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• W2141006000 abstract "The k-turn is a widespread structural motif that introduces a tight kink into the helical axis of double-stranded RNA. The adenine bases of consecutive G•A pairs are directed toward the minor groove of the opposing helix, hydrogen bonding in a typical A-minor interaction. We show here that the available structures of k-turns divide into two classes, depending on whether N3 or N1 of the adenine at the 2b position accepts a hydrogen bond from the O2' at the -1n position. There is a coordinated structural change involving a number of hydrogen bonds between the two classes. We show here that Kt-7 can adopt either the N3 or N1 structures depending on environment. While it has the N1 structure in the ribosome, on engineering it into the SAM-I riboswitch, it changes to the N3 structure, resulting in a significant alteration in the trajectory of the helical arms." @default.
• W2141006000 created "2016-06-24" @default.
• W2141006000 creator A5048464493 @default.
• W2141006000 creator A5054701391 @default.
• W2141006000 date "2013-01-16" @default.
• W2141006000 modified "2023-10-16" @default.
• W2141006000 title "The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment" @default.
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• W2141006000 doi "https://doi.org/10.1261/rna.036657.112" @default.
• W2141006000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3677246" @default.
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