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• W2140999711 startingPage "F540" @default.
• W2140999711 abstract "The expansion of cysts in polycystic kidneys bears several similarities to the invasion of the extracellular matrix by benign tumors. We therefore hypothesized that cyst-lining epithelial cells produce extracellular matrix-degrading metalloproteinases and that the inhibition of these enzymes may represent a potential target for therapeutic intervention. Using in situ hybridization, we first analyzed the expression of membrane-type metalloproteinase 1 (MMP-14), an essential matrix metalloproteinase, of its inhibitor TIMP-2, and of the cytokine transforming growth factor (TGF)-beta2 in the (cy/+) rat model of autosomal-dominant polycystic kidney disease. Upregulated MMP-14 mRNA was predominantly located in cyst-lining epithelia and distal tubules, whereas TIMP-2 mRNA was confined almost exclusively to fibroblasts. TGF-beta2, a cytokine known to regulate the expression of matrix metalloproteinases and their inhibitors, was also expressed by cyst wall epithelia. We then treated (cy/+) rats with the metalloproteinase inhibitor batimastat for a period of 8 wk. The treatment with the metalloproteinase inhibitor batimastat resulted in a significant reduction of cyst number and kidney weight. Our study suggests that metalloproteinase inhibitors represent a new therapeutic tool against polycystic kidney disease, which should be applicable independently of the background of the disease." @default.
• W2140999711 created "2016-06-24" @default.
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• W2140999711 date "2001-03-01" @default.
• W2140999711 modified "2023-10-15" @default.
• W2140999711 title "A possible role for metalloproteinases in renal cyst development" @default.
• W2140999711 cites W1510586846 @default.
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• W2140999711 cites W1551136355 @default.
• W2140999711 cites W1745661527 @default.
• W2140999711 cites W1935587632 @default.
• W2140999711 cites W1963776352 @default.
• W2140999711 cites W1966120295 @default.
• W2140999711 cites W1968084778 @default.
• W2140999711 cites W1969350781 @default.
• W2140999711 cites W1970269626 @default.
• W2140999711 cites W1971737996 @default.
• W2140999711 cites W1971890724 @default.
• W2140999711 cites W1977127210 @default.
• W2140999711 cites W1978309686 @default.
• W2140999711 cites W1986206023 @default.
• W2140999711 cites W1986701078 @default.
• W2140999711 cites W1988192546 @default.
• W2140999711 cites W1989546830 @default.
• W2140999711 cites W1992043741 @default.
• W2140999711 cites W1996541490 @default.
• W2140999711 cites W2005026678 @default.
• W2140999711 cites W2011961128 @default.
• W2140999711 cites W2012159432 @default.
• W2140999711 cites W2015750383 @default.
• W2140999711 cites W2016411107 @default.
• W2140999711 cites W2016484384 @default.
• W2140999711 cites W2019869046 @default.
• W2140999711 cites W2020479491 @default.
• W2140999711 cites W2021859728 @default.
• W2140999711 cites W2028097749 @default.
• W2140999711 cites W2032209601 @default.
• W2140999711 cites W2035034837 @default.
• W2140999711 cites W2035410475 @default.
• W2140999711 cites W2035838858 @default.
• W2140999711 cites W2036077644 @default.
• W2140999711 cites W2039232401 @default.
• W2140999711 cites W2041488230 @default.
• W2140999711 cites W2047825570 @default.
• W2140999711 cites W2048441028 @default.
• W2140999711 cites W2051042325 @default.
• W2140999711 cites W2053002899 @default.
• W2140999711 cites W2057686759 @default.
• W2140999711 cites W2059659414 @default.
• W2140999711 cites W2075165951 @default.
• W2140999711 cites W2078819077 @default.
• W2140999711 cites W2081451346 @default.
• W2140999711 cites W2085260843 @default.
• W2140999711 cites W2086237781 @default.
• W2140999711 cites W2087077483 @default.
• W2140999711 cites W2093986262 @default.
• W2140999711 cites W2095573055 @default.
• W2140999711 cites W2101314011 @default.
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• W2140999711 cites W2118523009 @default.
• W2140999711 cites W2132018948 @default.
• W2140999711 cites W2132091954 @default.
• W2140999711 cites W2134477837 @default.
• W2140999711 cites W2147660741 @default.
• W2140999711 cites W2152294869 @default.
• W2140999711 cites W2157415385 @default.
• W2140999711 cites W2178934203 @default.
• W2140999711 cites W2182848575 @default.
• W2140999711 cites W2248836849 @default.
• W2140999711 cites W2257686840 @default.
• W2140999711 cites W2283610042 @default.
• W2140999711 cites W2298627547 @default.
• W2140999711 cites W2306558186 @default.
• W2140999711 cites W2335187016 @default.
• W2140999711 cites W2340647148 @default.
• W2140999711 cites W2401280416 @default.
• W2140999711 cites W3151254939 @default.
• W2140999711 cites W4230053059 @default.
• W2140999711 cites W4232995978 @default.
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• W2140999711 cites W4294216491 @default.
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• W2140999711 doi "https://doi.org/10.1152/ajprenal.2001.280.3.f540" @default.
• W2140999711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11181417" @default.
• W2140999711 hasPublicationYear "2001" @default.
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