FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141089356> ?p ?o ?g. }

• W2141089356 endingPage "312" @default.
• W2141089356 startingPage "297" @default.
• W2141089356 abstract "Tuberculosis, a bacterial disease prevalent since ancient times, continues to cause the most deaths globally compared with all other diseases. The causative agent Mycobacterium tuberculosis is responsible for different types of tuberculosis in humans; however, pulmonary tuberculosis is the most common and causes the most deaths. Mycobacterium tuberculosis is an intracellular pathogenic bacterium, which has developed sophisticated mechanisms to survive inside host mononuclear phagocytes and thus evade the host immune system. This is attributed primarily to an inadequate immune response toward infecting bacteria, which results in temporary growth inhibition rather than death and subsequently allows the bacteria to multiply immensely, leading to full-blown disease in an individual. This disease has become a challenge due to poor diagnosis, a low-efficiency tuberculosis vaccine (Mycobacterium bovis Bacillus Calmette-Guerin [BCG]), a long-term antibacterial chemotherapy regimen (approximately 6 months), and an emergence of multiple drug resistant strains of Mycobacterium tuberculosis especially in people with human immune deficiency virus (HIV) infection, for whom researchers worldwide must develop effective short-term chemotherapy and an effective vaccine. In this review different aspects of vaccines in tuberculosis are discussed, and these include the traditional BCG vaccine, the modern auxotrophic vaccine, the subunit or acellular vaccine; and a DNA vaccine. We discuss also the potential of mycobacterial lipids as a vaccine or as an adjuvant in the future. Since complete genome information of Mycobacterium tuberculosis H37Rv and bioinformatics tools are available, it is possible to develop new strategies for a better and effective tuberculosis vaccine, which can replace the traditional BCG vaccine." @default.
• W2141089356 created "2016-06-24" @default.
• W2141089356 creator A5013773246 @default.
• W2141089356 creator A5017029216 @default.
• W2141089356 creator A5022559832 @default.
• W2141089356 creator A5051394027 @default.
• W2141089356 date "2003-01-01" @default.
• W2141089356 modified "2023-09-26" @default.
• W2141089356 title "How Far Have We Reached in Tuberculosis Vaccine Development?" @default.
• W2141089356 cites W1482834638 @default.
• W2141089356 cites W1508427423 @default.
• W2141089356 cites W1542256644 @default.
• W2141089356 cites W1573445204 @default.
• W2141089356 cites W1589948634 @default.
• W2141089356 cites W1592760947 @default.
• W2141089356 cites W1864461701 @default.
• W2141089356 cites W1897049302 @default.
• W2141089356 cites W1912825022 @default.
• W2141089356 cites W1953993731 @default.
• W2141089356 cites W1961207913 @default.
• W2141089356 cites W1964750168 @default.
• W2141089356 cites W1971391786 @default.
• W2141089356 cites W1988009316 @default.
• W2141089356 cites W1989533108 @default.
• W2141089356 cites W1990362910 @default.
• W2141089356 cites W1991466905 @default.
• W2141089356 cites W1992603564 @default.
• W2141089356 cites W1993417629 @default.
• W2141089356 cites W1995343720 @default.
• W2141089356 cites W2000056755 @default.
• W2141089356 cites W2007341608 @default.
• W2141089356 cites W2009630151 @default.
• W2141089356 cites W2022048079 @default.
• W2141089356 cites W2024624695 @default.
• W2141089356 cites W2027679419 @default.
• W2141089356 cites W2028504399 @default.
• W2141089356 cites W2032884254 @default.
• W2141089356 cites W2035953055 @default.
• W2141089356 cites W2040567629 @default.
• W2141089356 cites W2054393627 @default.
• W2141089356 cites W2054941139 @default.
• W2141089356 cites W2055211809 @default.
• W2141089356 cites W2056356579 @default.
• W2141089356 cites W2059169428 @default.
• W2141089356 cites W2059543044 @default.
• W2141089356 cites W2060098138 @default.
• W2141089356 cites W2062860313 @default.
• W2141089356 cites W2068777991 @default.
• W2141089356 cites W2072432037 @default.
• W2141089356 cites W2075477269 @default.
• W2141089356 cites W2079129173 @default.
• W2141089356 cites W2082738967 @default.
• W2141089356 cites W2090599143 @default.
• W2141089356 cites W2096196194 @default.
• W2141089356 cites W2097951029 @default.
• W2141089356 cites W2102004952 @default.
• W2141089356 cites W2103425201 @default.
• W2141089356 cites W2109352986 @default.
• W2141089356 cites W2110301209 @default.
• W2141089356 cites W2113981405 @default.
• W2141089356 cites W2116751080 @default.
• W2141089356 cites W2121135239 @default.
• W2141089356 cites W2121968955 @default.
• W2141089356 cites W2123643891 @default.
• W2141089356 cites W2124672930 @default.
• W2141089356 cites W2132657101 @default.
• W2141089356 cites W2139832445 @default.
• W2141089356 cites W2140981202 @default.
• W2141089356 cites W2149350146 @default.
• W2141089356 cites W2149737058 @default.
• W2141089356 cites W2151612737 @default.
• W2141089356 cites W2154578113 @default.
• W2141089356 cites W2154819564 @default.
• W2141089356 cites W2157559696 @default.
• W2141089356 cites W2157605618 @default.
• W2141089356 cites W2158023121 @default.
• W2141089356 cites W2158204548 @default.
• W2141089356 cites W2159377027 @default.
• W2141089356 cites W2166496548 @default.
• W2141089356 cites W2166582198 @default.
• W2141089356 cites W2168653518 @default.
• W2141089356 cites W2413589002 @default.
• W2141089356 cites W2418150095 @default.
• W2141089356 cites W2775779729 @default.
• W2141089356 doi "https://doi.org/10.1080/713608013" @default.
• W2141089356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14636041" @default.
• W2141089356 hasPublicationYear "2003" @default.
• W2141089356 type Work @default.
• W2141089356 sameAs 2141089356 @default.
• W2141089356 citedByCount "14" @default.
• W2141089356 countsByYear W21410893562013 @default.
• W2141089356 countsByYear W21410893562014 @default.
• W2141089356 crossrefType "journal-article" @default.
• W2141089356 hasAuthorship W2141089356A5013773246 @default.
• W2141089356 hasAuthorship W2141089356A5017029216 @default.
• W2141089356 hasAuthorship W2141089356A5022559832 @default.
• W2141089356 hasAuthorship W2141089356A5051394027 @default.
• W2141089356 hasConcept C142724271 @default.

• next