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• W2140979159 abstract "The tumor suppressor and microtubule-associated protein Ras association domain family 1A (RASSF1A) has a major effect on many cellular processes, such as cell cycle progression and apoptosis. RASSF1A expression is frequently silenced in cancer and is associated with increased metastasis. Therefore we tested the hypothesis that RASSF1A regulates microtubule organization and dynamics in interphase cells, as well as its effect on Golgi integrity and cell polarity. Our results show that RASSF1A uses a unique microtubule-binding pattern to promote site-specific microtubule rescues, and loss of RASSF1A leads to decreased microtubule stability. Furthermore, RASSF1A-associated stable microtubule segments are necessary to prevent Golgi fragmentation and dispersal in cancer cells and maintain a polarized cell front. These results indicate that RASSF1A is a key regulator in the fine tuning of microtubule dynamics in interphase cells and proper Golgi organization and cell polarity." @default.
• W2140979159 created "2016-06-24" @default.
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• W2140979159 date "2014-03-15" @default.
• W2140979159 modified "2023-10-14" @default.
• W2140979159 title "Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi integrity" @default.
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• W2140979159 doi "https://doi.org/10.1091/mbc.e13-07-0374" @default.
• W2140979159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3952850" @default.
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• W2140979159 hasPublicationYear "2014" @default.
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