Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141020397> ?p ?o ?g. }
- W2141020397 endingPage "345" @default.
- W2141020397 startingPage "339" @default.
- W2141020397 abstract "The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn’s disease represents an important step towards the delineation of the immunopathogenesis of inflammatory bowel disease. CARD15 functions as an intracellular receptor for bacterial components and thus represents an important link between inflammatory bowel disease and innate immunity. Three major CARD15/NOD2 gene mutations have been associated with Crohn’s disease in Caucasians in several independent studies. Together, they explain about 20% of the genetic susceptibility for Crohn’s disease. Genotype-phenotype analyses demonstrated an association of these mutations with ileum-specific disease, an increased incidence of the fibrostenotic phenotype and an earlier age of disease onset. Beside these associations, no other relationship between the CARD15/NOD2 genotype and disease behavior or response to treatment has been detailed so far. Thus, the clinical impact of knowing the patient’s genotype is limited at this time. Screening for CARD15 mutations in order to identify high-risk individuals or to introduce an individualized disease management is therefore currently not recommended." @default.
- W2141020397 created "2016-06-24" @default.
- W2141020397 creator A5021068026 @default.
- W2141020397 creator A5029588952 @default.
- W2141020397 creator A5048030193 @default.
- W2141020397 creator A5086525751 @default.
- W2141020397 date "2003-01-01" @default.
- W2141020397 modified "2023-09-26" @default.
- W2141020397 title "Alterations of the CARD15/NOD2 Gene and the Impact on Management and Treatment of Crohn’s Disease Patients" @default.
- W2141020397 cites W159720762 @default.
- W2141020397 cites W1642457845 @default.
- W2141020397 cites W1670573097 @default.
- W2141020397 cites W1970571999 @default.
- W2141020397 cites W1978391665 @default.
- W2141020397 cites W1988086493 @default.
- W2141020397 cites W1988183776 @default.
- W2141020397 cites W1989303754 @default.
- W2141020397 cites W1998395322 @default.
- W2141020397 cites W2003784229 @default.
- W2141020397 cites W2005272937 @default.
- W2141020397 cites W2018518908 @default.
- W2141020397 cites W2021706207 @default.
- W2141020397 cites W2026592131 @default.
- W2141020397 cites W2041954909 @default.
- W2141020397 cites W2052127995 @default.
- W2141020397 cites W2064027072 @default.
- W2141020397 cites W2068233027 @default.
- W2141020397 cites W2072229986 @default.
- W2141020397 cites W2073375483 @default.
- W2141020397 cites W2075583035 @default.
- W2141020397 cites W2086607027 @default.
- W2141020397 cites W2096215604 @default.
- W2141020397 cites W2111900042 @default.
- W2141020397 cites W2117974617 @default.
- W2141020397 cites W2126358235 @default.
- W2141020397 cites W2148870886 @default.
- W2141020397 cites W2148930908 @default.
- W2141020397 cites W2152532561 @default.
- W2141020397 cites W2156440664 @default.
- W2141020397 cites W2158507534 @default.
- W2141020397 cites W2158859561 @default.
- W2141020397 cites W2160855953 @default.
- W2141020397 cites W2183869328 @default.
- W2141020397 cites W4229850346 @default.
- W2141020397 cites W4231022815 @default.
- W2141020397 cites W4241023869 @default.
- W2141020397 cites W4248589246 @default.
- W2141020397 cites W4253480665 @default.
- W2141020397 doi "https://doi.org/10.1159/000075357" @default.
- W2141020397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14752224" @default.
- W2141020397 hasPublicationYear "2003" @default.
- W2141020397 type Work @default.
- W2141020397 sameAs 2141020397 @default.
- W2141020397 citedByCount "23" @default.
- W2141020397 countsByYear W21410203972012 @default.
- W2141020397 countsByYear W21410203972013 @default.
- W2141020397 crossrefType "journal-article" @default.
- W2141020397 hasAuthorship W2141020397A5021068026 @default.
- W2141020397 hasAuthorship W2141020397A5029588952 @default.
- W2141020397 hasAuthorship W2141020397A5048030193 @default.
- W2141020397 hasAuthorship W2141020397A5086525751 @default.
- W2141020397 hasBestOaLocation W21410203972 @default.
- W2141020397 hasConcept C104317684 @default.
- W2141020397 hasConcept C126322002 @default.
- W2141020397 hasConcept C127716648 @default.
- W2141020397 hasConcept C135763542 @default.
- W2141020397 hasConcept C203014093 @default.
- W2141020397 hasConcept C2778260677 @default.
- W2141020397 hasConcept C2779134260 @default.
- W2141020397 hasConcept C2779280984 @default.
- W2141020397 hasConcept C54355233 @default.
- W2141020397 hasConcept C71924100 @default.
- W2141020397 hasConcept C7573103 @default.
- W2141020397 hasConcept C86803240 @default.
- W2141020397 hasConceptScore W2141020397C104317684 @default.
- W2141020397 hasConceptScore W2141020397C126322002 @default.
- W2141020397 hasConceptScore W2141020397C127716648 @default.
- W2141020397 hasConceptScore W2141020397C135763542 @default.
- W2141020397 hasConceptScore W2141020397C203014093 @default.
- W2141020397 hasConceptScore W2141020397C2778260677 @default.
- W2141020397 hasConceptScore W2141020397C2779134260 @default.
- W2141020397 hasConceptScore W2141020397C2779280984 @default.
- W2141020397 hasConceptScore W2141020397C54355233 @default.
- W2141020397 hasConceptScore W2141020397C71924100 @default.
- W2141020397 hasConceptScore W2141020397C7573103 @default.
- W2141020397 hasConceptScore W2141020397C86803240 @default.
- W2141020397 hasIssue "4" @default.
- W2141020397 hasLocation W21410203971 @default.
- W2141020397 hasLocation W21410203972 @default.
- W2141020397 hasLocation W21410203973 @default.
- W2141020397 hasOpenAccess W2141020397 @default.
- W2141020397 hasPrimaryLocation W21410203971 @default.
- W2141020397 hasRelatedWork W1618585600 @default.
- W2141020397 hasRelatedWork W1997516129 @default.
- W2141020397 hasRelatedWork W2019729721 @default.
- W2141020397 hasRelatedWork W2093775554 @default.
- W2141020397 hasRelatedWork W2141020397 @default.
- W2141020397 hasRelatedWork W2156440664 @default.