FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140989076> ?p ?o ?g. }

• W2140989076 endingPage "516" @default.
• W2140989076 startingPage "509" @default.
• W2140989076 abstract "Inactivation of the cell cycle inhibitor gene p16MTS1 seems to be involved in human papillomavirus (HPV)-related carcinogenesis because E6 and E7 oncoproteins may impair p16 INK4a and, indirectly, bcl-2 functions. In this study, we analyzed the role of immunohistochemical expression of p16 INK4a and bcl-2 in HPV-infected cervical biopsies as prognostic markers of the progression of squamous intraepithelial lesion (SIL). Sixty-five cervical biopsies were stratified into two subgroups according to the second biopsy: 27 of them maintained a low-grade (LG)-SIL diagnosis, and 38 progressed from LG-SIL to high-grade (HG)-SIL. p16 INK4a and bcl-2 quantitative expression levels were measured by the immunoperoxidase method. PCR-DNA techniques were used to detect and type HPV. The Wilcoxon and Fisher exact tests were employed for the statistical analysis. In the group with an LG-SIL diagnosis at the second biopsy, no significant associations were found between p16 INK4a and bcl-2 expression and presence of HPV16/18. In the group that progressed to HG-SIL, a significant association was observed between p16 INK4a overexpression and HPV16/18 presence ( p=0.021), but none with bcl-2 levels. It is concluded that immunohistochemical bcl-2 expression may not be useful for predicting the progression of HPV-related SIL. In contrast, p16 INK4a overexpression seemed to be associated with HPV 16 and 18, suggesting that it may be a good marker for predicting SIL progression." @default.
• W2140989076 created "2016-06-24" @default.
• W2140989076 creator A5003740299 @default.
• W2140989076 creator A5005607316 @default.
• W2140989076 creator A5015685758 @default.
• W2140989076 creator A5066663413 @default.
• W2140989076 creator A5080077464 @default.
• W2140989076 creator A5081373252 @default.
• W2140989076 date "2005-04-01" @default.
• W2140989076 modified "2023-10-16" @default.
• W2140989076 title "Immunohistochemical Expression of p16^INK4a and bcl-2 According to HPV Type and to the Progression of Cervical Squamous Intraepithelial Lesions" @default.
• W2140989076 cites W1775480707 @default.
• W2140989076 cites W1963674032 @default.
• W2140989076 cites W1964628167 @default.
• W2140989076 cites W1973073454 @default.
• W2140989076 cites W1987350137 @default.
• W2140989076 cites W1992450511 @default.
• W2140989076 cites W1998218812 @default.
• W2140989076 cites W1998373889 @default.
• W2140989076 cites W2001586677 @default.
• W2140989076 cites W2008044691 @default.
• W2140989076 cites W2017689200 @default.
• W2140989076 cites W2022358833 @default.
• W2140989076 cites W2031328498 @default.
• W2140989076 cites W2040094987 @default.
• W2140989076 cites W2046577405 @default.
• W2140989076 cites W2048983937 @default.
• W2140989076 cites W2051731996 @default.
• W2140989076 cites W2057257609 @default.
• W2140989076 cites W2060786724 @default.
• W2140989076 cites W2067636502 @default.
• W2140989076 cites W2070152626 @default.
• W2140989076 cites W2073439462 @default.
• W2140989076 cites W2074166140 @default.
• W2140989076 cites W2077139988 @default.
• W2140989076 cites W2077218089 @default.
• W2140989076 cites W2089367279 @default.
• W2140989076 cites W2089695388 @default.
• W2140989076 cites W2094284771 @default.
• W2140989076 cites W2101809078 @default.
• W2140989076 cites W2112554468 @default.
• W2140989076 cites W2117775808 @default.
• W2140989076 cites W2140059211 @default.
• W2140989076 cites W2143019738 @default.
• W2140989076 cites W2170385036 @default.
• W2140989076 cites W2250036631 @default.
• W2140989076 cites W2268045557 @default.
• W2140989076 cites W2335723546 @default.
• W2140989076 cites W2485235476 @default.
• W2140989076 cites W4248096216 @default.
• W2140989076 cites W4251542078 @default.
• W2140989076 doi "https://doi.org/10.1369/jhc.4a6312.2005" @default.
• W2140989076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15805425" @default.
• W2140989076 hasPublicationYear "2005" @default.
• W2140989076 type Work @default.
• W2140989076 sameAs 2140989076 @default.
• W2140989076 citedByCount "38" @default.
• W2140989076 countsByYear W21409890762012 @default.
• W2140989076 countsByYear W21409890762013 @default.
• W2140989076 countsByYear W21409890762018 @default.
• W2140989076 countsByYear W21409890762020 @default.
• W2140989076 countsByYear W21409890762021 @default.
• W2140989076 crossrefType "journal-article" @default.
• W2140989076 hasAuthorship W2140989076A5003740299 @default.
• W2140989076 hasAuthorship W2140989076A5005607316 @default.
• W2140989076 hasAuthorship W2140989076A5015685758 @default.
• W2140989076 hasAuthorship W2140989076A5066663413 @default.
• W2140989076 hasAuthorship W2140989076A5080077464 @default.
• W2140989076 hasAuthorship W2140989076A5081373252 @default.
• W2140989076 hasBestOaLocation W21409890761 @default.
• W2140989076 hasConcept C121608353 @default.
• W2140989076 hasConcept C126322002 @default.
• W2140989076 hasConcept C128102431 @default.
• W2140989076 hasConcept C138055712 @default.
• W2140989076 hasConcept C142724271 @default.
• W2140989076 hasConcept C159654299 @default.
• W2140989076 hasConcept C203014093 @default.
• W2140989076 hasConcept C204232928 @default.
• W2140989076 hasConcept C2775924586 @default.
• W2140989076 hasConcept C2775934546 @default.
• W2140989076 hasConcept C2777343196 @default.
• W2140989076 hasConcept C2778220009 @default.
• W2140989076 hasConcept C502942594 @default.
• W2140989076 hasConcept C542903549 @default.
• W2140989076 hasConcept C555283112 @default.
• W2140989076 hasConcept C71924100 @default.
• W2140989076 hasConcept C86803240 @default.
• W2140989076 hasConceptScore W2140989076C121608353 @default.
• W2140989076 hasConceptScore W2140989076C126322002 @default.
• W2140989076 hasConceptScore W2140989076C128102431 @default.
• W2140989076 hasConceptScore W2140989076C138055712 @default.
• W2140989076 hasConceptScore W2140989076C142724271 @default.
• W2140989076 hasConceptScore W2140989076C159654299 @default.
• W2140989076 hasConceptScore W2140989076C203014093 @default.
• W2140989076 hasConceptScore W2140989076C204232928 @default.
• W2140989076 hasConceptScore W2140989076C2775924586 @default.
• W2140989076 hasConceptScore W2140989076C2775934546 @default.
• W2140989076 hasConceptScore W2140989076C2777343196 @default.

• next