FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141122242> ?p ?o ?g. }

• W2141122242 abstract "Iloprost is a potent prostacyclin analog, which has been shown to exert beneficial effects in several vascular disorders. Inhalation of aerosolized iloprost was found to cause selective pulmonary vasodilatation, and this approach is under current investigation for treatment of chronic pulmonary hypertension. The present study investigated pharmacokinetics and metabolism of aerosolized iloprost in isolated buffer-perfused rabbit lungs, compared with intravascular administration of the prostanoid. After buffer admixture of iloprost, a steady decline of perfusate concentrations of the intact prostanoid was noted (half-life approximately 3.5 h), mostly attributable to progressive metabolism to dinor- and tetranoriloprost. Inhaled iloprost rapidly entered the intravascular compartment, with peak buffer concentrations being noted after 30 min (bioavailability approximately 63%). Compared with infused iloprost, significantly more rapid metabolism to dinor- and tetranoriloprost was noted for iloprost administered via the inhalative route of application. However, the percentage of the nebulized agent that enters the intravascular space as intact iloprost displays the same clearance rate as directly perfusate-admixed prostanoid. We conclude that a high percentage of inhaled iloprost rapidly enters the intravascular compartment in intact rabbit lungs. The lung is capable of metabolizing iloprost via beta-oxidation, and more rapid appearance of dinor- and tetranoriloprost is noted for the inhalative as compared with the intravascular route of iloprost administration." @default.
• W2141122242 created "2016-06-24" @default.
• W2141122242 creator A5016511599 @default.
• W2141122242 creator A5025217725 @default.
• W2141122242 creator A5042716889 @default.
• W2141122242 creator A5042789080 @default.
• W2141122242 creator A5043857150 @default.
• W2141122242 creator A5057281562 @default.
• W2141122242 creator A5057524424 @default.
• W2141122242 creator A5072954654 @default.
• W2141122242 creator A5075523892 @default.
• W2141122242 creator A5083839456 @default.
• W2141122242 creator A5084935661 @default.
• W2141122242 creator A5090575691 @default.
• W2141122242 date "2002-11-01" @default.
• W2141122242 modified "2023-09-27" @default.
• W2141122242 title "Pharmacokinetics and Metabolism of Infused versus Inhaled Iloprost in Isolated Rabbit Lungs" @default.
• W2141122242 cites W1484918835 @default.
• W2141122242 cites W1519428363 @default.
• W2141122242 cites W1839628631 @default.
• W2141122242 cites W1874349195 @default.
• W2141122242 cites W1932677443 @default.
• W2141122242 cites W1966988071 @default.
• W2141122242 cites W1978540294 @default.
• W2141122242 cites W1985648680 @default.
• W2141122242 cites W1990345361 @default.
• W2141122242 cites W2014357539 @default.
• W2141122242 cites W2032676252 @default.
• W2141122242 cites W2057133437 @default.
• W2141122242 cites W2065556350 @default.
• W2141122242 cites W2090213540 @default.
• W2141122242 cites W2090453324 @default.
• W2141122242 cites W2091090974 @default.
• W2141122242 cites W2126076519 @default.
• W2141122242 cites W2129262313 @default.
• W2141122242 cites W2150722914 @default.
• W2141122242 cites W2158223392 @default.
• W2141122242 doi "https://doi.org/10.1124/jpet.303.2.741" @default.
• W2141122242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12388660" @default.
• W2141122242 hasPublicationYear "2002" @default.
• W2141122242 type Work @default.
• W2141122242 sameAs 2141122242 @default.
• W2141122242 citedByCount "26" @default.
• W2141122242 countsByYear W21411222422012 @default.
• W2141122242 countsByYear W21411222422013 @default.
• W2141122242 countsByYear W21411222422014 @default.
• W2141122242 countsByYear W21411222422018 @default.
• W2141122242 crossrefType "journal-article" @default.
• W2141122242 hasAuthorship W2141122242A5016511599 @default.
• W2141122242 hasAuthorship W2141122242A5025217725 @default.
• W2141122242 hasAuthorship W2141122242A5042716889 @default.
• W2141122242 hasAuthorship W2141122242A5042789080 @default.
• W2141122242 hasAuthorship W2141122242A5043857150 @default.
• W2141122242 hasAuthorship W2141122242A5057281562 @default.
• W2141122242 hasAuthorship W2141122242A5057524424 @default.
• W2141122242 hasAuthorship W2141122242A5072954654 @default.
• W2141122242 hasAuthorship W2141122242A5075523892 @default.
• W2141122242 hasAuthorship W2141122242A5083839456 @default.
• W2141122242 hasAuthorship W2141122242A5084935661 @default.
• W2141122242 hasAuthorship W2141122242A5090575691 @default.
• W2141122242 hasConcept C112705442 @default.
• W2141122242 hasConcept C120770815 @default.
• W2141122242 hasConcept C126322002 @default.
• W2141122242 hasConcept C185592680 @default.
• W2141122242 hasConcept C2776954882 @default.
• W2141122242 hasConcept C2777714996 @default.
• W2141122242 hasConcept C2778266237 @default.
• W2141122242 hasConcept C2780664492 @default.
• W2141122242 hasConcept C2781103887 @default.
• W2141122242 hasConcept C2781128415 @default.
• W2141122242 hasConcept C42219234 @default.
• W2141122242 hasConcept C71924100 @default.
• W2141122242 hasConcept C98274493 @default.
• W2141122242 hasConceptScore W2141122242C112705442 @default.
• W2141122242 hasConceptScore W2141122242C120770815 @default.
• W2141122242 hasConceptScore W2141122242C126322002 @default.
• W2141122242 hasConceptScore W2141122242C185592680 @default.
• W2141122242 hasConceptScore W2141122242C2776954882 @default.
• W2141122242 hasConceptScore W2141122242C2777714996 @default.
• W2141122242 hasConceptScore W2141122242C2778266237 @default.
• W2141122242 hasConceptScore W2141122242C2780664492 @default.
• W2141122242 hasConceptScore W2141122242C2781103887 @default.
• W2141122242 hasConceptScore W2141122242C2781128415 @default.
• W2141122242 hasConceptScore W2141122242C42219234 @default.
• W2141122242 hasConceptScore W2141122242C71924100 @default.
• W2141122242 hasConceptScore W2141122242C98274493 @default.
• W2141122242 hasLocation W21411222421 @default.
• W2141122242 hasLocation W21411222422 @default.
• W2141122242 hasOpenAccess W2141122242 @default.
• W2141122242 hasPrimaryLocation W21411222421 @default.
• W2141122242 hasRelatedWork W1975163309 @default.
• W2141122242 hasRelatedWork W1985648680 @default.
• W2141122242 hasRelatedWork W1990345361 @default.
• W2141122242 hasRelatedWork W2023103539 @default.
• W2141122242 hasRelatedWork W2032676252 @default.
• W2141122242 hasRelatedWork W2052748149 @default.
• W2141122242 hasRelatedWork W2090213540 @default.
• W2141122242 hasRelatedWork W2091090974 @default.
• W2141122242 hasRelatedWork W2092310248 @default.
• W2141122242 hasRelatedWork W2102822995 @default.

• next