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- W2141004834 abstract "Introduction : Add-on treatment with azithromycin reduces the rate of exacerbations and lower respiratory tract infections (LTRI) in specific phenotypes of severe asthma. High resolution CT (HRCT) determined air-trapping in asthmatic subjects identifies a group of individuals with a high risk of severe disease. Objectives : Can HRCT determined air-trapping predict clinical outcome of add-on treatment with azithromycin in severe asthmatics? Methods : 68 subjects with exacerbation prone severe asthma were randomized to placebo (n=32) or azithromycin (n=36) as add-on treatment to combination therapy of inhaled corticosteroids and long-acting β2 agonists. Two subgroups were defined according to the presence (n=43) or absence (n=25) of air-trapping on HRCT. The primary clinical outcome (PEP) is the rate of patients with severe exacerbations and LRTI requiring treatment with antibiotics during the 26-week treatment phase. Results : In the patient group without air-trapping on HRCT, there was a 26% absolute reduction in PEP rate (66% PEP rate in the intervention group with placebo and 40% PEP rate in the intervention group with azithromycin). In the patient group with HRCT determined air-trapping, PEP rates showed no benefit from azithromycin (42% PEP rate in the intervention group with placebo and 56% PEP rate in the intervention group with azithromycin). Conclusion : These data suggest a higher clinical response of add-on treatment with azithromycin in exacerbation prone severe asthma without air-trapping on high resolution CT." @default.
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- W2141004834 date "2014-09-01" @default.
- W2141004834 modified "2023-09-27" @default.
- W2141004834 title "Air-trapping on HRCT as a marker for patient outcome in severe asthmatics treated with azithromycin" @default.
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