FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141071177> ?p ?o ?g. }

• W2141071177 endingPage "4642" @default.
• W2141071177 startingPage "4631" @default.
• W2141071177 abstract "Enterohemorrhagic Escherichia coli (EHEC), a subgroup of Shiga toxin (Stx)-producing E. coli (STEC), is a leading cause of diarrhea and hemolytic-uremic syndrome (HUS) in humans. However, urinary tract infections (UTIs) caused by this microorganism but not associated with diarrhea have occasionally been reported. We geno- and phenotypically characterized three EHEC isolates obtained from the urine of hospitalized patients suffering from UTIs. These isolates carried typical EHEC virulence markers and belonged to HUS-associated E. coli (HUSEC) clones, but they lacked virulence markers typical of uropathogenic E. coli. One isolate exhibited a localized adherence (LA)-like pattern on T24 urinary bladder epithelial cells. Since the glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer) are well-known receptors for Stx but also for P fimbriae, a major virulence factor of extraintestinal pathogenic E. coli (ExPEC), the expression of Gb3Cer and Gb4Cer by T24 cells and in murine urinary bladder tissue was examined by thin-layer chromatography and mass spectrometry. We provide data indicating that Stxs released by the EHEC isolates bind to Gb3Cer and Gb4Cer isolated from T24 cells, which were susceptible to Stx. All three EHEC isolates expressed stx genes upon growth in urine. Two strains were able to cause UTI in a murine infection model and could not be outcompeted in urine in vitro by typical uropathogenic E. coli isolates. Our results indicate that despite the lack of ExPEC virulence markers, EHEC variants may exhibit in certain suitable hosts, e.g., in hospital patients, a uropathogenic potential. The contribution of EHEC virulence factors to uropathogenesis remains to be further investigated." @default.
• W2141071177 created "2016-06-24" @default.
• W2141071177 creator A5030317221 @default.
• W2141071177 creator A5037678266 @default.
• W2141071177 creator A5042689984 @default.
• W2141071177 creator A5044205264 @default.
• W2141071177 creator A5055260011 @default.
• W2141071177 creator A5055687968 @default.
• W2141071177 creator A5071568778 @default.
• W2141071177 creator A5079061786 @default.
• W2141071177 creator A5079876768 @default.
• W2141071177 creator A5083103531 @default.
• W2141071177 creator A5088124868 @default.
• W2141071177 date "2014-11-01" @default.
• W2141071177 modified "2023-10-06" @default.
• W2141071177 title "Characterization of Urinary Tract Infection-Associated Shiga Toxin-Producing Escherichia coli" @default.
• W2141071177 cites W1571620179 @default.
• W2141071177 cites W1641182372 @default.
• W2141071177 cites W1821376019 @default.
• W2141071177 cites W1926429676 @default.
• W2141071177 cites W1937263947 @default.
• W2141071177 cites W1956725963 @default.
• W2141071177 cites W1964723513 @default.
• W2141071177 cites W1966597734 @default.
• W2141071177 cites W1969209152 @default.
• W2141071177 cites W1971879854 @default.
• W2141071177 cites W1972651280 @default.
• W2141071177 cites W1981942372 @default.
• W2141071177 cites W1985783302 @default.
• W2141071177 cites W1988516580 @default.
• W2141071177 cites W1989938301 @default.
• W2141071177 cites W1996719637 @default.
• W2141071177 cites W1999823179 @default.
• W2141071177 cites W2004888237 @default.
• W2141071177 cites W2008649826 @default.
• W2141071177 cites W2014534296 @default.
• W2141071177 cites W2021398192 @default.
• W2141071177 cites W2025352881 @default.
• W2141071177 cites W2028585341 @default.
• W2141071177 cites W2029958737 @default.
• W2141071177 cites W2031981444 @default.
• W2141071177 cites W2034733856 @default.
• W2141071177 cites W2036860224 @default.
• W2141071177 cites W2051567318 @default.
• W2141071177 cites W2057295574 @default.
• W2141071177 cites W2079711514 @default.
• W2141071177 cites W2080681701 @default.
• W2141071177 cites W2081143709 @default.
• W2141071177 cites W2081240544 @default.
• W2141071177 cites W2085397554 @default.
• W2141071177 cites W2090241807 @default.
• W2141071177 cites W2090732181 @default.
• W2141071177 cites W2093941883 @default.
• W2141071177 cites W2095624395 @default.
• W2141071177 cites W2105300608 @default.
• W2141071177 cites W2107057345 @default.
• W2141071177 cites W2122949601 @default.
• W2141071177 cites W2125774503 @default.
• W2141071177 cites W2128115968 @default.
• W2141071177 cites W2128139814 @default.
• W2141071177 cites W2128629257 @default.
• W2141071177 cites W2129679668 @default.
• W2141071177 cites W2130749080 @default.
• W2141071177 cites W2132756279 @default.
• W2141071177 cites W2134011061 @default.
• W2141071177 cites W2134973504 @default.
• W2141071177 cites W2138139644 @default.
• W2141071177 cites W2138738692 @default.
• W2141071177 cites W2139208282 @default.
• W2141071177 cites W2140167904 @default.
• W2141071177 cites W2141292721 @default.
• W2141071177 cites W2144498842 @default.
• W2141071177 cites W2146297863 @default.
• W2141071177 cites W2148440676 @default.
• W2141071177 cites W2150262463 @default.
• W2141071177 cites W2157973184 @default.
• W2141071177 cites W2161186278 @default.
• W2141071177 cites W2164097967 @default.
• W2141071177 cites W2168910407 @default.
• W2141071177 cites W2171745921 @default.
• W2141071177 cites W2328237709 @default.
• W2141071177 cites W2333184413 @default.
• W2141071177 cites W4246466855 @default.
• W2141071177 doi "https://doi.org/10.1128/iai.01701-14" @default.
• W2141071177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4249321" @default.
• W2141071177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25156739" @default.
• W2141071177 hasPublicationYear "2014" @default.
• W2141071177 type Work @default.
• W2141071177 sameAs 2141071177 @default.
• W2141071177 citedByCount "23" @default.
• W2141071177 countsByYear W21410711772015 @default.
• W2141071177 countsByYear W21410711772016 @default.
• W2141071177 countsByYear W21410711772018 @default.
• W2141071177 countsByYear W21410711772019 @default.
• W2141071177 countsByYear W21410711772020 @default.
• W2141071177 countsByYear W21410711772022 @default.
• W2141071177 countsByYear W21410711772023 @default.
• W2141071177 crossrefType "journal-article" @default.

• next