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• W2141142106 abstract "COMATOSE (CTS), the Arabidopsis homologue of human Adrenoleukodystrophy protein (ALDP), is required for import of substrates for peroxisomal β-oxidation. A new allelic series and a homology model based on the bacterial ABC transporter, Sav1866, provide novel insights into structure-function relations of ABC subfamily D proteins. In contrast to ALDP, where the majority of mutations result in protein absence from the peroxisomal membrane, all CTS mutants produced stable protein. Mutation of conserved residues in the Walker A and B motifs in CTS nucleotide-binding domain (NBD) 1 resulted in a null phenotype but had little effect in NBD2, indicating that the NBDs are functionally distinct in vivo. Two alleles containing mutations in NBD1 outside the Walker motifs (E617K and C631Y) exhibited resistance to auxin precursors 2,4-dichlorophenoxybutyric acid (2,4-DB) and indole butyric acid (IBA) but were wild type in all other tests. The homology model predicted that the transmission interfaces are domain-swapped in CTS, and the differential effects of mutations in the conserved “EAA motif” of coupling helix 2 supported this prediction, consistent with distinct roles for each NBD. Our findings demonstrate that CTS functions can be separated by mutagenesis and the structural model provides a framework for interpretation of phenotypic data." @default.
• W2141142106 created "2016-06-24" @default.
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• W2141142106 date "2009-01-01" @default.
• W2141142106 modified "2023-09-27" @default.
• W2141142106 title "Mutations in the<i>Arabidopsis</i>Peroxisomal ABC Transporter COMATOSE Allow Differentiation between Multiple Functions In Planta: Insights from an Allelic Series" @default.
• W2141142106 cites W124504601 @default.
• W2141142106 cites W1535422451 @default.
• W2141142106 cites W1565953788 @default.
• W2141142106 cites W1595347157 @default.
• W2141142106 cites W1807250678 @default.
• W2141142106 cites W1848111151 @default.
• W2141142106 cites W1927723646 @default.
• W2141142106 cites W1964828092 @default.
• W2141142106 cites W1969008019 @default.
• W2141142106 cites W1969387586 @default.
• W2141142106 cites W1973876121 @default.
• W2141142106 cites W1974227479 @default.
• W2141142106 cites W1980651502 @default.
• W2141142106 cites W1981893537 @default.
• W2141142106 cites W1982230975 @default.
• W2141142106 cites W1982522242 @default.
• W2141142106 cites W1983764349 @default.
• W2141142106 cites W1985672531 @default.
• W2141142106 cites W1986191025 @default.
• W2141142106 cites W1986297143 @default.
• W2141142106 cites W1987198662 @default.
• W2141142106 cites W1992853235 @default.
• W2141142106 cites W1993686817 @default.
• W2141142106 cites W1994348363 @default.
• W2141142106 cites W1995579048 @default.
• W2141142106 cites W1996779865 @default.
• W2141142106 cites W2000925552 @default.
• W2141142106 cites W2001216837 @default.
• W2141142106 cites W2002843405 @default.
• W2141142106 cites W2004844038 @default.
• W2141142106 cites W2008239057 @default.
• W2141142106 cites W2008330611 @default.
• W2141142106 cites W2018871006 @default.
• W2141142106 cites W2031519432 @default.
• W2141142106 cites W2031640156 @default.
• W2141142106 cites W2036028864 @default.
• W2141142106 cites W2040101167 @default.
• W2141142106 cites W2044270028 @default.
• W2141142106 cites W2048832982 @default.
• W2141142106 cites W2049088693 @default.
• W2141142106 cites W2055737079 @default.
• W2141142106 cites W2055771920 @default.
• W2141142106 cites W2058530636 @default.
• W2141142106 cites W2058689517 @default.
• W2141142106 cites W2060391884 @default.
• W2141142106 cites W2068618116 @default.
• W2141142106 cites W2072135452 @default.
• W2141142106 cites W2072412837 @default.
• W2141142106 cites W2083683366 @default.
• W2141142106 cites W2084235175 @default.
• W2141142106 cites W2088020647 @default.
• W2141142106 cites W2094537302 @default.
• W2141142106 cites W2095987756 @default.
• W2141142106 cites W2099108692 @default.
• W2141142106 cites W2101254476 @default.
• W2141142106 cites W2102695302 @default.
• W2141142106 cites W2106007818 @default.
• W2141142106 cites W2106209421 @default.
• W2141142106 cites W2111340994 @default.
• W2141142106 cites W2112606108 @default.
• W2141142106 cites W2114645183 @default.
• W2141142106 cites W2114886480 @default.
• W2141142106 cites W2116753947 @default.
• W2141142106 cites W2117545594 @default.
• W2141142106 cites W2122276553 @default.
• W2141142106 cites W2122941138 @default.
• W2141142106 cites W2124919568 @default.
• W2141142106 cites W2126102313 @default.
• W2141142106 cites W2128528171 @default.
• W2141142106 cites W2128959840 @default.
• W2141142106 cites W2134676206 @default.
• W2141142106 cites W2135777982 @default.
• W2141142106 cites W2138312139 @default.
• W2141142106 cites W2138878645 @default.
• W2141142106 cites W2144462468 @default.
• W2141142106 cites W2153488363 @default.
• W2141142106 cites W2154200037 @default.
• W2141142106 cites W2161983628 @default.
• W2141142106 cites W2162097287 @default.
• W2141142106 cites W2168077163 @default.
• W2141142106 cites W2169992673 @default.
• W2141142106 cites W4235607015 @default.
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• W2141142106 doi "https://doi.org/10.1091/mbc.e08-07-0745" @default.
• W2141142106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2613106" @default.

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