Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140997669> ?p ?o ?g. }
- W2140997669 endingPage "82" @default.
- W2140997669 startingPage "69" @default.
- W2140997669 abstract "Adult stem cells reside in a specialized microenvironment, the niche, which controls their behavior. As mammary stem cells, and consequently their niches, are still poorly defined, we look at better-characterized adult mammalian stem cell niches in the hematopoietic system and the skin. We attempt to define the mammary stem cell niche functionally, based on the widely used mammary fat pad reconstitution assay. We note that the concept of the niche needs to be extended from the specialized microenvironment described in the hematopoietic system, to a model that takes into account the macroenviroment, as recently shown in the skin, and systemic clues as we will illustrate for the mammary gland where the reproductive hormones are major determinants of stem cell activation. In fact, in the mammary gland a special type of stem cells is determined only during pregnancy. Reproductive hormones act on hormone receptor positive cells, sensor cells, in the mammary epithelium to induce paracrine signaling that leads to activation of stem cells. Some of the downstream mediators are in common with other niches such as Wnt and possibly Notch signaling. Other signals are specific to the mammary gland such as amphiregulin and RANKL." @default.
- W2140997669 created "2016-06-24" @default.
- W2140997669 creator A5022693906 @default.
- W2140997669 creator A5074367632 @default.
- W2140997669 date "2008-10-31" @default.
- W2140997669 modified "2023-10-18" @default.
- W2140997669 title "What Signals Operate in the Mammary Niche?" @default.
- W2140997669 cites W134922517 @default.
- W2140997669 cites W1482923899 @default.
- W2140997669 cites W1494249446 @default.
- W2140997669 cites W1506807751 @default.
- W2140997669 cites W1523335221 @default.
- W2140997669 cites W1534987406 @default.
- W2140997669 cites W1579214734 @default.
- W2140997669 cites W1584810468 @default.
- W2140997669 cites W1600103888 @default.
- W2140997669 cites W1601214065 @default.
- W2140997669 cites W1645378787 @default.
- W2140997669 cites W1831282506 @default.
- W2140997669 cites W1835334395 @default.
- W2140997669 cites W1861988602 @default.
- W2140997669 cites W1864091535 @default.
- W2140997669 cites W1917059837 @default.
- W2140997669 cites W1965008951 @default.
- W2140997669 cites W1965562392 @default.
- W2140997669 cites W1970078194 @default.
- W2140997669 cites W1970291858 @default.
- W2140997669 cites W1975025595 @default.
- W2140997669 cites W1975718597 @default.
- W2140997669 cites W1976073214 @default.
- W2140997669 cites W1979041271 @default.
- W2140997669 cites W1979440527 @default.
- W2140997669 cites W1980332250 @default.
- W2140997669 cites W1980344438 @default.
- W2140997669 cites W1980867815 @default.
- W2140997669 cites W1981646920 @default.
- W2140997669 cites W1982603620 @default.
- W2140997669 cites W1985597947 @default.
- W2140997669 cites W1988372557 @default.
- W2140997669 cites W1988654710 @default.
- W2140997669 cites W1989456936 @default.
- W2140997669 cites W1995311865 @default.
- W2140997669 cites W1995584874 @default.
- W2140997669 cites W1995612509 @default.
- W2140997669 cites W1997387647 @default.
- W2140997669 cites W1997716402 @default.
- W2140997669 cites W2003787418 @default.
- W2140997669 cites W2006472255 @default.
- W2140997669 cites W2007341120 @default.
- W2140997669 cites W2009684443 @default.
- W2140997669 cites W2010807493 @default.
- W2140997669 cites W2010867675 @default.
- W2140997669 cites W2011202983 @default.
- W2140997669 cites W2011612270 @default.
- W2140997669 cites W2011842366 @default.
- W2140997669 cites W2015555645 @default.
- W2140997669 cites W2015974087 @default.
- W2140997669 cites W2016999459 @default.
- W2140997669 cites W2017625115 @default.
- W2140997669 cites W2017719081 @default.
- W2140997669 cites W2017802236 @default.
- W2140997669 cites W2021276131 @default.
- W2140997669 cites W2023332224 @default.
- W2140997669 cites W2023739654 @default.
- W2140997669 cites W2026897875 @default.
- W2140997669 cites W2028256918 @default.
- W2140997669 cites W2036638605 @default.
- W2140997669 cites W2039971323 @default.
- W2140997669 cites W2042508135 @default.
- W2140997669 cites W2042619286 @default.
- W2140997669 cites W2045066549 @default.
- W2140997669 cites W2048838448 @default.
- W2140997669 cites W2050084759 @default.
- W2140997669 cites W2050222325 @default.
- W2140997669 cites W2051433490 @default.
- W2140997669 cites W2051570103 @default.
- W2140997669 cites W2055755414 @default.
- W2140997669 cites W2055824128 @default.
- W2140997669 cites W2059694060 @default.
- W2140997669 cites W2059754354 @default.
- W2140997669 cites W2060610551 @default.
- W2140997669 cites W2066277278 @default.
- W2140997669 cites W2066843177 @default.
- W2140997669 cites W2068104926 @default.
- W2140997669 cites W2070386387 @default.
- W2140997669 cites W2070604157 @default.
- W2140997669 cites W2070793750 @default.
- W2140997669 cites W2072923149 @default.
- W2140997669 cites W2075587654 @default.
- W2140997669 cites W2076234955 @default.
- W2140997669 cites W2077123765 @default.
- W2140997669 cites W2079309583 @default.
- W2140997669 cites W2079370988 @default.
- W2140997669 cites W2082292567 @default.
- W2140997669 cites W2086258960 @default.
- W2140997669 cites W2090985333 @default.
- W2140997669 cites W2091005988 @default.
- W2140997669 cites W2093264452 @default.