Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141036167> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2141036167 endingPage "70" @default.
- W2141036167 startingPage "59" @default.
- W2141036167 abstract "The specificity of the interaction between the combining site (paratope) of an antibody molecule and an antigenic determinant (epitope) is a concept originated from the first immunochemical studies conducted at the beginning of the century by von Behring and Arrhenius [ 11. This concept is a paradigm for all theories aimed at explaining the function of the immune system [2,3]. X-ray crystallographic studies of the association between an antibody molecule and an antigenic determinant allowed a molecular approach of the understanding of this interaction. These studies showed that only a few contacting residues borne by the hypervariable regions of the V regions interact with the functional groups of the epitope [4]. These studies determined that the binding of a hapten to an antibody is based on a structural complementarity with minimal structural adaptation, since only a few residues of the hypervariable region and a few functional groups of the antigen are involved in antigen-antibody interactions. It was believed from these experiments that each antibody would be specific for a single possible antigen. However, there are studies showing that antibodies can bind to several non cross-reactive antigens [5]. These studies followed the development of the hybridoma technology since the availability of monoclonal antibodies provided tools to determine the binding of the same paratope to several antigenic determinants. Examples of multi-specificity" @default.
- W2141036167 created "2016-06-24" @default.
- W2141036167 creator A5010209734 @default.
- W2141036167 creator A5048005287 @default.
- W2141036167 date "1988-01-01" @default.
- W2141036167 modified "2023-10-16" @default.
- W2141036167 title "Antibodies Possessing Multiple Antigen Specificities and Exhibiting Extensive Idiotypic Cross-reactivity" @default.
- W2141036167 cites W1948820288 @default.
- W2141036167 cites W1971427460 @default.
- W2141036167 cites W1974489930 @default.
- W2141036167 cites W1975868741 @default.
- W2141036167 cites W1980238349 @default.
- W2141036167 cites W1981789648 @default.
- W2141036167 cites W2016190951 @default.
- W2141036167 cites W2017061571 @default.
- W2141036167 cites W2032993279 @default.
- W2141036167 cites W2034515513 @default.
- W2141036167 cites W2044485561 @default.
- W2141036167 cites W2056444958 @default.
- W2141036167 cites W2077644752 @default.
- W2141036167 cites W2081599044 @default.
- W2141036167 cites W2082901195 @default.
- W2141036167 cites W2083147566 @default.
- W2141036167 cites W2103601503 @default.
- W2141036167 cites W2118164586 @default.
- W2141036167 cites W2120513063 @default.
- W2141036167 cites W2128587758 @default.
- W2141036167 cites W2142316029 @default.
- W2141036167 cites W4211183651 @default.
- W2141036167 doi "https://doi.org/10.3109/08830188809051182" @default.
- W2141036167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2469751" @default.
- W2141036167 hasPublicationYear "1988" @default.
- W2141036167 type Work @default.
- W2141036167 sameAs 2141036167 @default.
- W2141036167 citedByCount "6" @default.
- W2141036167 countsByYear W21410361672019 @default.
- W2141036167 crossrefType "journal-article" @default.
- W2141036167 hasAuthorship W2141036167A5010209734 @default.
- W2141036167 hasAuthorship W2141036167A5048005287 @default.
- W2141036167 hasConcept C147483822 @default.
- W2141036167 hasConcept C159047783 @default.
- W2141036167 hasConcept C159654299 @default.
- W2141036167 hasConcept C203014093 @default.
- W2141036167 hasConcept C2779142602 @default.
- W2141036167 hasConcept C3020064264 @default.
- W2141036167 hasConcept C542903549 @default.
- W2141036167 hasConcept C74505204 @default.
- W2141036167 hasConcept C86803240 @default.
- W2141036167 hasConceptScore W2141036167C147483822 @default.
- W2141036167 hasConceptScore W2141036167C159047783 @default.
- W2141036167 hasConceptScore W2141036167C159654299 @default.
- W2141036167 hasConceptScore W2141036167C203014093 @default.
- W2141036167 hasConceptScore W2141036167C2779142602 @default.
- W2141036167 hasConceptScore W2141036167C3020064264 @default.
- W2141036167 hasConceptScore W2141036167C542903549 @default.
- W2141036167 hasConceptScore W2141036167C74505204 @default.
- W2141036167 hasConceptScore W2141036167C86803240 @default.
- W2141036167 hasIssue "1-2" @default.
- W2141036167 hasLocation W21410361671 @default.
- W2141036167 hasLocation W21410361672 @default.
- W2141036167 hasOpenAccess W2141036167 @default.
- W2141036167 hasPrimaryLocation W21410361671 @default.
- W2141036167 hasRelatedWork W1981602403 @default.
- W2141036167 hasRelatedWork W2007211857 @default.
- W2141036167 hasRelatedWork W2016002738 @default.
- W2141036167 hasRelatedWork W2029199363 @default.
- W2141036167 hasRelatedWork W2032136729 @default.
- W2141036167 hasRelatedWork W2135677272 @default.
- W2141036167 hasRelatedWork W2178175538 @default.
- W2141036167 hasRelatedWork W2413382531 @default.
- W2141036167 hasRelatedWork W4236931100 @default.
- W2141036167 hasRelatedWork W2574914054 @default.
- W2141036167 hasVolume "3" @default.
- W2141036167 isParatext "false" @default.
- W2141036167 isRetracted "false" @default.
- W2141036167 magId "2141036167" @default.
- W2141036167 workType "article" @default.