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• W2141014609 abstract "Abstract Skin infections caused by Staphylococcus aureus are a major clinical concern, especially if they are caused by multi‐resistant strains. In these cases, a spread into deeper soft tissues or the bloodstream results in life‐threatening conditions that are difficult to treat by conventional antibiotics. Previous in vitro experiments with a small β‐lactone‐based molecule demonstrated that antibiotic‐sensitive and ‐resistant S. aureus strains are effectively disarmed in their virulence and corresponding pathogenicity. In this work, in vivo mouse studies show that this methodology is effective for the treatment of skin abscesses in mice. A single dose of the β‐lactone significantly decreased abscess size even when applied 6 h post‐infection. Although the molecule requires pharmacological optimization (improved stability, for example), this study emphasizes the potential value of antivirulence therapies." @default.
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• W2141014609 date "2014-02-20" @default.
• W2141014609 modified "2023-10-16" @default.
• W2141014609 title "A β-Lactone-Based Antivirulence Drug Ameliorates<i>Staphylococcus aureus</i>Skin Infections in Mice" @default.
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• W2141014609 doi "https://doi.org/10.1002/cmdc.201300325" @default.
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