FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140978864> ?p ?o ?g. }

• W2140978864 abstract "The liver is responsible for controlling cholesterol homeostasis in the body. HMG-CoA reductase and the LDL receptor (LDL-r) are involved in this regulation and are also ubiquitously expressed in all major tissues. We have previously shown in guinea pigs that there is a correlation in gene expression of HMG-CoA reductase and the LDL-r between liver and mononuclear cells. The present study evaluated human mononuclear cells as a surrogate for hepatic expression of these genes. The purpose was to evaluate the effect of dietary carbohydrate restriction with low and high cholesterol content on HMG-CoA reductase and LDL-r mRNA expression in mononuclear cells. All subjects were counseled to consume a carbohydrate restricted diet with 10-15% energy from carbohydrate, 30-35% energy from protein and 55-60% energy from fat. Subjects were randomly assigned to either EGG (640 mg/d additional dietary cholesterol) or SUB groups [equivalent amount of egg substitute (0 dietary cholesterol contributions) per day] for 12 weeks. At the end of the intervention, there were no changes in plasma total or LDL cholesterol (LDL-C) compared to baseline (P > 0.10) or differences in plasma total or LDL-C between groups. The mRNA abundance for HMG-CoA reductase and LDL-r were measured in mononuclear cells using real time PCR. The EGG group showed a significant decrease in HMG-CoA reductase mRNA (1.98 +/- 1.26 to 1.32 +/- 0.92 arbitrary units P < 0.05) while an increase was observed for the SUB group (1.13 +/- 0.52 to 1.69 +/- 1.61 arbitrary units P < 0.05). Additionally, the LDL-r mRNA abundance was decreased in the EGG group (1.72 +/- 0.69 to 1.24 +/- 0.55 arbitrary units P < 0.05) and significantly increased in the SUB group (1.00 +/- 0.60 to 1.67 +/- 1.94 arbitrary units P < 0.05). The findings indicate that dietary cholesterol during a weight loss intervention alters the expression of genes regulating cholesterol homeostasis." @default.
• W2140978864 created "2016-06-24" @default.
• W2140978864 creator A5017102102 @default.
• W2140978864 creator A5066370954 @default.
• W2140978864 creator A5071325145 @default.
• W2140978864 creator A5081121953 @default.
• W2140978864 creator A5083621124 @default.
• W2140978864 date "2007-11-28" @default.
• W2140978864 modified "2023-10-16" @default.
• W2140978864 title "Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult men" @default.
• W2140978864 cites W1571071722 @default.
• W2140978864 cites W1657550065 @default.
• W2140978864 cites W1902852842 @default.
• W2140978864 cites W1963648327 @default.
• W2140978864 cites W1968258220 @default.
• W2140978864 cites W1970541648 @default.
• W2140978864 cites W1990394752 @default.
• W2140978864 cites W1998600489 @default.
• W2140978864 cites W2006467904 @default.
• W2140978864 cites W2025646685 @default.
• W2140978864 cites W2058161009 @default.
• W2140978864 cites W2084744450 @default.
• W2140978864 cites W2096475643 @default.
• W2140978864 cites W2131517844 @default.
• W2140978864 cites W2139319270 @default.
• W2140978864 cites W2146908491 @default.
• W2140978864 cites W2152544605 @default.
• W2140978864 cites W2156799866 @default.
• W2140978864 cites W2163265097 @default.
• W2140978864 cites W4246241915 @default.
• W2140978864 cites W4294216491 @default.
• W2140978864 doi "https://doi.org/10.1186/1476-511x-6-34" @default.
• W2140978864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2222226" @default.
• W2140978864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18045475" @default.
• W2140978864 hasPublicationYear "2007" @default.
• W2140978864 type Work @default.
• W2140978864 sameAs 2140978864 @default.
• W2140978864 citedByCount "14" @default.
• W2140978864 countsByYear W21409788642012 @default.
• W2140978864 countsByYear W21409788642015 @default.
• W2140978864 countsByYear W21409788642017 @default.
• W2140978864 countsByYear W21409788642018 @default.
• W2140978864 countsByYear W21409788642020 @default.
• W2140978864 countsByYear W21409788642021 @default.
• W2140978864 countsByYear W21409788642022 @default.
• W2140978864 crossrefType "journal-article" @default.
• W2140978864 hasAuthorship W2140978864A5017102102 @default.
• W2140978864 hasAuthorship W2140978864A5066370954 @default.
• W2140978864 hasAuthorship W2140978864A5071325145 @default.
• W2140978864 hasAuthorship W2140978864A5081121953 @default.
• W2140978864 hasAuthorship W2140978864A5083621124 @default.
• W2140978864 hasBestOaLocation W21409788641 @default.
• W2140978864 hasConcept C104950815 @default.
• W2140978864 hasConcept C126322002 @default.
• W2140978864 hasConcept C134018914 @default.
• W2140978864 hasConcept C134651460 @default.
• W2140978864 hasConcept C137061746 @default.
• W2140978864 hasConcept C181199279 @default.
• W2140978864 hasConcept C202751555 @default.
• W2140978864 hasConcept C22894154 @default.
• W2140978864 hasConcept C2777320049 @default.
• W2140978864 hasConcept C2778163477 @default.
• W2140978864 hasConcept C2780072125 @default.
• W2140978864 hasConcept C382228 @default.
• W2140978864 hasConcept C43554185 @default.
• W2140978864 hasConcept C55493867 @default.
• W2140978864 hasConcept C71924100 @default.
• W2140978864 hasConcept C86803240 @default.
• W2140978864 hasConceptScore W2140978864C104950815 @default.
• W2140978864 hasConceptScore W2140978864C126322002 @default.
• W2140978864 hasConceptScore W2140978864C134018914 @default.
• W2140978864 hasConceptScore W2140978864C134651460 @default.
• W2140978864 hasConceptScore W2140978864C137061746 @default.
• W2140978864 hasConceptScore W2140978864C181199279 @default.
• W2140978864 hasConceptScore W2140978864C202751555 @default.
• W2140978864 hasConceptScore W2140978864C22894154 @default.
• W2140978864 hasConceptScore W2140978864C2777320049 @default.
• W2140978864 hasConceptScore W2140978864C2778163477 @default.
• W2140978864 hasConceptScore W2140978864C2780072125 @default.
• W2140978864 hasConceptScore W2140978864C382228 @default.
• W2140978864 hasConceptScore W2140978864C43554185 @default.
• W2140978864 hasConceptScore W2140978864C55493867 @default.
• W2140978864 hasConceptScore W2140978864C71924100 @default.
• W2140978864 hasConceptScore W2140978864C86803240 @default.
• W2140978864 hasIssue "1" @default.
• W2140978864 hasLocation W21409788641 @default.
• W2140978864 hasLocation W21409788642 @default.
• W2140978864 hasLocation W21409788643 @default.
• W2140978864 hasLocation W21409788644 @default.
• W2140978864 hasOpenAccess W2140978864 @default.
• W2140978864 hasPrimaryLocation W21409788641 @default.
• W2140978864 hasRelatedWork W1966834268 @default.
• W2140978864 hasRelatedWork W2026060498 @default.
• W2140978864 hasRelatedWork W2030755023 @default.
• W2140978864 hasRelatedWork W2042300657 @default.
• W2140978864 hasRelatedWork W2052795006 @default.
• W2140978864 hasRelatedWork W2108803894 @default.
• W2140978864 hasRelatedWork W2110293002 @default.
• W2140978864 hasRelatedWork W2140978864 @default.
• W2140978864 hasRelatedWork W2163340289 @default.

• next