Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141087445> ?p ?o ?g. }
- W2141087445 abstract "Streptococcus pneumoniae strains lacking capsular polysaccharide have been increasingly reported in carriage and disease contexts. Since most cases of otitis media involve more than one bacterial species, we aimed to determine the capacity of a nonencapsulated S. pneumoniae clinical isolate to induce disease in the context of a single-species infection and as a polymicrobial infection with nontypeable Haemophilus influenzae. Using the chinchilla model of otitis media, we found that nonencapsulated S. pneumoniae colonizes the nasopharynx following intranasal inoculation, but does not readily ascend into the middle ear. However, when we inoculated nonencapsulated S. pneumoniae directly into the middle ear, the bacteria persisted for two weeks post-inoculation and induced symptoms consistent with chronic otitis media. During coinfection with nontypeable H. influenzae, both species persisted for one week and induced polymicrobial otitis media. We also observed that nontypeable H. influenzae conferred passive protection from killing by amoxicillin upon S. pneumoniae from within polymicrobial biofilms in vitro. Therefore, based on these results, we conclude that nonencapsulated pneumococci are a potential causative agent of chronic/recurrent otitis media, and can also cause mutualistic infection with other opportunists, which could complicate treatment outcomes." @default.
- W2141087445 created "2016-06-24" @default.
- W2141087445 creator A5019756614 @default.
- W2141087445 creator A5020340236 @default.
- W2141087445 creator A5033448658 @default.
- W2141087445 creator A5051727723 @default.
- W2141087445 creator A5057325006 @default.
- W2141087445 creator A5059579482 @default.
- W2141087445 creator A5073145945 @default.
- W2141087445 creator A5082367545 @default.
- W2141087445 date "2014-12-04" @default.
- W2141087445 modified "2023-09-25" @default.
- W2141087445 title "Nonencapsulated Streptococcus pneumoniae causes otitis media during single-species infection and during polymicrobial infection with nontypeable Haemophilus influenzae" @default.
- W2141087445 cites W1643130021 @default.
- W2141087445 cites W1676539675 @default.
- W2141087445 cites W1865523903 @default.
- W2141087445 cites W1965837208 @default.
- W2141087445 cites W1976083854 @default.
- W2141087445 cites W1976925323 @default.
- W2141087445 cites W2005650701 @default.
- W2141087445 cites W2011696576 @default.
- W2141087445 cites W2013365839 @default.
- W2141087445 cites W2013572910 @default.
- W2141087445 cites W2036082547 @default.
- W2141087445 cites W2050542389 @default.
- W2141087445 cites W2055912129 @default.
- W2141087445 cites W2070409252 @default.
- W2141087445 cites W2083880291 @default.
- W2141087445 cites W2086353714 @default.
- W2141087445 cites W2101243222 @default.
- W2141087445 cites W2101347921 @default.
- W2141087445 cites W2105131328 @default.
- W2141087445 cites W2106352015 @default.
- W2141087445 cites W2107069650 @default.
- W2141087445 cites W2111775856 @default.
- W2141087445 cites W2124324863 @default.
- W2141087445 cites W2127635852 @default.
- W2141087445 cites W2128742116 @default.
- W2141087445 cites W2133059828 @default.
- W2141087445 cites W2135789554 @default.
- W2141087445 cites W2143051636 @default.
- W2141087445 cites W2143490456 @default.
- W2141087445 cites W2145435157 @default.
- W2141087445 cites W2152897453 @default.
- W2141087445 cites W2156039065 @default.
- W2141087445 cites W2156659808 @default.
- W2141087445 cites W2157011273 @default.
- W2141087445 cites W2157173569 @default.
- W2141087445 cites W2157373727 @default.
- W2141087445 cites W2157999551 @default.
- W2141087445 cites W2163722428 @default.
- W2141087445 cites W2164873258 @default.
- W2141087445 cites W2166319786 @default.
- W2141087445 cites W2167840853 @default.
- W2141087445 cites W2169665937 @default.
- W2141087445 cites W2171226149 @default.
- W2141087445 cites W2571244510 @default.
- W2141087445 doi "https://doi.org/10.1093/femspd/ftu011" @default.
- W2141087445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4849347" @default.
- W2141087445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26014114" @default.
- W2141087445 hasPublicationYear "2014" @default.
- W2141087445 type Work @default.
- W2141087445 sameAs 2141087445 @default.
- W2141087445 citedByCount "24" @default.
- W2141087445 countsByYear W21410874452016 @default.
- W2141087445 countsByYear W21410874452017 @default.
- W2141087445 countsByYear W21410874452018 @default.
- W2141087445 countsByYear W21410874452019 @default.
- W2141087445 countsByYear W21410874452020 @default.
- W2141087445 countsByYear W21410874452021 @default.
- W2141087445 countsByYear W21410874452022 @default.
- W2141087445 crossrefType "journal-article" @default.
- W2141087445 hasAuthorship W2141087445A5019756614 @default.
- W2141087445 hasAuthorship W2141087445A5020340236 @default.
- W2141087445 hasAuthorship W2141087445A5033448658 @default.
- W2141087445 hasAuthorship W2141087445A5051727723 @default.
- W2141087445 hasAuthorship W2141087445A5057325006 @default.
- W2141087445 hasAuthorship W2141087445A5059579482 @default.
- W2141087445 hasAuthorship W2141087445A5073145945 @default.
- W2141087445 hasAuthorship W2141087445A5082367545 @default.
- W2141087445 hasBestOaLocation W21410874451 @default.
- W2141087445 hasConcept C105702510 @default.
- W2141087445 hasConcept C151730666 @default.
- W2141087445 hasConcept C203014093 @default.
- W2141087445 hasConcept C2522874641 @default.
- W2141087445 hasConcept C2776439223 @default.
- W2141087445 hasConcept C2776925733 @default.
- W2141087445 hasConcept C2777154767 @default.
- W2141087445 hasConcept C2777813720 @default.
- W2141087445 hasConcept C2777846895 @default.
- W2141087445 hasConcept C2779343474 @default.
- W2141087445 hasConcept C2781253189 @default.
- W2141087445 hasConcept C501593827 @default.
- W2141087445 hasConcept C54355233 @default.
- W2141087445 hasConcept C86803240 @default.
- W2141087445 hasConcept C89423630 @default.
- W2141087445 hasConceptScore W2141087445C105702510 @default.
- W2141087445 hasConceptScore W2141087445C151730666 @default.
- W2141087445 hasConceptScore W2141087445C203014093 @default.
- W2141087445 hasConceptScore W2141087445C2522874641 @default.