Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140957276> ?p ?o ?g. }
- W2140957276 endingPage "3305" @default.
- W2140957276 startingPage "3295" @default.
- W2140957276 abstract "Several genes have been identified that are activated or repressed by thyroid hormone in tadpole tissues during metamorphosis of the frog Xenopus laevis. One rapidly and strongly induced gene encodes the Xenopus homolog of basic transcription element-binding protein 1 (xBTEB1), an SP1-related transcription factor. xBTEB1 has similar DNA-binding activity and transcriptional activation properties as mammalian BTEB1. The thyroid hormone-dependent regulation of xBTEB1 was investigated using a modified electrophoretic mobility shift assay to scan genomic DNA for receptor-binding sites. Due to the tetraploid X. laevis genome, xBTEB1 is duplicated, and thyroid hormone regulates both copies. A consensus thyroid hormone response element (TRE) lies far upstream of the transcriptional start site of both genes. The TRE is nested within a 200-bp region of high sequence conservation between these two genes that duplicated millions of years ago. The TRE acts as a strong response element in transfection assays using a heterologous promoter or its native context. Thus, one of the earliest thyroid hormone-induced genes in tadpoles is a transcription factor regulated through an evolutionarily conserved TRE. xBTEB1 is predicted to play an important role in downstream gene regulation leading to the growth and remodeling of tissues at metamorphosis." @default.
- W2140957276 created "2016-06-24" @default.
- W2140957276 creator A5017515823 @default.
- W2140957276 creator A5019835159 @default.
- W2140957276 date "2002-09-01" @default.
- W2140957276 modified "2023-09-26" @default.
- W2140957276 title "The Transcription Factor Basic Transcription Element-Binding Protein 1 Is a Direct Thyroid Hormone Response Gene in the Frog Xenopus laevis" @default.
- W2140957276 cites W1498184124 @default.
- W2140957276 cites W1531600133 @default.
- W2140957276 cites W1543374674 @default.
- W2140957276 cites W1557168768 @default.
- W2140957276 cites W1583559371 @default.
- W2140957276 cites W1598045648 @default.
- W2140957276 cites W1663165115 @default.
- W2140957276 cites W1764388483 @default.
- W2140957276 cites W1948303521 @default.
- W2140957276 cites W195983064 @default.
- W2140957276 cites W1969633505 @default.
- W2140957276 cites W1973982400 @default.
- W2140957276 cites W1981224408 @default.
- W2140957276 cites W1981349281 @default.
- W2140957276 cites W1981474173 @default.
- W2140957276 cites W1987355577 @default.
- W2140957276 cites W1992369902 @default.
- W2140957276 cites W1999393423 @default.
- W2140957276 cites W1999694266 @default.
- W2140957276 cites W2005724129 @default.
- W2140957276 cites W2021336091 @default.
- W2140957276 cites W2023999213 @default.
- W2140957276 cites W2029156388 @default.
- W2140957276 cites W2035721071 @default.
- W2140957276 cites W2039455433 @default.
- W2140957276 cites W2058426472 @default.
- W2140957276 cites W2062599461 @default.
- W2140957276 cites W2071318680 @default.
- W2140957276 cites W2071462924 @default.
- W2140957276 cites W2077504048 @default.
- W2140957276 cites W2083496955 @default.
- W2140957276 cites W2092030652 @default.
- W2140957276 cites W2092294603 @default.
- W2140957276 cites W2101599514 @default.
- W2140957276 cites W2111052846 @default.
- W2140957276 cites W2112414494 @default.
- W2140957276 cites W2115940794 @default.
- W2140957276 cites W2130929794 @default.
- W2140957276 cites W2132129924 @default.
- W2140957276 cites W2144829665 @default.
- W2140957276 cites W2149235949 @default.
- W2140957276 cites W2149935989 @default.
- W2140957276 cites W2171195379 @default.
- W2140957276 cites W59445655 @default.
- W2140957276 doi "https://doi.org/10.1210/en.2002-220126" @default.
- W2140957276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12193541" @default.
- W2140957276 hasPublicationYear "2002" @default.
- W2140957276 type Work @default.
- W2140957276 sameAs 2140957276 @default.
- W2140957276 citedByCount "50" @default.
- W2140957276 countsByYear W21409572762012 @default.
- W2140957276 countsByYear W21409572762014 @default.
- W2140957276 countsByYear W21409572762015 @default.
- W2140957276 countsByYear W21409572762016 @default.
- W2140957276 countsByYear W21409572762017 @default.
- W2140957276 countsByYear W21409572762019 @default.
- W2140957276 countsByYear W21409572762020 @default.
- W2140957276 countsByYear W21409572762021 @default.
- W2140957276 countsByYear W21409572762022 @default.
- W2140957276 countsByYear W21409572762023 @default.
- W2140957276 crossrefType "journal-article" @default.
- W2140957276 hasAuthorship W2140957276A5017515823 @default.
- W2140957276 hasAuthorship W2140957276A5019835159 @default.
- W2140957276 hasBestOaLocation W21409572761 @default.
- W2140957276 hasConcept C101762097 @default.
- W2140957276 hasConcept C104317684 @default.
- W2140957276 hasConcept C109115496 @default.
- W2140957276 hasConcept C121608353 @default.
- W2140957276 hasConcept C132376346 @default.
- W2140957276 hasConcept C138885662 @default.
- W2140957276 hasConcept C150194340 @default.
- W2140957276 hasConcept C153911025 @default.
- W2140957276 hasConcept C179926584 @default.
- W2140957276 hasConcept C2779535977 @default.
- W2140957276 hasConcept C41895202 @default.
- W2140957276 hasConcept C51445715 @default.
- W2140957276 hasConcept C530470458 @default.
- W2140957276 hasConcept C54355233 @default.
- W2140957276 hasConcept C84606932 @default.
- W2140957276 hasConcept C86339819 @default.
- W2140957276 hasConcept C86803240 @default.
- W2140957276 hasConcept C95444343 @default.
- W2140957276 hasConceptScore W2140957276C101762097 @default.
- W2140957276 hasConceptScore W2140957276C104317684 @default.
- W2140957276 hasConceptScore W2140957276C109115496 @default.
- W2140957276 hasConceptScore W2140957276C121608353 @default.
- W2140957276 hasConceptScore W2140957276C132376346 @default.
- W2140957276 hasConceptScore W2140957276C138885662 @default.
- W2140957276 hasConceptScore W2140957276C150194340 @default.
- W2140957276 hasConceptScore W2140957276C153911025 @default.
- W2140957276 hasConceptScore W2140957276C179926584 @default.