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• W2141124631 endingPage "2447" @default.
• W2141124631 startingPage "2434" @default.
• W2141124631 abstract "ABSTRACT Vibrio cholerae is the causative agent of the acute diarrheal disease of cholera. Innate immune responses to V. cholerae are not a major cause of cholera pathology, which is characterized by severe, watery diarrhea induced by the action of cholera toxin. Innate responses may, however, contribute to resolution of infection and must be required to initiate adaptive responses after natural infection and oral vaccination. Here we investigated whether a well-established infant mouse model of cholera can be used to observe an innate immune response. We also used a vaccination model in which immunized dams protect their pups from infection through breast milk antibodies to investigate innate immune responses after V. cholerae infection for pups suckled by an immune dam. At the peak of infection, we observed neutrophil recruitment accompanied by induction of KC, macrophage inflammatory protein 2 (MIP-2), NOS-2, interleukin-6 (IL-6), and IL-17a. Pups suckled by an immunized dam did not mount this response. Accessory toxins RtxA and HlyA played no discernible role in neutrophil recruitment in a wild-type background. The innate response to V. cholerae deleted for cholera toxin-encoding phage (CTXϕ) and part of rtxA was significantly reduced, suggesting a role for CTXϕ-carried genes or for RtxA in the absence of cholera toxin (CTX). Two extracellular V. cholerae DNases were not required for neutrophil recruitment, but DNase-deficient V. cholerae caused more clouds of DNA in the intestinal lumen, which appeared to be neutrophil extracellular traps (NETs), suggesting that V. cholerae DNases combat NETs. Thus, the infant mouse model has hitherto unrecognized utility for interrogating innate responses to V. cholerae infection." @default.
• W2141124631 created "2016-06-24" @default.
• W2141124631 creator A5009524336 @default.
• W2141124631 creator A5035252403 @default.
• W2141124631 creator A5082263405 @default.
• W2141124631 date "2014-06-01" @default.
• W2141124631 modified "2023-09-26" @default.
• W2141124631 title "Vibrio cholerae-Induced Inflammation in the Neonatal Mouse Cholera Model" @default.
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• W2141124631 doi "https://doi.org/10.1128/iai.00054-14" @default.
• W2141124631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4019157" @default.
• W2141124631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24686062" @default.
• W2141124631 hasPublicationYear "2014" @default.
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