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• W2140986194 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Apr 2001THE USE OF HYDROGEN PEROXIDE TO ENHANCE THE EFFICACY OF DOXORUBICIN HYDROCHLORIDE IN A MURINE BLADDER TUMOR CELL LINE KEVIN R. LOUGHLIN, KELLEDY MANSON, DINO CRAGNALE, LISE WILSON, ROBERT A. BALL, and KENNETH R. BRIDGES KEVIN R. LOUGHLINKEVIN R. LOUGHLIN More articles by this author , KELLEDY MANSONKELLEDY MANSON More articles by this author , DINO CRAGNALEDINO CRAGNALE More articles by this author , LISE WILSONLISE WILSON More articles by this author , ROBERT A. BALLROBERT A. BALL More articles by this author , and KENNETH R. BRIDGESKENNETH R. BRIDGES More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69888-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether the cytotoxicity of doxorubicin hydrochloride would be enhanced by adding hydrogen peroxide as a source of oxygen free radicals. Materials and Methods: Mouse bladder tumor cells (MBT-2) were grown in RPMI 1640 medium and treated with various concentrations of doxorubicin hydrochloride for 2 hours. Protein content was assayed as a measure of cell growth. A similar set of experiments was done with cells exposed to hydrogen peroxide only and combined doxorubicin and hydrogen peroxide. Protein content was again assayed as a measure of cell growth. Cells were also assayed for glutathione peroxidase and malonyl dialdehyde, a product of lipid peroxidation, to determine the mechanism of cell damage. Furthermore, MBT-2 cells were incubated with 100 M. α-tocopherol, a free radical scavenger, before exposure to hydrogen peroxide to determine whether the effects of hydrogen peroxide could be reversed. Results: We observed a dose dependent inhibition of MBT-2 cell growth after exposure to doxorubicin hydrochloride. Exposure to doxorubicin and hydrogen peroxide resulted in greater cell growth inhibition than exposure to either agent alone. The effects of hydrogen peroxide on cell proliferation were reversed by pre-incubation with α-tocopherol. Conclusions: As a source of oxygen free radicals, hydrogen peroxide enhances the antiproliferative effect of doxorubicin hydrochloride on a mouse bladder tumor cell line. Thus, hydrogen peroxide may be a relatively inexpensive, nontoxic method of augmenting the cytotoxicity of doxorubicin hydrochloride. Further studies are warranted to determine whether these observations may have clinical application. References 1 : Cancer statistics 1999. 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Volume 165Issue 4April 2001Page: 1300-1304 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsmice, inbred C3Hhydrogen peroxidebladderdoxorubicinbladder neoplasmsMetrics Author Information KEVIN R. LOUGHLIN More articles by this author KELLEDY MANSON More articles by this author DINO CRAGNALE More articles by this author LISE WILSON More articles by this author ROBERT A. BALL More articles by this author KENNETH R. BRIDGES More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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