @default.
- W2140950633 cites W1982173374 @default.
- W2140950633 cites W2010636931 @default.
- W2140950633 cites W2019797824 @default.
- W2140950633 cites W2027171099 @default.
- W2140950633 cites W2029978093 @default.
- W2140950633 cites W2035122767 @default.
- W2140950633 cites W2046416492 @default.
- W2140950633 cites W2059368542 @default.
- W2140950633 cites W2077441564 @default.
- W2140950633 cites W2081323233 @default.
- W2140950633 cites W2081523875 @default.
- W2140950633 cites W2093559962 @default.
- W2140950633 cites W2123286906 @default.
- W2140950633 cites W2327719079 @default.
- W2140950633 doi "https://doi.org/10.1046/j.1523-1755.2000.00225.x" @default.
- W2140950633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10916101" @default.
- W2140950633 hasPublicationYear "2000" @default.
- W2140950633 type Work @default.
- W2140950633 sameAs 2140950633 @default.
- W2140950633 citedByCount "524" @default.
- W2140950633 countsByYear W21409506332012 @default.
- W2140950633 countsByYear W21409506332013 @default.
- W2140950633 countsByYear W21409506332014 @default.
- W2140950633 countsByYear W21409506332015 @default.
- W2140950633 countsByYear W21409506332016 @default.
- W2140950633 countsByYear W21409506332017 @default.
- W2140950633 countsByYear W21409506332018 @default.
- W2140950633 countsByYear W21409506332019 @default.
- W2140950633 countsByYear W21409506332020 @default.
- W2140950633 countsByYear W21409506332021 @default.
- W2140950633 countsByYear W21409506332022 @default.
- W2140950633 countsByYear W21409506332023 @default.
- W2140950633 crossrefType "journal-article" @default.
- W2140950633 hasAuthorship W2140950633A5015501065 @default.
- W2140950633 hasAuthorship W2140950633A5018780890 @default.
- W2140950633 hasAuthorship W2140950633A5048103589 @default.
- W2140950633 hasAuthorship W2140950633A5052077152 @default.
- W2140950633 hasAuthorship W2140950633A5088878161 @default.
- W2140950633 hasBestOaLocation W21409506331 @default.
- W2140950633 hasConcept C105702510 @default.
- W2140950633 hasConcept C118494813 @default.
- W2140950633 hasConcept C126322002 @default.
- W2140950633 hasConcept C126894567 @default.
- W2140950633 hasConcept C134018914 @default.
- W2140950633 hasConcept C13483470 @default.
- W2140950633 hasConcept C142724271 @default.
- W2140950633 hasConcept C159641895 @default.
- W2140950633 hasConcept C2776993930 @default.
- W2140950633 hasConcept C2777501473 @default.
- W2140950633 hasConcept C2779083892 @default.
- W2140950633 hasConcept C2779234561 @default.
- W2140950633 hasConcept C2781231759 @default.
- W2140950633 hasConcept C42407357 @default.
- W2140950633 hasConcept C46973012 @default.
- W2140950633 hasConcept C54355233 @default.
- W2140950633 hasConcept C66322754 @default.
- W2140950633 hasConcept C71924100 @default.
- W2140950633 hasConcept C77411442 @default.
- W2140950633 hasConcept C86803240 @default.
- W2140950633 hasConceptScore W2140950633C105702510 @default.
- W2140950633 hasConceptScore W2140950633C118494813 @default.
- W2140950633 hasConceptScore W2140950633C126322002 @default.
- W2140950633 hasConceptScore W2140950633C126894567 @default.
- W2140950633 hasConceptScore W2140950633C134018914 @default.
- W2140950633 hasConceptScore W2140950633C13483470 @default.
- W2140950633 hasConceptScore W2140950633C142724271 @default.
- W2140950633 hasConceptScore W2140950633C159641895 @default.
- W2140950633 hasConceptScore W2140950633C2776993930 @default.
- W2140950633 hasConceptScore W2140950633C2777501473 @default.
- W2140950633 hasConceptScore W2140950633C2779083892 @default.
- W2140950633 hasConceptScore W2140950633C2779234561 @default.
- W2140950633 hasConceptScore W2140950633C2781231759 @default.
- W2140950633 hasConceptScore W2140950633C42407357 @default.
- W2140950633 hasConceptScore W2140950633C46973012 @default.
- W2140950633 hasConceptScore W2140950633C54355233 @default.
- W2140950633 hasConceptScore W2140950633C66322754 @default.
- W2140950633 hasConceptScore W2140950633C71924100 @default.
- W2140950633 hasConceptScore W2140950633C77411442 @default.
- W2140950633 hasConceptScore W2140950633C86803240 @default.
- W2140950633 hasIssue "2" @default.
- W2140950633 hasLocation W21409506331 @default.
- W2140950633 hasLocation W21409506332 @default.
- W2140950633 hasOpenAccess W2140950633 @default.
- W2140950633 hasPrimaryLocation W21409506331 @default.
- W2140950633 hasRelatedWork W1969005723 @default.
- W2140950633 hasRelatedWork W2029803385 @default.